5W3V

Crystal Structure of macaque APOBEC3H in complex with RNA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000932	cellular_component	P-body
A	0002376	biological_process	immune system process
A	0003723	molecular_function	RNA binding
A	0003824	molecular_function	catalytic activity
A	0004126	molecular_function	cytidine deaminase activity
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0008270	molecular_function	zinc ion binding
A	0016554	biological_process	cytidine to uridine editing
A	0016787	molecular_function	hydrolase activity
A	0045087	biological_process	innate immune response
A	0045869	biological_process	negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
A	0046872	molecular_function	metal ion binding
A	0047844	molecular_function	deoxycytidine deaminase activity
A	0051607	biological_process	defense response to virus
A	0070383	biological_process	DNA cytosine deamination
A	0080111	biological_process	DNA demethylation
B	0000932	cellular_component	P-body
B	0002376	biological_process	immune system process
B	0003723	molecular_function	RNA binding
B	0003824	molecular_function	catalytic activity
B	0004126	molecular_function	cytidine deaminase activity
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0008270	molecular_function	zinc ion binding
B	0016554	biological_process	cytidine to uridine editing
B	0016787	molecular_function	hydrolase activity
B	0045087	biological_process	innate immune response
B	0045869	biological_process	negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
B	0046872	molecular_function	metal ion binding
B	0047844	molecular_function	deoxycytidine deaminase activity
B	0051607	biological_process	defense response to virus
B	0070383	biological_process	DNA cytosine deamination
B	0080111	biological_process	DNA demethylation
C	0000932	cellular_component	P-body
C	0002376	biological_process	immune system process
C	0003723	molecular_function	RNA binding
C	0003824	molecular_function	catalytic activity
C	0004126	molecular_function	cytidine deaminase activity
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0008270	molecular_function	zinc ion binding
C	0016554	biological_process	cytidine to uridine editing
C	0016787	molecular_function	hydrolase activity
C	0045087	biological_process	innate immune response
C	0045869	biological_process	negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
C	0046872	molecular_function	metal ion binding
C	0047844	molecular_function	deoxycytidine deaminase activity
C	0051607	biological_process	defense response to virus
C	0070383	biological_process	DNA cytosine deamination
C	0080111	biological_process	DNA demethylation
D	0000932	cellular_component	P-body
D	0002376	biological_process	immune system process
D	0003723	molecular_function	RNA binding
D	0003824	molecular_function	catalytic activity
D	0004126	molecular_function	cytidine deaminase activity
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0008270	molecular_function	zinc ion binding
D	0016554	biological_process	cytidine to uridine editing
D	0016787	molecular_function	hydrolase activity
D	0045087	biological_process	innate immune response
D	0045869	biological_process	negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
D	0046872	molecular_function	metal ion binding
D	0047844	molecular_function	deoxycytidine deaminase activity
D	0051607	biological_process	defense response to virus
D	0070383	biological_process	DNA cytosine deamination
D	0080111	biological_process	DNA demethylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue ZN A 300

Chain	Residue
A	HIS54
A	GLU56
A	CYS85
A	CYS88
A	HOH442

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site_id	AC2
Number of Residues	4
Details	binding site for residue ZN B 301

Chain	Residue
B	HIS54
B	CYS85
B	CYS88
B	HOH409

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site_id	AC3
Number of Residues	4
Details	binding site for residue ZN C 301

Chain	Residue
C	HIS54
C	CYS85
C	CYS88
C	HOH411

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site_id	AC4
Number of Residues	4
Details	binding site for residue ZN D 301

Chain	Residue
D	HIS54
D	CYS85
D	CYS88
D	HOH437

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Functional Information from PROSITE/UniProt

site_id	PS00903
Number of Residues	39
Details	CYT_DCMP_DEAMINASES_1 Cytidine and deoxycytidylate deaminases zinc-binding region signature. HAEirFIneiksmgldetqcyqvtcyltws..........PCps......CageL

Chain	Residue	Details
B	HIS54-LEU92
A	HIS54-LEU92

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