5W25
Crystal structure of Aspartyl-tRNA synthetase from Mycobacterium tuberculosis complexed with L-Aspartic Acid
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| A | 0004815 | molecular_function | aspartate-tRNA ligase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006412 | biological_process | translation |
| A | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| A | 0006422 | biological_process | aspartyl-tRNA aminoacylation |
| A | 0009274 | cellular_component | peptidoglycan-based cell wall |
| A | 0016874 | molecular_function | ligase activity |
| A | 0050560 | molecular_function | aspartate-tRNA(Asn) ligase activity |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0003676 | molecular_function | nucleic acid binding |
| B | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| B | 0004815 | molecular_function | aspartate-tRNA ligase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006412 | biological_process | translation |
| B | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| B | 0006422 | biological_process | aspartyl-tRNA aminoacylation |
| B | 0009274 | cellular_component | peptidoglycan-based cell wall |
| B | 0016874 | molecular_function | ligase activity |
| B | 0050560 | molecular_function | aspartate-tRNA(Asn) ligase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | binding site for residue ASP A 701 |
| Chain | Residue |
| A | GLU173 |
| A | ARG492 |
| A | ILE534 |
| A | ALA535 |
| A | SER195 |
| A | GLN197 |
| A | LYS200 |
| A | ARG219 |
| A | GLN233 |
| A | HIS451 |
| A | HIS452 |
| A | GLY488 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue LYS A 702 |
| Chain | Residue |
| A | ARG3 |
| B | PHE240 |
| B | VAL241 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue LYS A 703 |
| Chain | Residue |
| A | ASP158 |
| A | ARG210 |
| B | ARG3 |
| B | ALA42 |
| B | GLU703 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue GLU A 704 |
| Chain | Residue |
| A | ALA42 |
| A | SER43 |
| A | ASP134 |
| site_id | AC5 |
| Number of Residues | 12 |
| Details | binding site for residue ASP B 701 |
| Chain | Residue |
| B | GLU173 |
| B | GLN197 |
| B | LYS200 |
| B | ARG219 |
| B | GLN233 |
| B | HIS451 |
| B | HIS452 |
| B | GLY488 |
| B | GLY489 |
| B | ARG492 |
| B | ILE534 |
| B | ALA535 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue LYS B 702 |
| Chain | Residue |
| A | PHE240 |
| B | ARG3 |
| B | ALA6 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue GLU B 703 |
| Chain | Residue |
| A | LYS703 |
| B | SER43 |
| B | ASP134 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 14 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00044 |
| Chain | Residue | Details |
| A | GLU173 | |
| B | GLN228 | |
| B | HIS451 | |
| B | GLU485 | |
| B | ARG492 | |
| B | GLY537 | |
| A | ARG219 | |
| A | GLN228 | |
| A | HIS451 | |
| A | GLU485 | |
| A | ARG492 | |
| A | GLY537 | |
| B | GLU173 | |
| B | ARG219 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | SITE: Important for tRNA non-discrimination => ECO:0000255|HAMAP-Rule:MF_00044 |
| Chain | Residue | Details |
| A | HIS31 | |
| A | GLY83 | |
| B | HIS31 | |
| B | GLY83 |
