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5W1S

X-ray crystal structure of Escherichia coli RNA polymerase and TraR complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000345cellular_componentcytosolic DNA-directed RNA polymerase complex
A0000428cellular_componentDNA-directed RNA polymerase complex
A0001054molecular_functionRNA polymerase I activity
A0001055molecular_functionRNA polymerase II activity
A0001056molecular_functionRNA polymerase III activity
A0001057molecular_functionRNA polymerase IV activity
A0001058molecular_functionRNA polymerase V activity
A0001059biological_processtranscription by RNA polymerase IV
A0001060biological_processtranscription by RNA polymerase V
A0001066molecular_functionplastid single subunit type RNA polymerase activity
A0003677molecular_functionDNA binding
A0003899molecular_functionDNA-directed 5'-3' RNA polymerase activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006351biological_processDNA-templated transcription
A0006352biological_processDNA-templated transcription initiation
A0006360biological_processtranscription by RNA polymerase I
A0006366biological_processtranscription by RNA polymerase II
A0006383biological_processtranscription by RNA polymerase III
A0006879biological_processintracellular iron ion homeostasis
A0008023cellular_componenttranscription elongation factor complex
A0009408biological_processresponse to heat
A0016020cellular_componentmembrane
A0016779molecular_functionnucleotidyltransferase activity
A0031564biological_processtranscription antitermination
A0032784biological_processregulation of DNA-templated transcription elongation
A0034062molecular_function5'-3' RNA polymerase activity
A0036460biological_processcellular response to cell envelope stress
A0042128biological_processnitrate assimilation
A0042793biological_processplastid transcription
A0044780biological_processbacterial-type flagellum assembly
A0046983molecular_functionprotein dimerization activity
A0048870biological_processcell motility
A0071973biological_processbacterial-type flagellum-dependent cell motility
A0090605biological_processsubmerged biofilm formation
A2000142biological_processregulation of DNA-templated transcription initiation
B0000345cellular_componentcytosolic DNA-directed RNA polymerase complex
B0000428cellular_componentDNA-directed RNA polymerase complex
B0001054molecular_functionRNA polymerase I activity
B0001055molecular_functionRNA polymerase II activity
B0001056molecular_functionRNA polymerase III activity
B0001057molecular_functionRNA polymerase IV activity
B0001058molecular_functionRNA polymerase V activity
B0001059biological_processtranscription by RNA polymerase IV
B0001060biological_processtranscription by RNA polymerase V
B0001066molecular_functionplastid single subunit type RNA polymerase activity
B0003677molecular_functionDNA binding
B0003899molecular_functionDNA-directed 5'-3' RNA polymerase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006351biological_processDNA-templated transcription
B0006352biological_processDNA-templated transcription initiation
B0006360biological_processtranscription by RNA polymerase I
B0006366biological_processtranscription by RNA polymerase II
B0006383biological_processtranscription by RNA polymerase III
B0006879biological_processintracellular iron ion homeostasis
B0008023cellular_componenttranscription elongation factor complex
B0009408biological_processresponse to heat
B0016020cellular_componentmembrane
B0016779molecular_functionnucleotidyltransferase activity
B0031564biological_processtranscription antitermination
B0032784biological_processregulation of DNA-templated transcription elongation
B0034062molecular_function5'-3' RNA polymerase activity
B0036460biological_processcellular response to cell envelope stress
B0042128biological_processnitrate assimilation
B0042793biological_processplastid transcription
B0044780biological_processbacterial-type flagellum assembly
B0046983molecular_functionprotein dimerization activity
B0048870biological_processcell motility
B0071973biological_processbacterial-type flagellum-dependent cell motility
B0090605biological_processsubmerged biofilm formation
B2000142biological_processregulation of DNA-templated transcription initiation
C0000345cellular_componentcytosolic DNA-directed RNA polymerase complex
C0000428cellular_componentDNA-directed RNA polymerase complex
C0001054molecular_functionRNA polymerase I activity
C0001055molecular_functionRNA polymerase II activity
C0001056molecular_functionRNA polymerase III activity
C0001057molecular_functionRNA polymerase IV activity
C0001058molecular_functionRNA polymerase V activity
C0001059biological_processtranscription by RNA polymerase IV
C0001060biological_processtranscription by RNA polymerase V
C0001066molecular_functionplastid single subunit type RNA polymerase activity
C0003677molecular_functionDNA binding
C0003899molecular_functionDNA-directed 5'-3' RNA polymerase activity
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006351biological_processDNA-templated transcription
C0006352biological_processDNA-templated transcription initiation
C0006360biological_processtranscription by RNA polymerase I
C0006366biological_processtranscription by RNA polymerase II
C0006383biological_processtranscription by RNA polymerase III
C0006879biological_processintracellular iron ion homeostasis
C0008023cellular_componenttranscription elongation factor complex
C0009408biological_processresponse to heat
C0016020cellular_componentmembrane
C0016779molecular_functionnucleotidyltransferase activity
C0031564biological_processtranscription antitermination
C0032549molecular_functionribonucleoside binding
C0032784biological_processregulation of DNA-templated transcription elongation
C0034062molecular_function5'-3' RNA polymerase activity
C0036460biological_processcellular response to cell envelope stress
C0042128biological_processnitrate assimilation
C0042793biological_processplastid transcription
C0044780biological_processbacterial-type flagellum assembly
C0046677biological_processresponse to antibiotic
C0048870biological_processcell motility
C0071973biological_processbacterial-type flagellum-dependent cell motility
C0090605biological_processsubmerged biofilm formation
C2000142biological_processregulation of DNA-templated transcription initiation
D0000287molecular_functionmagnesium ion binding
D0000345cellular_componentcytosolic DNA-directed RNA polymerase complex
D0000428cellular_componentDNA-directed RNA polymerase complex
D0001054molecular_functionRNA polymerase I activity
D0001055molecular_functionRNA polymerase II activity
D0001056molecular_functionRNA polymerase III activity
D0001057molecular_functionRNA polymerase IV activity
D0001058molecular_functionRNA polymerase V activity
D0001059biological_processtranscription by RNA polymerase IV
D0001060biological_processtranscription by RNA polymerase V
D0001066molecular_functionplastid single subunit type RNA polymerase activity
D0003677molecular_functionDNA binding
D0003899molecular_functionDNA-directed 5'-3' RNA polymerase activity
D0005515molecular_functionprotein binding
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006351biological_processDNA-templated transcription
D0006352biological_processDNA-templated transcription initiation
D0006360biological_processtranscription by RNA polymerase I
D0006366biological_processtranscription by RNA polymerase II
D0006383biological_processtranscription by RNA polymerase III
D0006879biological_processintracellular iron ion homeostasis
D0008023cellular_componenttranscription elongation factor complex
D0008270molecular_functionzinc ion binding
D0009408biological_processresponse to heat
D0016020cellular_componentmembrane
D0016779molecular_functionnucleotidyltransferase activity
D0031564biological_processtranscription antitermination
D0032784biological_processregulation of DNA-templated transcription elongation
D0034062molecular_function5'-3' RNA polymerase activity
D0036460biological_processcellular response to cell envelope stress
D0042128biological_processnitrate assimilation
D0042793biological_processplastid transcription
D0044780biological_processbacterial-type flagellum assembly
D0046677biological_processresponse to antibiotic
D0046872molecular_functionmetal ion binding
D0048870biological_processcell motility
D0071973biological_processbacterial-type flagellum-dependent cell motility
D0090605biological_processsubmerged biofilm formation
D2000142biological_processregulation of DNA-templated transcription initiation
E0000345cellular_componentcytosolic DNA-directed RNA polymerase complex
E0000428cellular_componentDNA-directed RNA polymerase complex
E0001000molecular_functionbacterial-type RNA polymerase core enzyme binding
E0001054molecular_functionRNA polymerase I activity
E0001055molecular_functionRNA polymerase II activity
E0001056molecular_functionRNA polymerase III activity
E0001057molecular_functionRNA polymerase IV activity
E0001058molecular_functionRNA polymerase V activity
E0001059biological_processtranscription by RNA polymerase IV
E0001060biological_processtranscription by RNA polymerase V
E0001066molecular_functionplastid single subunit type RNA polymerase activity
E0003677molecular_functionDNA binding
E0003899molecular_functionDNA-directed 5'-3' RNA polymerase activity
E0005829cellular_componentcytosol
E0006351biological_processDNA-templated transcription
E0006352biological_processDNA-templated transcription initiation
E0006360biological_processtranscription by RNA polymerase I
E0006366biological_processtranscription by RNA polymerase II
E0006383biological_processtranscription by RNA polymerase III
E0006879biological_processintracellular iron ion homeostasis
E0008023cellular_componenttranscription elongation factor complex
E0009408biological_processresponse to heat
E0016779molecular_functionnucleotidyltransferase activity
E0030880cellular_componentRNA polymerase complex
E0031564biological_processtranscription antitermination
E0032784biological_processregulation of DNA-templated transcription elongation
E0034062molecular_function5'-3' RNA polymerase activity
E0036460biological_processcellular response to cell envelope stress
E0042128biological_processnitrate assimilation
E0042793biological_processplastid transcription
E0044780biological_processbacterial-type flagellum assembly
E0048870biological_processcell motility
E0065003biological_processprotein-containing complex assembly
E0071973biological_processbacterial-type flagellum-dependent cell motility
E0090605biological_processsubmerged biofilm formation
E2000142biological_processregulation of DNA-templated transcription initiation
F0000345cellular_componentcytosolic DNA-directed RNA polymerase complex
F0003677molecular_functionDNA binding
F0003700molecular_functionDNA-binding transcription factor activity
F0005515molecular_functionprotein binding
F0005737cellular_componentcytoplasm
F0005829cellular_componentcytosol
F0006351biological_processDNA-templated transcription
F0006352biological_processDNA-templated transcription initiation
F0006355biological_processregulation of DNA-templated transcription
F0009408biological_processresponse to heat
F0010468biological_processregulation of gene expression
F0016987molecular_functionsigma factor activity
F0045892biological_processnegative regulation of DNA-templated transcription
F1903865cellular_componentsigma factor antagonist complex
F2000142biological_processregulation of DNA-templated transcription initiation
G0000345cellular_componentcytosolic DNA-directed RNA polymerase complex
G0000428cellular_componentDNA-directed RNA polymerase complex
G0001054molecular_functionRNA polymerase I activity
G0001055molecular_functionRNA polymerase II activity
G0001056molecular_functionRNA polymerase III activity
G0001057molecular_functionRNA polymerase IV activity
G0001058molecular_functionRNA polymerase V activity
G0001059biological_processtranscription by RNA polymerase IV
G0001060biological_processtranscription by RNA polymerase V
G0001066molecular_functionplastid single subunit type RNA polymerase activity
G0003677molecular_functionDNA binding
G0003899molecular_functionDNA-directed 5'-3' RNA polymerase activity
G0005515molecular_functionprotein binding
G0005737cellular_componentcytoplasm
G0005829cellular_componentcytosol
G0006351biological_processDNA-templated transcription
G0006352biological_processDNA-templated transcription initiation
G0006360biological_processtranscription by RNA polymerase I
G0006366biological_processtranscription by RNA polymerase II
G0006383biological_processtranscription by RNA polymerase III
G0006879biological_processintracellular iron ion homeostasis
G0008023cellular_componenttranscription elongation factor complex
G0009408biological_processresponse to heat
G0016020cellular_componentmembrane
G0016779molecular_functionnucleotidyltransferase activity
G0031564biological_processtranscription antitermination
G0032784biological_processregulation of DNA-templated transcription elongation
G0034062molecular_function5'-3' RNA polymerase activity
G0036460biological_processcellular response to cell envelope stress
G0042128biological_processnitrate assimilation
G0042793biological_processplastid transcription
G0044780biological_processbacterial-type flagellum assembly
G0046983molecular_functionprotein dimerization activity
G0048870biological_processcell motility
G0071973biological_processbacterial-type flagellum-dependent cell motility
G0090605biological_processsubmerged biofilm formation
G2000142biological_processregulation of DNA-templated transcription initiation
H0000345cellular_componentcytosolic DNA-directed RNA polymerase complex
H0000428cellular_componentDNA-directed RNA polymerase complex
H0001054molecular_functionRNA polymerase I activity
H0001055molecular_functionRNA polymerase II activity
H0001056molecular_functionRNA polymerase III activity
H0001057molecular_functionRNA polymerase IV activity
H0001058molecular_functionRNA polymerase V activity
H0001059biological_processtranscription by RNA polymerase IV
H0001060biological_processtranscription by RNA polymerase V
H0001066molecular_functionplastid single subunit type RNA polymerase activity
H0003677molecular_functionDNA binding
H0003899molecular_functionDNA-directed 5'-3' RNA polymerase activity
H0005515molecular_functionprotein binding
H0005737cellular_componentcytoplasm
H0005829cellular_componentcytosol
H0006351biological_processDNA-templated transcription
H0006352biological_processDNA-templated transcription initiation
H0006360biological_processtranscription by RNA polymerase I
H0006366biological_processtranscription by RNA polymerase II
H0006383biological_processtranscription by RNA polymerase III
H0006879biological_processintracellular iron ion homeostasis
H0008023cellular_componenttranscription elongation factor complex
H0009408biological_processresponse to heat
H0016020cellular_componentmembrane
H0016779molecular_functionnucleotidyltransferase activity
H0031564biological_processtranscription antitermination
H0032784biological_processregulation of DNA-templated transcription elongation
H0034062molecular_function5'-3' RNA polymerase activity
H0036460biological_processcellular response to cell envelope stress
H0042128biological_processnitrate assimilation
H0042793biological_processplastid transcription
H0044780biological_processbacterial-type flagellum assembly
H0046983molecular_functionprotein dimerization activity
H0048870biological_processcell motility
H0071973biological_processbacterial-type flagellum-dependent cell motility
H0090605biological_processsubmerged biofilm formation
H2000142biological_processregulation of DNA-templated transcription initiation
I0000345cellular_componentcytosolic DNA-directed RNA polymerase complex
I0000428cellular_componentDNA-directed RNA polymerase complex
I0001054molecular_functionRNA polymerase I activity
I0001055molecular_functionRNA polymerase II activity
I0001056molecular_functionRNA polymerase III activity
I0001057molecular_functionRNA polymerase IV activity
I0001058molecular_functionRNA polymerase V activity
I0001059biological_processtranscription by RNA polymerase IV
I0001060biological_processtranscription by RNA polymerase V
I0001066molecular_functionplastid single subunit type RNA polymerase activity
I0003677molecular_functionDNA binding
I0003899molecular_functionDNA-directed 5'-3' RNA polymerase activity
I0005515molecular_functionprotein binding
I0005737cellular_componentcytoplasm
I0005829cellular_componentcytosol
I0006351biological_processDNA-templated transcription
I0006352biological_processDNA-templated transcription initiation
I0006360biological_processtranscription by RNA polymerase I
I0006366biological_processtranscription by RNA polymerase II
I0006383biological_processtranscription by RNA polymerase III
I0006879biological_processintracellular iron ion homeostasis
I0008023cellular_componenttranscription elongation factor complex
I0009408biological_processresponse to heat
I0016020cellular_componentmembrane
I0016779molecular_functionnucleotidyltransferase activity
I0031564biological_processtranscription antitermination
I0032549molecular_functionribonucleoside binding
I0032784biological_processregulation of DNA-templated transcription elongation
I0034062molecular_function5'-3' RNA polymerase activity
I0036460biological_processcellular response to cell envelope stress
I0042128biological_processnitrate assimilation
I0042793biological_processplastid transcription
I0044780biological_processbacterial-type flagellum assembly
I0046677biological_processresponse to antibiotic
I0048870biological_processcell motility
I0071973biological_processbacterial-type flagellum-dependent cell motility
I0090605biological_processsubmerged biofilm formation
I2000142biological_processregulation of DNA-templated transcription initiation
J0000287molecular_functionmagnesium ion binding
J0000345cellular_componentcytosolic DNA-directed RNA polymerase complex
J0000428cellular_componentDNA-directed RNA polymerase complex
J0001054molecular_functionRNA polymerase I activity
J0001055molecular_functionRNA polymerase II activity
J0001056molecular_functionRNA polymerase III activity
J0001057molecular_functionRNA polymerase IV activity
J0001058molecular_functionRNA polymerase V activity
J0001059biological_processtranscription by RNA polymerase IV
J0001060biological_processtranscription by RNA polymerase V
J0001066molecular_functionplastid single subunit type RNA polymerase activity
J0003677molecular_functionDNA binding
J0003899molecular_functionDNA-directed 5'-3' RNA polymerase activity
J0005515molecular_functionprotein binding
J0005737cellular_componentcytoplasm
J0005829cellular_componentcytosol
J0006351biological_processDNA-templated transcription
J0006352biological_processDNA-templated transcription initiation
J0006360biological_processtranscription by RNA polymerase I
J0006366biological_processtranscription by RNA polymerase II
J0006383biological_processtranscription by RNA polymerase III
J0006879biological_processintracellular iron ion homeostasis
J0008023cellular_componenttranscription elongation factor complex
J0008270molecular_functionzinc ion binding
J0009408biological_processresponse to heat
J0016020cellular_componentmembrane
J0016779molecular_functionnucleotidyltransferase activity
J0031564biological_processtranscription antitermination
J0032784biological_processregulation of DNA-templated transcription elongation
J0034062molecular_function5'-3' RNA polymerase activity
J0036460biological_processcellular response to cell envelope stress
J0042128biological_processnitrate assimilation
J0042793biological_processplastid transcription
J0044780biological_processbacterial-type flagellum assembly
J0046677biological_processresponse to antibiotic
J0046872molecular_functionmetal ion binding
J0048870biological_processcell motility
J0071973biological_processbacterial-type flagellum-dependent cell motility
J0090605biological_processsubmerged biofilm formation
J2000142biological_processregulation of DNA-templated transcription initiation
K0000345cellular_componentcytosolic DNA-directed RNA polymerase complex
K0000428cellular_componentDNA-directed RNA polymerase complex
K0001000molecular_functionbacterial-type RNA polymerase core enzyme binding
K0001054molecular_functionRNA polymerase I activity
K0001055molecular_functionRNA polymerase II activity
K0001056molecular_functionRNA polymerase III activity
K0001057molecular_functionRNA polymerase IV activity
K0001058molecular_functionRNA polymerase V activity
K0001059biological_processtranscription by RNA polymerase IV
K0001060biological_processtranscription by RNA polymerase V
K0001066molecular_functionplastid single subunit type RNA polymerase activity
K0003677molecular_functionDNA binding
K0003899molecular_functionDNA-directed 5'-3' RNA polymerase activity
K0005829cellular_componentcytosol
K0006351biological_processDNA-templated transcription
K0006352biological_processDNA-templated transcription initiation
K0006360biological_processtranscription by RNA polymerase I
K0006366biological_processtranscription by RNA polymerase II
K0006383biological_processtranscription by RNA polymerase III
K0006879biological_processintracellular iron ion homeostasis
K0008023cellular_componenttranscription elongation factor complex
K0009408biological_processresponse to heat
K0016779molecular_functionnucleotidyltransferase activity
K0030880cellular_componentRNA polymerase complex
K0031564biological_processtranscription antitermination
K0032784biological_processregulation of DNA-templated transcription elongation
K0034062molecular_function5'-3' RNA polymerase activity
K0036460biological_processcellular response to cell envelope stress
K0042128biological_processnitrate assimilation
K0042793biological_processplastid transcription
K0044780biological_processbacterial-type flagellum assembly
K0048870biological_processcell motility
K0065003biological_processprotein-containing complex assembly
K0071973biological_processbacterial-type flagellum-dependent cell motility
K0090605biological_processsubmerged biofilm formation
K2000142biological_processregulation of DNA-templated transcription initiation
L0000345cellular_componentcytosolic DNA-directed RNA polymerase complex
L0003677molecular_functionDNA binding
L0003700molecular_functionDNA-binding transcription factor activity
L0005515molecular_functionprotein binding
L0005737cellular_componentcytoplasm
L0005829cellular_componentcytosol
L0006351biological_processDNA-templated transcription
L0006352biological_processDNA-templated transcription initiation
L0006355biological_processregulation of DNA-templated transcription
L0009408biological_processresponse to heat
L0010468biological_processregulation of gene expression
L0016987molecular_functionsigma factor activity
L0045892biological_processnegative regulation of DNA-templated transcription
L1903865cellular_componentsigma factor antagonist complex
L2000142biological_processregulation of DNA-templated transcription initiation
M0008270molecular_functionzinc ion binding
M0046872molecular_functionmetal ion binding
N0008270molecular_functionzinc ion binding
N0046872molecular_functionmetal ion binding
Functional Information from PDB Data
site_idAC1
Number of Residues4
Detailsbinding site for residue MG D 2001
ChainResidue
DASP460
DASP462
DASP464
MGLU4

site_idAC2
Number of Residues4
Detailsbinding site for residue ZN D 2002
ChainResidue
DCYS70
DCYS72
DCYS85
DCYS88

site_idAC3
Number of Residues4
Detailsbinding site for residue ZN D 2003
ChainResidue
DCYS888
DCYS895
DCYS898
DCYS814

site_idAC4
Number of Residues4
Detailsbinding site for residue MG J 2001
ChainResidue
JASP460
JASP462
JASP464
NGLU4

site_idAC5
Number of Residues4
Detailsbinding site for residue ZN J 2002
ChainResidue
JCYS70
JCYS72
JCYS85
JCYS88

site_idAC6
Number of Residues4
Detailsbinding site for residue ZN J 2003
ChainResidue
JCYS814
JCYS888
JCYS895
JCYS898

site_idAC7
Number of Residues4
Detailsbinding site for residue ZN M 101
ChainResidue
MCYS37
MCYS40
MCYS58
MCYS61

site_idAC8
Number of Residues5
Detailsbinding site for residue ZN N 101
ChainResidue
NCYS37
NALA39
NCYS40
NCYS58
NCYS61

Functional Information from PROSITE/UniProt
site_idPS00715
Number of Residues14
DetailsSIGMA70_1 Sigma-70 factors family signature 1. DLIQeGnIGLMkAV
ChainResidueDetails
FASP403-VAL416

site_idPS00716
Number of Residues27
DetailsSIGMA70_2 Sigma-70 factors family signature 2. TleEVGkqfdVTrerIrQIEakaLrkL
ChainResidueDetails
FTHR572-LEU598

site_idPS01102
Number of Residues25
DetailsZF_DKSA_1 Prokaryotic dksA C4-type zinc finger. CEaCgnpIpeaRrkifPgvtlCveC
ChainResidueDetails
MCYS37-CYS61

site_idPS01166
Number of Residues13
DetailsRNA_POL_BETA RNA polymerases beta chain signature. GdKMAGrHGNKGV
ChainResidueDetails
CGLY1063-VAL1075

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues48
DetailsZN_FING: dksA C4-type => ECO:0000255|PROSITE-ProRule:PRU00510
ChainResidueDetails
MCYS37-CYS61
DCYS895
DCYS898
JCYS70
JCYS72
JCYS85
JCYS88
JASP460
JASP462
JASP464
JCYS814
NCYS37-CYS61
JCYS888
JCYS895
JCYS898
DCYS85
DCYS88
DASP460
DASP462
DASP464
DCYS814
DCYS888

site_idSWS_FT_FI2
Number of Residues2
DetailsSITE: Interaction with anti-sigma factors
ChainResidueDetails
FARG562
LARG562
GLYS297
HLYS297

site_idSWS_FT_FI3
Number of Residues4
DetailsMOD_RES: N6-acetyllysine; by PatZ => ECO:0000269|PubMed:21696463
ChainResidueDetails
ALYS298
BLYS298
GLYS298
HLYS298

227344

PDB entries from 2024-11-13

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