5W1J

Echinococcus granulosus thioredoxin glutathione reductas (egTGR)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004362	molecular_function	glutathione-disulfide reductase (NADPH) activity
A	0004791	molecular_function	thioredoxin-disulfide reductase (NADPH) activity
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0006749	biological_process	glutathione metabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0016668	molecular_function	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
A	0034599	biological_process	cellular response to oxidative stress
A	0045454	biological_process	cell redox homeostasis
A	0050660	molecular_function	flavin adenine dinucleotide binding
A	0098869	biological_process	cellular oxidant detoxification
B	0000166	molecular_function	nucleotide binding
B	0004362	molecular_function	glutathione-disulfide reductase (NADPH) activity
B	0004791	molecular_function	thioredoxin-disulfide reductase (NADPH) activity
B	0005739	cellular_component	mitochondrion
B	0005829	cellular_component	cytosol
B	0006749	biological_process	glutathione metabolic process
B	0016491	molecular_function	oxidoreductase activity
B	0016668	molecular_function	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
B	0034599	biological_process	cellular response to oxidative stress
B	0045454	biological_process	cell redox homeostasis
B	0050660	molecular_function	flavin adenine dinucleotide binding
B	0098869	biological_process	cellular oxidant detoxification

Functional Information from PDB Data

site_id	AC1
Number of Residues	32
Details	binding site for residue FAD A 601

Chain	Residue
A	ILE115
A	THR155
A	CYS156
A	VAL159
A	GLY160
A	CYS161
A	LYS164
A	LEU227
A	GLY228
A	ALA256
A	THR257
A	GLY116
A	GLY258
A	TYR296
A	VAL297
A	ARG393
A	ILE400
A	GLY431
A	ASP432
A	GLN439
A	LEU440
A	THR441
A	GLY117
A	PRO442
B	HIS570
B	PRO571
A	GLY118
A	SER119
A	GLY120
A	ASP139
A	PHE140
A	GLY154

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site_id	AC2
Number of Residues	32
Details	binding site for residue FAD B 601

Chain	Residue
A	HIS570
A	PRO571
B	ILE115
B	GLY116
B	GLY117
B	GLY118
B	SER119
B	GLY120
B	ASP139
B	PHE140
B	GLY154
B	THR155
B	CYS156
B	VAL159
B	GLY160
B	CYS161
B	LYS164
B	ALA226
B	LEU227
B	GLY228
B	ALA256
B	THR257
B	GLY258
B	TYR296
B	ARG393
B	ILE400
B	GLY431
B	ASP432
B	GLN439
B	LEU440
B	THR441
B	PRO442

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Functional Information from PROSITE/UniProt

site_id	PS00076
Number of Residues	11
Details	PYRIDINE_REDOX_1 Pyridine nucleotide-disulphide oxidoreductases class-I active site. GGtCVnvGCIP

Chain	Residue	Details
A	GLY153-PRO163

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