5W0N
Structure of human TUT7 catalytic module (CM) in complex with UMPNPP and U2 RNA
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue MG A 1401 |
| Chain | Residue |
| A | ASP1058 |
| A | ASP1060 |
| A | 2KH1402 |
| A | HOH1512 |
| site_id | AC2 |
| Number of Residues | 26 |
| Details | binding site for residue 2KH A 1402 |
| Chain | Residue |
| A | ASP1058 |
| A | ASP1060 |
| A | ALA1127 |
| A | ASN1130 |
| A | LYS1152 |
| A | SER1170 |
| A | TYR1171 |
| A | HIS1286 |
| A | LEU1288 |
| A | MG1401 |
| A | UPU1403 |
| A | HOH1506 |
| A | HOH1507 |
| A | HOH1511 |
| A | HOH1512 |
| A | HOH1513 |
| A | HOH1520 |
| A | HOH1523 |
| A | HOH1544 |
| A | HOH1555 |
| A | HOH1558 |
| A | PHE1045 |
| A | GLY1046 |
| A | SER1047 |
| A | ASN1050 |
| A | SER1057 |
| site_id | AC3 |
| Number of Residues | 21 |
| Details | binding site for residue UPU A 1403 |
| Chain | Residue |
| A | PHE1045 |
| A | ASP1058 |
| A | ASP1060 |
| A | VAL1104 |
| A | ILE1106 |
| A | ASP1119 |
| A | ASN1124 |
| A | ALA1163 |
| A | SER1164 |
| A | ILE1353 |
| A | GLY1354 |
| A | HIS1355 |
| A | 2KH1402 |
| A | HOH1513 |
| A | HOH1519 |
| A | HOH1529 |
| A | HOH1530 |
| A | HOH1547 |
| A | HOH1549 |
| A | HOH1564 |
| A | HOH1569 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 1404 |
| Chain | Residue |
| A | CYS1347 |
| A | CYS1350 |
| A | HIS1355 |
| A | CYS1360 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | binding site for residue IOD A 1405 |
| Chain | Residue |
| A | SER1293 |
| A | ASP1344 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 1406 |
| Chain | Residue |
| A | ARG1094 |
| B | ARG1094 |
| C | ARG1094 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue MG B 1401 |
| Chain | Residue |
| B | SER1047 |
| B | ASP1058 |
| B | ASP1060 |
| B | 2KH1402 |
| B | HOH1502 |
| site_id | AC8 |
| Number of Residues | 27 |
| Details | binding site for residue 2KH B 1402 |
| Chain | Residue |
| B | PHE1045 |
| B | GLY1046 |
| B | SER1047 |
| B | ASN1050 |
| B | SER1057 |
| B | ASP1058 |
| B | ASP1060 |
| B | ALA1127 |
| B | ASN1130 |
| B | THR1131 |
| B | LYS1152 |
| B | SER1170 |
| B | TYR1171 |
| B | HIS1286 |
| B | LEU1288 |
| B | MG1401 |
| B | UPU1403 |
| B | HOH1505 |
| B | HOH1509 |
| B | HOH1515 |
| B | HOH1518 |
| B | HOH1523 |
| B | HOH1524 |
| B | HOH1525 |
| B | HOH1558 |
| B | HOH1571 |
| B | HOH1573 |
| site_id | AC9 |
| Number of Residues | 25 |
| Details | binding site for residue UPU B 1403 |
| Chain | Residue |
| B | ILE1106 |
| B | ASP1119 |
| B | ASN1124 |
| B | ALA1163 |
| B | SER1164 |
| B | LYS1352 |
| B | ILE1353 |
| B | GLY1354 |
| B | HIS1355 |
| B | 2KH1402 |
| B | HOH1514 |
| B | HOH1516 |
| B | HOH1518 |
| B | HOH1523 |
| B | HOH1527 |
| B | HOH1534 |
| B | HOH1544 |
| B | HOH1547 |
| B | PHE1045 |
| B | ASP1058 |
| B | ASP1060 |
| B | ILE1099 |
| B | THR1101 |
| B | ALA1102 |
| B | VAL1104 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 1404 |
| Chain | Residue |
| B | CYS1347 |
| B | CYS1350 |
| B | HIS1355 |
| B | CYS1360 |
| site_id | AD2 |
| Number of Residues | 1 |
| Details | binding site for residue IOD B 1405 |
| Chain | Residue |
| B | SER1293 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue MG C 1401 |
| Chain | Residue |
| C | SER1047 |
| C | ASP1058 |
| C | ASP1060 |
| C | 2KH1402 |
| C | HOH1504 |
| site_id | AD4 |
| Number of Residues | 25 |
| Details | binding site for residue 2KH C 1402 |
| Chain | Residue |
| C | PHE1045 |
| C | GLY1046 |
| C | SER1047 |
| C | ASN1050 |
| C | SER1057 |
| C | ASP1058 |
| C | ASP1060 |
| C | ASN1130 |
| C | THR1131 |
| C | LYS1152 |
| C | SER1170 |
| C | TYR1171 |
| C | HIS1286 |
| C | LEU1288 |
| C | MG1401 |
| C | UPU1403 |
| C | HOH1501 |
| C | HOH1504 |
| C | HOH1509 |
| C | HOH1511 |
| C | HOH1513 |
| C | HOH1517 |
| C | HOH1518 |
| C | HOH1520 |
| C | HOH1538 |
| site_id | AD5 |
| Number of Residues | 15 |
| Details | binding site for residue UPU C 1403 |
| Chain | Residue |
| C | PHE1045 |
| C | ASP1058 |
| C | ASP1060 |
| C | ILE1099 |
| C | THR1101 |
| C | VAL1104 |
| C | ILE1106 |
| C | ASP1119 |
| C | ASN1124 |
| C | ALA1163 |
| C | SER1164 |
| C | 2KH1402 |
| C | HOH1507 |
| C | HOH1513 |
| C | HOH1530 |
| site_id | AD6 |
| Number of Residues | 2 |
| Details | binding site for residue IOD C 1404 |
| Chain | Residue |
| C | SER1293 |
| C | ASP1344 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 159 |
| Details | Domain: {"description":"PAP-associated 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 34 |
| Details | Zinc finger: {"description":"CCHC-type 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00047","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"28671666","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5W0B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5W0M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5W0N","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 39 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"5W0N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5W0O","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
