5VZI

Post-catalytic complex of human Polymerase Mu (W434H) mutant with incoming dTTP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003887	molecular_function	DNA-directed DNA polymerase activity
A	0005634	cellular_component	nucleus
A	0006281	biological_process	DNA repair
A	0016779	molecular_function	nucleotidyltransferase activity
A	0034061	molecular_function	DNA polymerase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	binding site for residue TTP A 701

Chain	Residue
A	GLY319
A	HOH822
A	HOH859
A	HOH953
P	DT5
P	MG101
P	HOH207
A	GLY320
A	ARG323
A	HIS329
A	ASP330
A	ASP332
A	TTP702
A	MG703
A	HOH810

---

site_id	AC2
Number of Residues	30
Details	binding site for residue TTP A 702

Chain	Residue
A	GLY319
A	GLY320
A	ARG323
A	LYS325
A	GLY328
A	HIS329
A	ASP330
A	ASP332
A	GLY433
A	HIS434
A	THR435
A	GLY436
A	LYS438
A	TTP701
A	MG703
A	MG704
A	NA706
A	HOH810
A	HOH816
A	HOH826
A	HOH859
A	HOH887
A	HOH985
A	HOH1016
P	DA4
P	DT5
P	MG101
P	HOH207
P	HOH209
T	DA5

---

site_id	AC3
Number of Residues	8
Details	binding site for residue MG A 703

Chain	Residue
A	ASP330
A	ASP332
A	TTP701
A	TTP702
A	MG704
A	NA706
A	HOH887
P	DT5

---

site_id	AC4
Number of Residues	9
Details	binding site for residue MG A 704

Chain	Residue
A	ASP330
A	ASP332
A	ASP418
A	TTP702
A	MG703
A	HOH921
P	DA4
P	DT5
P	HOH209

---

site_id	AC5
Number of Residues	7
Details	binding site for residue NA A 705

Chain	Residue
A	THR241
A	ILE243
A	VAL246
A	HOH1001
P	DT3
P	DT5
P	HOH216

---

site_id	AC6
Number of Residues	9
Details	binding site for residue NA A 706

Chain	Residue
A	ASP330
A	ASP332
A	ASP418
A	TTP702
A	MG703
A	HOH921
P	DA4
P	DT5
P	HOH209

---

site_id	AC7
Number of Residues	3
Details	binding site for residue EDO A 707

Chain	Residue
A	PHE462
A	HOH821
T	HOH203

---

site_id	AC8
Number of Residues	6
Details	binding site for residue EDO A 708

Chain	Residue
A	THR288
A	PRO289
A	LEU291
A	GLN396
A	LYS413
A	HOH936

---

site_id	AC9
Number of Residues	5
Details	binding site for residue EDO A 709

Chain	Residue
A	PRO190
A	SER191
A	PRO192
A	GLN198
A	HOH922

---

site_id	AD1
Number of Residues	8
Details	binding site for residue EDO A 710

Chain	Residue
A	HOH932
A	ARG387
A	VAL420
A	VAL421
A	HIS434
A	SER458
A	HIS459
A	HOH815

---

site_id	AD2
Number of Residues	4
Details	binding site for residue MG T 101

Chain	Residue
T	HOH217
T	HOH220
T	HOH224
T	HOH240

---

site_id	AD3
Number of Residues	8
Details	binding site for residue MG P 101

Chain	Residue
A	HIS329
A	TTP701
A	TTP702
A	HOH822
P	DA4
P	DT5
P	HOH207
P	HOH211

---

Functional Information from PROSITE/UniProt

site_id	PS00522
Number of Residues	20
Details	DNA_POLYMERASE_X DNA polymerase family X signature. GGFrRGklqGhDVDFLIthP

Chain	Residue	Details
A	GLY319-PRO338

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	9
Details	Region: {"description":"Involved in ssDNA binding","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Site: {"description":"Responsible for the low discrimination between dNTP and rNTP"}

Chain

Residue

Details

---