5VXS

Crystal Structure Analysis of human CLYBL in apo form

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0003824	molecular_function	catalytic activity
A	0004474	molecular_function	malate synthase activity
A	0005739	cellular_component	mitochondrion
A	0016289	molecular_function	acyl-CoA hydrolase activity
A	0016740	molecular_function	transferase activity
A	0016787	molecular_function	hydrolase activity
A	0016829	molecular_function	lyase activity
A	0046872	molecular_function	metal ion binding
A	0047777	molecular_function	(S)-citramalyl-CoA lyase activity
A	0070207	biological_process	protein homotrimerization
A	0106064	biological_process	regulation of cobalamin metabolic process
A	0106121	biological_process	positive regulation of cobalamin metabolic process
A	0110052	biological_process	toxic metabolite repair
B	0000287	molecular_function	magnesium ion binding
B	0003824	molecular_function	catalytic activity
B	0004474	molecular_function	malate synthase activity
B	0005739	cellular_component	mitochondrion
B	0016289	molecular_function	acyl-CoA hydrolase activity
B	0016740	molecular_function	transferase activity
B	0016787	molecular_function	hydrolase activity
B	0016829	molecular_function	lyase activity
B	0046872	molecular_function	metal ion binding
B	0047777	molecular_function	(S)-citramalyl-CoA lyase activity
B	0070207	biological_process	protein homotrimerization
B	0106064	biological_process	regulation of cobalamin metabolic process
B	0106121	biological_process	positive regulation of cobalamin metabolic process
B	0110052	biological_process	toxic metabolite repair
C	0000287	molecular_function	magnesium ion binding
C	0003824	molecular_function	catalytic activity
C	0004474	molecular_function	malate synthase activity
C	0005739	cellular_component	mitochondrion
C	0016289	molecular_function	acyl-CoA hydrolase activity
C	0016740	molecular_function	transferase activity
C	0016787	molecular_function	hydrolase activity
C	0016829	molecular_function	lyase activity
C	0046872	molecular_function	metal ion binding
C	0047777	molecular_function	(S)-citramalyl-CoA lyase activity
C	0070207	biological_process	protein homotrimerization
C	0106064	biological_process	regulation of cobalamin metabolic process
C	0106121	biological_process	positive regulation of cobalamin metabolic process
C	0110052	biological_process	toxic metabolite repair
D	0000287	molecular_function	magnesium ion binding
D	0003824	molecular_function	catalytic activity
D	0004474	molecular_function	malate synthase activity
D	0005739	cellular_component	mitochondrion
D	0016289	molecular_function	acyl-CoA hydrolase activity
D	0016740	molecular_function	transferase activity
D	0016787	molecular_function	hydrolase activity
D	0016829	molecular_function	lyase activity
D	0046872	molecular_function	metal ion binding
D	0047777	molecular_function	(S)-citramalyl-CoA lyase activity
D	0070207	biological_process	protein homotrimerization
D	0106064	biological_process	regulation of cobalamin metabolic process
D	0106121	biological_process	positive regulation of cobalamin metabolic process
D	0110052	biological_process	toxic metabolite repair
E	0000287	molecular_function	magnesium ion binding
E	0003824	molecular_function	catalytic activity
E	0004474	molecular_function	malate synthase activity
E	0005739	cellular_component	mitochondrion
E	0016289	molecular_function	acyl-CoA hydrolase activity
E	0016740	molecular_function	transferase activity
E	0016787	molecular_function	hydrolase activity
E	0016829	molecular_function	lyase activity
E	0046872	molecular_function	metal ion binding
E	0047777	molecular_function	(S)-citramalyl-CoA lyase activity
E	0070207	biological_process	protein homotrimerization
E	0106064	biological_process	regulation of cobalamin metabolic process
E	0106121	biological_process	positive regulation of cobalamin metabolic process
E	0110052	biological_process	toxic metabolite repair
F	0000287	molecular_function	magnesium ion binding
F	0003824	molecular_function	catalytic activity
F	0004474	molecular_function	malate synthase activity
F	0005739	cellular_component	mitochondrion
F	0016289	molecular_function	acyl-CoA hydrolase activity
F	0016740	molecular_function	transferase activity
F	0016787	molecular_function	hydrolase activity
F	0016829	molecular_function	lyase activity
F	0046872	molecular_function	metal ion binding
F	0047777	molecular_function	(S)-citramalyl-CoA lyase activity
F	0070207	biological_process	protein homotrimerization
F	0106064	biological_process	regulation of cobalamin metabolic process
F	0106121	biological_process	positive regulation of cobalamin metabolic process
F	0110052	biological_process	toxic metabolite repair

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue CIT A 401

Chain	Residue
A	LEU177
A	TYR224
A	LYS228
B	TYR224
B	LYS228
C	TYR224
C	LYS228

---

site_id	AC2
Number of Residues	8
Details	binding site for residue CIT F 401

Chain	Residue
D	LYS228
E	TYR224
E	LYS228
F	LEU177
F	TYR224
F	LYS228
D	LEU177
D	TYR224

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	30
Details	Binding site: {"evidences":[{"source":"PubMed","id":"29056341","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5VXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VXO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"29056341","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5VXC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q8R4N0","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	12
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q8R4N0","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	5
Details	Active site: {"evidences":[{"source":"PubMed","id":"29056341","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q8R4N0","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---