5VXC
Crystal Structure Analysis of human CLYBL in complex with free CoASH
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004474 | molecular_function | malate synthase activity |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0016289 | molecular_function | acyl-CoA hydrolase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016829 | molecular_function | lyase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0047777 | molecular_function | (S)-citramalyl-CoA lyase activity |
| A | 0070207 | biological_process | protein homotrimerization |
| A | 0106064 | biological_process | regulation of cobalamin metabolic process |
| A | 0106121 | biological_process | positive regulation of cobalamin metabolic process |
| A | 0110052 | biological_process | toxic metabolite repair |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | binding site for residue COA A 401 |
| Chain | Residue |
| A | TYR50 |
| A | THR313 |
| A | MET318 |
| A | ASP320 |
| A | HOH507 |
| A | HOH530 |
| A | HOH622 |
| A | LYS57 |
| A | LYS58 |
| A | LYS61 |
| A | ARG107 |
| A | ILE272 |
| A | HIS273 |
| A | PRO274 |
| A | ALA311 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 402 |
| Chain | Residue |
| A | GLU171 |
| A | ASP206 |
| A | HOH510 |
| A | HOH534 |
| A | HOH635 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"evidences":[{"source":"PubMed","id":"29056341","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 5 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"29056341","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5VXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VXO","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"29056341","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5VXC","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q8R4N0","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q8R4N0","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q8R4N0","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
