5VXC
Crystal Structure Analysis of human CLYBL in complex with free CoASH
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004474 | molecular_function | malate synthase activity |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016829 | molecular_function | lyase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0047777 | molecular_function | (S)-citramalyl-CoA lyase activity |
| A | 0070207 | biological_process | protein homotrimerization |
| A | 0106064 | biological_process | regulation of cobalamin metabolic process |
| A | 0106121 | biological_process | positive regulation of cobalamin metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | binding site for residue COA A 401 |
| Chain | Residue |
| A | TYR50 |
| A | THR313 |
| A | MET318 |
| A | ASP320 |
| A | HOH507 |
| A | HOH530 |
| A | HOH622 |
| A | LYS57 |
| A | LYS58 |
| A | LYS61 |
| A | ARG107 |
| A | ILE272 |
| A | HIS273 |
| A | PRO274 |
| A | ALA311 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 402 |
| Chain | Residue |
| A | GLU171 |
| A | ASP206 |
| A | HOH510 |
| A | HOH534 |
| A | HOH635 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: ACT_SITE => ECO:0000269|PubMed:29056341 |
| Chain | Residue | Details |
| A | ASP320 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 5 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:29056341, ECO:0007744|PDB:5VXC, ECO:0007744|PDB:5VXO |
| Chain | Residue | Details |
| A | TYR50 | |
| A | LYS57 | |
| A | LYS61 | |
| A | ARG107 | |
| A | ILE272 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:29056341, ECO:0007744|PDB:5VXC |
| Chain | Residue | Details |
| A | GLU171 | |
| A | ASP206 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q8R4N0 |
| Chain | Residue | Details |
| A | LYS57 | |
| A | LYS61 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q8R4N0 |
| Chain | Residue | Details |
| A | LYS82 | |
| A | LYS92 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q8R4N0 |
| Chain | Residue | Details |
| A | LYS309 |
