5VSM
Crystal structure of viperin with bound [4Fe-4S] cluster, 5'-deoxyadenosine, and L-methionine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0005811 | cellular_component | lipid droplet |
| A | 0051536 | molecular_function | iron-sulfur cluster binding |
| A | 0051607 | biological_process | defense response to virus |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0005789 | cellular_component | endoplasmic reticulum membrane |
| B | 0005811 | cellular_component | lipid droplet |
| B | 0051536 | molecular_function | iron-sulfur cluster binding |
| B | 0051607 | biological_process | defense response to virus |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | binding site for residue SF4 A 401 |
| Chain | Residue |
| A | CYS84 |
| A | CYS88 |
| A | CYS91 |
| A | GLY126 |
| A | ASN158 |
| A | ARG194 |
| A | 5AD402 |
| A | MET403 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | binding site for residue 5AD A 402 |
| Chain | Residue |
| A | PHE92 |
| A | SER180 |
| A | ARG194 |
| A | ASN222 |
| A | VAL224 |
| A | GLN250 |
| A | CYS251 |
| A | LEU252 |
| A | ASN258 |
| A | SF4401 |
| A | MET403 |
| A | HOH580 |
| A | PHE90 |
| site_id | AC3 |
| Number of Residues | 11 |
| Details | binding site for residue MET A 403 |
| Chain | Residue |
| A | SER124 |
| A | GLY125 |
| A | GLY126 |
| A | GLU127 |
| A | VAL156 |
| A | SER157 |
| A | ASN158 |
| A | SER180 |
| A | ARG194 |
| A | SF4401 |
| A | 5AD402 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | binding site for residue SF4 B 401 |
| Chain | Residue |
| B | CYS84 |
| B | CYS88 |
| B | CYS91 |
| B | GLY126 |
| B | ASN158 |
| B | ARG194 |
| B | ARG265 |
| B | 5AD402 |
| B | MET403 |
| site_id | AC5 |
| Number of Residues | 14 |
| Details | binding site for residue 5AD B 402 |
| Chain | Residue |
| B | PHE90 |
| B | PHE92 |
| B | SER180 |
| B | ARG194 |
| B | ASN222 |
| B | VAL224 |
| B | PHE249 |
| B | GLN250 |
| B | CYS251 |
| B | LEU252 |
| B | ASN258 |
| B | SF4401 |
| B | MET403 |
| B | HOH634 |
| site_id | AC6 |
| Number of Residues | 12 |
| Details | binding site for residue MET B 403 |
| Chain | Residue |
| B | PHE92 |
| B | SER124 |
| B | GLY125 |
| B | GLY126 |
| B | GLU127 |
| B | VAL156 |
| B | SER157 |
| B | ASN158 |
| B | SER180 |
| B | ARG194 |
| B | SF4401 |
| B | 5AD402 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"28607080","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5VSL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VSM","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q8WXG1","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"Q8WXG1","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
