5VRE
Crystal structure of a lysosomal potassium-selective channel TMEM175 homolog from Chamaesiphon Minutus
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005267 | molecular_function | potassium channel activity |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006813 | biological_process | potassium ion transport |
| A | 0015252 | molecular_function | proton channel activity |
| A | 0016020 | cellular_component | membrane |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0051289 | biological_process | protein homotetramerization |
| A | 0071805 | biological_process | potassium ion transmembrane transport |
| A | 1902600 | biological_process | proton transmembrane transport |
| B | 0005267 | molecular_function | potassium channel activity |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0006813 | biological_process | potassium ion transport |
| B | 0015252 | molecular_function | proton channel activity |
| B | 0016020 | cellular_component | membrane |
| B | 0034220 | biological_process | monoatomic ion transmembrane transport |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0051289 | biological_process | protein homotetramerization |
| B | 0071805 | biological_process | potassium ion transmembrane transport |
| B | 1902600 | biological_process | proton transmembrane transport |
| C | 0005267 | molecular_function | potassium channel activity |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0006813 | biological_process | potassium ion transport |
| C | 0015252 | molecular_function | proton channel activity |
| C | 0016020 | cellular_component | membrane |
| C | 0034220 | biological_process | monoatomic ion transmembrane transport |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0051289 | biological_process | protein homotetramerization |
| C | 0071805 | biological_process | potassium ion transmembrane transport |
| C | 1902600 | biological_process | proton transmembrane transport |
| D | 0005267 | molecular_function | potassium channel activity |
| D | 0006811 | biological_process | monoatomic ion transport |
| D | 0006813 | biological_process | potassium ion transport |
| D | 0015252 | molecular_function | proton channel activity |
| D | 0016020 | cellular_component | membrane |
| D | 0034220 | biological_process | monoatomic ion transmembrane transport |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0051289 | biological_process | protein homotetramerization |
| D | 0071805 | biological_process | potassium ion transmembrane transport |
| D | 1902600 | biological_process | proton transmembrane transport |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 100 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305|PubMed:28723891 |
| Chain | Residue | Details |
| A | MET1-GLN7 | |
| C | LEU79-ASP84 | |
| C | ALA143-ASP154 | |
| C | ARG200-ALA203 | |
| D | MET1-GLN7 | |
| D | LEU79-ASP84 | |
| D | ALA143-ASP154 | |
| D | ARG200-ALA203 | |
| A | LEU79-ASP84 | |
| A | ALA143-ASP154 | |
| A | ARG200-ALA203 | |
| B | MET1-GLN7 | |
| B | LEU79-ASP84 | |
| B | ALA143-ASP154 | |
| B | ARG200-ALA203 | |
| C | MET1-GLN7 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 92 |
| Details | TRANSMEM: Helical; Name=TM1 => ECO:0000269|PubMed:28723891 |
| Chain | Residue | Details |
| A | SER8-GLU31 | |
| B | SER8-GLU31 | |
| C | SER8-GLU31 | |
| D | SER8-GLU31 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 108 |
| Details | TOPO_DOM: Extracellular => ECO:0000305|PubMed:28723891 |
| Chain | Residue | Details |
| A | ILE32-LEU52 | |
| D | ILE32-LEU52 | |
| D | TYR111-ALA117 | |
| D | SER182-VAL183 | |
| A | TYR111-ALA117 | |
| A | SER182-VAL183 | |
| B | ILE32-LEU52 | |
| B | TYR111-ALA117 | |
| B | SER182-VAL183 | |
| C | ILE32-LEU52 | |
| C | TYR111-ALA117 | |
| C | SER182-VAL183 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 100 |
| Details | TRANSMEM: Helical; Name=TM2 => ECO:0000269|PubMed:28723891 |
| Chain | Residue | Details |
| A | TRP53-SER78 | |
| B | TRP53-SER78 | |
| C | TRP53-SER78 | |
| D | TRP53-SER78 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 100 |
| Details | TRANSMEM: Helical; Name=TM3 => ECO:0000269|PubMed:28723891 |
| Chain | Residue | Details |
| A | HIS85-GLU110 | |
| B | HIS85-GLU110 | |
| C | HIS85-GLU110 | |
| D | HIS85-GLU110 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 96 |
| Details | TRANSMEM: Helical; Name=TM4 => ECO:0000269|PubMed:28723891 |
| Chain | Residue | Details |
| A | ARG118-ALA142 | |
| B | ARG118-ALA142 | |
| C | ARG118-ALA142 | |
| D | ARG118-ALA142 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 104 |
| Details | TRANSMEM: Helical; Name=TM5 => ECO:0000269|PubMed:28723891 |
| Chain | Residue | Details |
| A | ARG155-ILE181 | |
| B | ARG155-ILE181 | |
| C | ARG155-ILE181 | |
| D | ARG155-ILE181 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 60 |
| Details | TRANSMEM: Helical; Name=TM6 => ECO:0000269|PubMed:28723891 |
| Chain | Residue | Details |
| A | TRP184-LEU199 | |
| B | TRP184-LEU199 | |
| C | TRP184-LEU199 | |
| D | TRP184-LEU199 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 4 |
| Details | SITE: Hydrophobic filter residue 1 => ECO:0000269|PubMed:28723891 |
| Chain | Residue | Details |
| A | ILE23 | |
| B | ILE23 | |
| C | ILE23 | |
| D | ILE23 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 4 |
| Details | SITE: Hydrophobic filter residue 2 => ECO:0000269|PubMed:28723891 |
| Chain | Residue | Details |
| A | LEU27 | |
| B | LEU27 | |
| C | LEU27 | |
| D | LEU27 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 4 |
| Details | SITE: Hydrophobic filter residue 3 => ECO:0000269|PubMed:28723891 |
| Chain | Residue | Details |
| A | LEU30 | |
| B | LEU30 | |
| C | LEU30 | |
| D | LEU30 |
