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5VQP

Crystal structure of human pro-TGF-beta1

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0000902biological_processcell morphogenesis
A0001570biological_processvasculogenesis
A0001657biological_processureteric bud development
A0001666biological_processresponse to hypoxia
A0001763biological_processmorphogenesis of a branching structure
A0001775biological_processcell activation
A0001837biological_processepithelial to mesenchymal transition
A0001843biological_processneural tube closure
A0001933biological_processnegative regulation of protein phosphorylation
A0002028biological_processregulation of sodium ion transport
A0002040biological_processsprouting angiogenesis
A0002062biological_processchondrocyte differentiation
A0002069biological_processcolumnar/cuboidal epithelial cell maturation
A0002244biological_processhematopoietic progenitor cell differentiation
A0002248biological_processconnective tissue replacement involved in inflammatory response wound healing
A0002460biological_processadaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
A0002513biological_processtolerance induction to self antigen
A0002859biological_processnegative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
A0003179biological_processheart valve morphogenesis
A0003180biological_processaortic valve morphogenesis
A0005114molecular_functiontype II transforming growth factor beta receptor binding
A0005125molecular_functioncytokine activity
A0005160molecular_functiontransforming growth factor beta receptor binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005796cellular_componentGolgi lumen
A0005886cellular_componentplasma membrane
A0005902cellular_componentmicrovillus
A0006611biological_processprotein export from nucleus
A0006754biological_processATP biosynthetic process
A0006796biological_processphosphate-containing compound metabolic process
A0006874biological_processintracellular calcium ion homeostasis
A0006954biological_processinflammatory response
A0007179biological_processtransforming growth factor beta receptor signaling pathway
A0007219biological_processNotch signaling pathway
A0007406biological_processnegative regulation of neuroblast proliferation
A0007435biological_processsalivary gland morphogenesis
A0007492biological_processendoderm development
A0007507biological_processheart development
A0007565biological_processfemale pregnancy
A0008083molecular_functiongrowth factor activity
A0008283biological_processcell population proliferation
A0008284biological_processpositive regulation of cell population proliferation
A0008285biological_processnegative regulation of cell population proliferation
A0008354biological_processgerm cell migration
A0009410biological_processresponse to xenobiotic stimulus
A0009611biological_processresponse to wounding
A0009749biological_processresponse to glucose
A0009986cellular_componentcell surface
A0010033biological_processobsolete response to organic substance
A0010467biological_processgene expression
A0010468biological_processregulation of gene expression
A0010575biological_processpositive regulation of vascular endothelial growth factor production
A0010628biological_processpositive regulation of gene expression
A0010629biological_processnegative regulation of gene expression
A0010716biological_processnegative regulation of extracellular matrix disassembly
A0010718biological_processpositive regulation of epithelial to mesenchymal transition
A0010742biological_processmacrophage derived foam cell differentiation
A0010763biological_processpositive regulation of fibroblast migration
A0010936biological_processnegative regulation of macrophage cytokine production
A0014003biological_processoligodendrocyte development
A0014008biological_processpositive regulation of microglia differentiation
A0014070biological_processresponse to organic cyclic compound
A0016202biological_processregulation of striated muscle tissue development
A0019899molecular_functionenzyme binding
A0021915biological_processneural tube development
A0022408biological_processnegative regulation of cell-cell adhesion
A0030141cellular_componentsecretory granule
A0030214biological_processhyaluronan catabolic process
A0030217biological_processT cell differentiation
A0030279biological_processnegative regulation of ossification
A0030308biological_processnegative regulation of cell growth
A0030316biological_processosteoclast differentiation
A0030334biological_processregulation of cell migration
A0030335biological_processpositive regulation of cell migration
A0030424cellular_componentaxon
A0030879biological_processmammary gland development
A0031012cellular_componentextracellular matrix
A0031093cellular_componentplatelet alpha granule lumen
A0031100biological_processanimal organ regeneration
A0031293biological_processmembrane protein intracellular domain proteolysis
A0031334biological_processpositive regulation of protein-containing complex assembly
A0031536biological_processpositive regulation of exit from mitosis
A0032355biological_processresponse to estradiol
A0032570biological_processresponse to progesterone
A0032667biological_processregulation of interleukin-23 production
A0032700biological_processnegative regulation of interleukin-17 production
A0032740biological_processpositive regulation of interleukin-17 production
A0032755biological_processpositive regulation of interleukin-6 production
A0032760biological_processpositive regulation of tumor necrosis factor production
A0032801biological_processreceptor catabolic process
A0032930biological_processpositive regulation of superoxide anion generation
A0032943biological_processmononuclear cell proliferation
A0032956biological_processregulation of actin cytoskeleton organization
A0032967biological_processpositive regulation of collagen biosynthetic process
A0033280biological_processresponse to vitamin D
A0034616biological_processresponse to laminar fluid shear stress
A0034713molecular_functiontype I transforming growth factor beta receptor binding
A0034714molecular_functiontype III transforming growth factor beta receptor binding
A0035307biological_processpositive regulation of protein dephosphorylation
A0035800molecular_functiondeubiquitinase activator activity
A0035902biological_processresponse to immobilization stress
A0036446biological_processmyofibroblast differentiation
A0042098biological_processT cell proliferation
A0042110biological_processT cell activation
A0042127biological_processregulation of cell population proliferation
A0042130biological_processnegative regulation of T cell proliferation
A0042306biological_processregulation of protein import into nucleus
A0042307biological_processpositive regulation of protein import into nucleus
A0042475biological_processodontogenesis of dentin-containing tooth
A0042482biological_processpositive regulation of odontogenesis
A0042552biological_processmyelination
A0042802molecular_functionidentical protein binding
A0043025cellular_componentneuronal cell body
A0043029biological_processT cell homeostasis
A0043065biological_processpositive regulation of apoptotic process
A0043117biological_processpositive regulation of vascular permeability
A0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
A0043129biological_processsurfactant homeostasis
A0043410biological_processpositive regulation of MAPK cascade
A0043536biological_processpositive regulation of blood vessel endothelial cell migration
A0043537biological_processnegative regulation of blood vessel endothelial cell migration
A0043539molecular_functionprotein serine/threonine kinase activator activity
A0044877molecular_functionprotein-containing complex binding
A0045066biological_processregulatory T cell differentiation
A0045216biological_processcell-cell junction organization
A0045589biological_processregulation of regulatory T cell differentiation
A0045591biological_processpositive regulation of regulatory T cell differentiation
A0045596biological_processnegative regulation of cell differentiation
A0045599biological_processnegative regulation of fat cell differentiation
A0045662biological_processnegative regulation of myoblast differentiation
A0045742biological_processpositive regulation of epidermal growth factor receptor signaling pathway
A0045786biological_processnegative regulation of cell cycle
A0045892biological_processnegative regulation of DNA-templated transcription
A0045893biological_processpositive regulation of DNA-templated transcription
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0046716biological_processmuscle cell cellular homeostasis
A0048146biological_processpositive regulation of fibroblast proliferation
A0048286biological_processlung alveolus development
A0048298biological_processpositive regulation of isotype switching to IgA isotypes
A0048535biological_processlymph node development
A0048565biological_processdigestive tract development
A0048642biological_processnegative regulation of skeletal muscle tissue development
A0048661biological_processpositive regulation of smooth muscle cell proliferation
A0048839biological_processinner ear development
A0050673biological_processepithelial cell proliferation
A0050679biological_processpositive regulation of epithelial cell proliferation
A0050680biological_processnegative regulation of epithelial cell proliferation
A0050714biological_processpositive regulation of protein secretion
A0050729biological_processpositive regulation of inflammatory response
A0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
A0050765biological_processnegative regulation of phagocytosis
A0050832biological_processdefense response to fungus
A0050868biological_processnegative regulation of T cell activation
A0050921biological_processpositive regulation of chemotaxis
A0051152biological_processpositive regulation of smooth muscle cell differentiation
A0051247biological_processpositive regulation of protein metabolic process
A0051280biological_processnegative regulation of release of sequestered calcium ion into cytosol
A0051402biological_processneuron apoptotic process
A0051726biological_processregulation of cell cycle
A0051781biological_processpositive regulation of cell division
A0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A0055010biological_processventricular cardiac muscle tissue morphogenesis
A0055091biological_processphospholipid homeostasis
A0060070biological_processcanonical Wnt signaling pathway
A0060312biological_processregulation of blood vessel remodeling
A0060325biological_processface morphogenesis
A0060364biological_processfrontal suture morphogenesis
A0060391biological_processpositive regulation of SMAD protein signal transduction
A0060435biological_processbronchiole development
A0060744biological_processmammary gland branching involved in thelarche
A0060751biological_processbranch elongation involved in mammary gland duct branching
A0060762biological_processregulation of branching involved in mammary gland duct morphogenesis
A0061035biological_processregulation of cartilage development
A0061298biological_processretina vasculature development in camera-type eye
A0061448biological_processconnective tissue development
A0061520biological_processLangerhans cell differentiation
A0062023cellular_componentcollagen-containing extracellular matrix
A0070168biological_processnegative regulation of biomineral tissue development
A0070173biological_processregulation of enamel mineralization
A0070306biological_processlens fiber cell differentiation
A0070374biological_processpositive regulation of ERK1 and ERK2 cascade
A0070723biological_processresponse to cholesterol
A0071260biological_processcellular response to mechanical stimulus
A0071333biological_processcellular response to glucose stimulus
A0071363biological_processcellular response to growth factor stimulus
A0071404biological_processcellular response to low-density lipoprotein particle stimulus
A0071456biological_processcellular response to hypoxia
A0071479biological_processcellular response to ionizing radiation
A0071549biological_processcellular response to dexamethasone stimulus
A0071560biological_processcellular response to transforming growth factor beta stimulus
A0071677biological_processpositive regulation of mononuclear cell migration
A0071895biological_processodontoblast differentiation
A0072089biological_processstem cell proliferation
A0072562cellular_componentblood microparticle
A0085029biological_processextracellular matrix assembly
A0090190biological_processpositive regulation of branching involved in ureteric bud morphogenesis
A0090263biological_processpositive regulation of canonical Wnt signaling pathway
A0097191biological_processextrinsic apoptotic signaling pathway
A0097421biological_processliver regeneration
A0098586biological_processcellular response to virus
A1900126biological_processnegative regulation of hyaluronan biosynthetic process
A1900182biological_processpositive regulation of protein localization to nucleus
A1901203biological_processpositive regulation of extracellular matrix assembly
A1902074biological_processresponse to salt
A1902462biological_processpositive regulation of mesenchymal stem cell proliferation
A1902893biological_processregulation of miRNA transcription
A1902894biological_processnegative regulation of miRNA transcription
A1902895biological_processpositive regulation of miRNA transcription
A1903077biological_processnegative regulation of protein localization to plasma membrane
A1904018biological_processpositive regulation of vasculature development
A1904894biological_processpositive regulation of receptor signaling pathway via STAT
A1905005biological_processregulation of epithelial to mesenchymal transition involved in endocardial cushion formation
A1990314biological_processcellular response to insulin-like growth factor stimulus
A1990402biological_processembryonic liver development
A2000343biological_processpositive regulation of chemokine (C-X-C motif) ligand 2 production
A2000353biological_processpositive regulation of endothelial cell apoptotic process
A2000636biological_processpositive regulation of primary miRNA processing
A2000648biological_processpositive regulation of stem cell proliferation
A2000727biological_processpositive regulation of cardiac muscle cell differentiation
Functional Information from PROSITE/UniProt
site_idPS00250
Number of Residues16
DetailsTGF_BETA_1 TGF-beta family signature. IhePkgYhanfClGpC
ChainResidueDetails
AILE282-CYS297

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsSITE: Cleavage; by FURIN => ECO:0000269|PubMed:7737999
ChainResidueDetails
AARG249

site_idSWS_FT_FI2
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16263699, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:28117447, ECO:0007744|PDB:5FFO
ChainResidueDetails
AASN53

site_idSWS_FT_FI3
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AGLN107
AGLN147

222415

PDB entries from 2024-07-10

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