5VPV
Crystal structure of Apo Cryptococcus neoformans H99 Acetyl-CoA Synthetase with an Acetylated Active Site Lysine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003987 | molecular_function | acetate-CoA ligase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0006085 | biological_process | acetyl-CoA biosynthetic process |
| A | 0016208 | molecular_function | AMP binding |
| A | 0016874 | molecular_function | ligase activity |
| A | 0019427 | biological_process | acetyl-CoA biosynthetic process from acetate |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0003987 | molecular_function | acetate-CoA ligase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005829 | cellular_component | cytosol |
| B | 0006085 | biological_process | acetyl-CoA biosynthetic process |
| B | 0016208 | molecular_function | AMP binding |
| B | 0016874 | molecular_function | ligase activity |
| B | 0019427 | biological_process | acetyl-CoA biosynthetic process from acetate |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0003987 | molecular_function | acetate-CoA ligase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005829 | cellular_component | cytosol |
| C | 0006085 | biological_process | acetyl-CoA biosynthetic process |
| C | 0016208 | molecular_function | AMP binding |
| C | 0016874 | molecular_function | ligase activity |
| C | 0019427 | biological_process | acetyl-CoA biosynthetic process from acetate |
| C | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 701 |
| Chain | Residue |
| A | PRO167 |
| A | MET168 |
| A | ARG218 |
| A | ASP331 |
| A | GLU356 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue GOL A 702 |
| Chain | Residue |
| A | ARG72 |
| A | LYS82 |
| A | HOH991 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 703 |
| Chain | Residue |
| A | MET392 |
| A | HIS396 |
| A | HOH1003 |
| A | PRO364 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue GOL A 704 |
| Chain | Residue |
| A | TRP334 |
| A | PO4705 |
| A | HOH1001 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue PO4 A 705 |
| Chain | Residue |
| A | THR336 |
| A | TRP439 |
| A | GOL704 |
| A | HOH1001 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue GOL B 701 |
| Chain | Residue |
| B | GLY35 |
| B | GLY38 |
| B | ARG39 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue GOL B 702 |
| Chain | Residue |
| B | HIS43 |
| B | GLU54 |
| B | TYR316 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | binding site for residue PO4 B 703 |
| Chain | Residue |
| B | THR336 |
| B | TRP439 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | binding site for residue GOL C 701 |
| Chain | Residue |
| C | TRP334 |
| C | HOH967 |
| site_id | AD1 |
| Number of Residues | 3 |
| Details | binding site for residue GOL C 702 |
| Chain | Residue |
| C | ARG72 |
| C | PHE81 |
| C | LYS82 |
| site_id | AD2 |
| Number of Residues | 2 |
| Details | binding site for residue PO4 C 703 |
| Chain | Residue |
| C | THR336 |
| C | TRP439 |
| site_id | AD3 |
| Number of Residues | 4 |
| Details | binding site for Di-peptide GLY B 639 and ALY B 640 |
| Chain | Residue |
| B | PRO634 |
| B | LYS635 |
| B | ILE641 |
| B | MET642 |
| site_id | AD4 |
| Number of Residues | 7 |
| Details | binding site for Di-peptide ALY B 640 and ILE B 641 |
| Chain | Residue |
| A | ASP580 |
| B | ALA573 |
| B | PRO634 |
| B | LYS635 |
| B | GLY639 |
| B | MET642 |
| B | ARG643 |
Functional Information from PROSITE/UniProt
| site_id | PS00455 |
| Number of Residues | 12 |
| Details | AMP_BINDING Putative AMP-binding domain signature. ILYTSGSTGkPK |
| Chain | Residue | Details |
| A | ILE286-LYS297 |
