5VOH
Crystal structure of engineered water-forming NADPH oxidase (TPNOX) bound to NADPH. The G159A, D177A, A178R, M179S, P184R mutant of LbNOX.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0016491 | molecular_function | oxidoreductase activity |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0016491 | molecular_function | oxidoreductase activity |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0016491 | molecular_function | oxidoreductase activity |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0016491 | molecular_function | oxidoreductase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 36 |
| Details | binding site for residue FAD A 501 |
| Chain | Residue |
| A | GLY7 |
| A | CSO42 |
| A | HIS77 |
| A | ASN78 |
| A | VAL79 |
| A | THR110 |
| A | SER111 |
| A | GLY112 |
| A | SER113 |
| A | CYS131 |
| A | LYS132 |
| A | THR9 |
| A | ILE158 |
| A | PHE242 |
| A | ASN245 |
| A | LEU248 |
| A | GLY278 |
| A | ASP279 |
| A | PRO295 |
| A | LEU296 |
| A | ALA297 |
| A | ALA300 |
| A | HIS10 |
| A | NDP502 |
| A | HOH609 |
| A | HOH620 |
| A | HOH623 |
| A | HOH634 |
| A | HOH645 |
| B | PHE422 |
| A | ALA11 |
| A | TYR31 |
| A | GLU32 |
| A | ARG33 |
| A | ASN34 |
| A | SER41 |
| site_id | AC2 |
| Number of Residues | 23 |
| Details | binding site for residue NDP A 502 |
| Chain | Residue |
| A | GLY154 |
| A | ALA155 |
| A | GLY156 |
| A | TYR157 |
| A | ILE158 |
| A | GLU161 |
| A | ARG178 |
| A | SER179 |
| A | ARG184 |
| A | LYS185 |
| A | TYR186 |
| A | CYS239 |
| A | ILE240 |
| A | GLY241 |
| A | PHE242 |
| A | PRO295 |
| A | LEU296 |
| A | SER325 |
| A | GLY326 |
| A | FAD501 |
| A | SO4505 |
| A | HOH642 |
| B | HOH610 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 503 |
| Chain | Residue |
| A | ARG332 |
| A | LEU372 |
| A | MET390 |
| A | SER391 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 504 |
| Chain | Residue |
| A | TYR60 |
| A | HOH626 |
| B | PRO429 |
| B | HOH643 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 505 |
| Chain | Residue |
| A | SER179 |
| A | ALA180 |
| A | ARG184 |
| A | NDP502 |
| C | ALA180 |
| C | ARG184 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 506 |
| Chain | Residue |
| A | ARG181 |
| A | ARG184 |
| C | ARG184 |
| site_id | AC7 |
| Number of Residues | 36 |
| Details | binding site for residue FAD B 501 |
| Chain | Residue |
| B | ASN245 |
| B | GLY278 |
| B | ASP279 |
| B | PRO295 |
| B | LEU296 |
| B | ALA297 |
| B | THR298 |
| B | ALA300 |
| B | NDP502 |
| B | HOH611 |
| B | HOH618 |
| B | HOH622 |
| B | HOH635 |
| A | PHE422 |
| A | HOH648 |
| B | GLY7 |
| B | THR9 |
| B | HIS10 |
| B | ALA11 |
| B | TYR31 |
| B | GLU32 |
| B | ARG33 |
| B | ASN34 |
| B | SER41 |
| B | CSO42 |
| B | HIS77 |
| B | ASN78 |
| B | VAL79 |
| B | THR110 |
| B | SER111 |
| B | GLY112 |
| B | SER113 |
| B | CYS131 |
| B | LYS132 |
| B | ILE158 |
| B | PHE242 |
| site_id | AC8 |
| Number of Residues | 21 |
| Details | binding site for residue NDP B 502 |
| Chain | Residue |
| A | GLN423 |
| B | ALA155 |
| B | GLY156 |
| B | TYR157 |
| B | ILE158 |
| B | GLU161 |
| B | ARG178 |
| B | SER179 |
| B | ARG184 |
| B | LYS185 |
| B | TYR186 |
| B | CYS239 |
| B | ILE240 |
| B | GLY241 |
| B | PHE242 |
| B | PRO295 |
| B | LEU296 |
| B | SER325 |
| B | GLY326 |
| B | FAD501 |
| B | HOH623 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | binding site for residue EDO B 503 |
| Chain | Residue |
| B | ARG332 |
| B | MET390 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 504 |
| Chain | Residue |
| A | PRO429 |
| B | PHE14 |
| B | TYR60 |
| B | HOH636 |
| site_id | AD2 |
| Number of Residues | 34 |
| Details | binding site for residue FAD C 501 |
| Chain | Residue |
| C | GLY7 |
| C | CYS8 |
| C | THR9 |
| C | HIS10 |
| C | ALA11 |
| C | GLU32 |
| C | ARG33 |
| C | ASN34 |
| C | SER41 |
| C | CSO42 |
| C | HIS77 |
| C | ASN78 |
| C | VAL79 |
| C | THR110 |
| C | SER111 |
| C | GLY112 |
| C | SER113 |
| C | CYS131 |
| C | LYS132 |
| C | ILE158 |
| C | PHE242 |
| C | ASN245 |
| C | LEU248 |
| C | GLY278 |
| C | ASP279 |
| C | LEU296 |
| C | ALA297 |
| C | THR298 |
| C | ALA300 |
| C | NDP502 |
| C | HOH620 |
| C | HOH636 |
| C | HOH641 |
| D | PHE422 |
| site_id | AD3 |
| Number of Residues | 18 |
| Details | binding site for residue NDP C 502 |
| Chain | Residue |
| C | GLY154 |
| C | ALA155 |
| C | GLY156 |
| C | TYR157 |
| C | ILE158 |
| C | GLU161 |
| C | ALA177 |
| C | ARG178 |
| C | SER179 |
| C | TYR186 |
| C | CYS239 |
| C | ILE240 |
| C | GLY241 |
| C | PRO295 |
| C | LEU296 |
| C | GLY326 |
| C | FAD501 |
| D | GLN423 |
| site_id | AD4 |
| Number of Residues | 6 |
| Details | binding site for residue EDO C 503 |
| Chain | Residue |
| C | ARG332 |
| C | GLU357 |
| C | PRO370 |
| C | MET390 |
| C | SER391 |
| C | HOH627 |
| site_id | AD5 |
| Number of Residues | 3 |
| Details | binding site for residue EDO C 504 |
| Chain | Residue |
| C | ARG428 |
| C | PRO429 |
| C | HOH640 |
| site_id | AD6 |
| Number of Residues | 35 |
| Details | binding site for residue FAD D 501 |
| Chain | Residue |
| C | PHE422 |
| C | GLN423 |
| D | GLY7 |
| D | CYS8 |
| D | THR9 |
| D | HIS10 |
| D | ALA11 |
| D | GLU32 |
| D | ARG33 |
| D | ASN34 |
| D | SER41 |
| D | CSO42 |
| D | HIS77 |
| D | ASN78 |
| D | VAL79 |
| D | THR110 |
| D | SER111 |
| D | GLY112 |
| D | SER113 |
| D | CYS131 |
| D | LYS132 |
| D | PHE242 |
| D | LEU248 |
| D | GLY278 |
| D | ASP279 |
| D | PRO295 |
| D | LEU296 |
| D | ALA297 |
| D | ALA300 |
| D | NDP502 |
| D | HOH613 |
| D | HOH630 |
| D | HOH635 |
| D | HOH637 |
| D | HOH652 |
| site_id | AD7 |
| Number of Residues | 18 |
| Details | binding site for residue NDP D 502 |
| Chain | Residue |
| C | HOH609 |
| D | ALA155 |
| D | GLY156 |
| D | TYR157 |
| D | ILE158 |
| D | ARG178 |
| D | SER179 |
| D | ARG184 |
| D | LYS185 |
| D | TYR186 |
| D | ILE240 |
| D | GLY241 |
| D | PHE242 |
| D | PRO295 |
| D | LEU296 |
| D | SER325 |
| D | GLY326 |
| D | FAD501 |
| site_id | AD8 |
| Number of Residues | 5 |
| Details | binding site for residue EDO D 503 |
| Chain | Residue |
| C | PHE14 |
| C | TYR60 |
| D | ARG428 |
| D | PRO429 |
| D | HOH645 |
| site_id | AD9 |
| Number of Residues | 3 |
| Details | binding site for residue EDO D 504 |
| Chain | Residue |
| D | ARG332 |
| D | MET390 |
| D | SER391 |
| site_id | AE1 |
| Number of Residues | 2 |
| Details | binding site for residue CL D 505 |
| Chain | Residue |
| B | ARG184 |
| D | ARG181 |
