5VM5
Engineered tryptophan synthase b-subunit from Pyrococcus furiosus, PfTrpB2B9, with Ser bound
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000162 | biological_process | L-tryptophan biosynthetic process |
| A | 0004834 | molecular_function | tryptophan synthase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006568 | biological_process | L-tryptophan metabolic process |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| A | 0016829 | molecular_function | lyase activity |
| B | 0000162 | biological_process | L-tryptophan biosynthetic process |
| B | 0004834 | molecular_function | tryptophan synthase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006568 | biological_process | L-tryptophan metabolic process |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| B | 0016829 | molecular_function | lyase activity |
| C | 0000162 | biological_process | L-tryptophan biosynthetic process |
| C | 0004834 | molecular_function | tryptophan synthase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006568 | biological_process | L-tryptophan metabolic process |
| C | 0008652 | biological_process | amino acid biosynthetic process |
| C | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| C | 0016829 | molecular_function | lyase activity |
| D | 0000162 | biological_process | L-tryptophan biosynthetic process |
| D | 0004834 | molecular_function | tryptophan synthase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006568 | biological_process | L-tryptophan metabolic process |
| D | 0008652 | biological_process | amino acid biosynthetic process |
| D | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| D | 0016829 | molecular_function | lyase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 21 |
| Details | binding site for residue PLS A 401 |
| Chain | Residue |
| A | HIS81 |
| A | GLY227 |
| A | GLY228 |
| A | GLY229 |
| A | SER230 |
| A | ASN231 |
| A | GLY298 |
| A | ASP300 |
| A | GLU345 |
| A | SER371 |
| A | HOH535 |
| A | LYS82 |
| A | HOH569 |
| A | HOH605 |
| A | THR105 |
| A | GLY106 |
| A | ALA107 |
| A | GLY108 |
| A | GLN109 |
| A | HIS110 |
| A | SER185 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue NA A 402 |
| Chain | Residue |
| A | GLY227 |
| A | SER263 |
| A | SER265 |
| A | TYR301 |
| A | GLY303 |
| A | HOH570 |
| A | HOH585 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue NA A 403 |
| Chain | Residue |
| A | GLY48 |
| A | PRO50 |
| A | HOH636 |
| B | GLY48 |
| B | PRO50 |
| B | HOH627 |
| site_id | AC4 |
| Number of Residues | 20 |
| Details | binding site for residue PLS B 401 |
| Chain | Residue |
| B | HIS81 |
| B | LYS82 |
| B | THR105 |
| B | GLY106 |
| B | ALA107 |
| B | GLY108 |
| B | GLN109 |
| B | HIS110 |
| B | SER185 |
| B | GLY227 |
| B | GLY228 |
| B | GLY229 |
| B | SER230 |
| B | ASN231 |
| B | GLY298 |
| B | ASP300 |
| B | GLU345 |
| B | SER371 |
| B | HOH534 |
| B | HOH573 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue NA B 402 |
| Chain | Residue |
| B | SER263 |
| B | SER265 |
| B | TYR301 |
| B | GLY303 |
| B | HOH589 |
| B | HOH601 |
| site_id | AC6 |
| Number of Residues | 21 |
| Details | binding site for residue PLS C 401 |
| Chain | Residue |
| C | HIS81 |
| C | LYS82 |
| C | THR105 |
| C | GLY106 |
| C | ALA107 |
| C | GLY108 |
| C | GLN109 |
| C | HIS110 |
| C | SER185 |
| C | GLY227 |
| C | GLY228 |
| C | GLY229 |
| C | SER230 |
| C | ASN231 |
| C | GLY298 |
| C | ASP300 |
| C | GLU345 |
| C | SER371 |
| C | HOH534 |
| C | HOH551 |
| C | HOH579 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue NA C 402 |
| Chain | Residue |
| C | SER263 |
| C | SER265 |
| C | TYR301 |
| C | GLY303 |
| C | HOH556 |
| C | HOH576 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | binding site for residue NA C 403 |
| Chain | Residue |
| A | TRP2 |
| A | GLY4 |
| A | GLU5 |
| A | HOH516 |
| C | GLN283 |
| C | GLY287 |
| C | HOH631 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue NA C 404 |
| Chain | Residue |
| D | HOH638 |
| C | GLY48 |
| C | PRO50 |
| C | HOH634 |
| D | GLY48 |
| D | PRO50 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue NA D 401 |
| Chain | Residue |
| D | SER263 |
| D | SER265 |
| D | TYR301 |
| D | GLY303 |
| D | HOH570 |
| D | HOH605 |
| site_id | AD2 |
| Number of Residues | 20 |
| Details | binding site for residue 0JO D 402 |
| Chain | Residue |
| D | HIS81 |
| D | LYS82 |
| D | THR105 |
| D | GLY106 |
| D | ALA107 |
| D | GLY108 |
| D | GLN109 |
| D | HIS110 |
| D | SER185 |
| D | CYS225 |
| D | GLY227 |
| D | GLY228 |
| D | GLY229 |
| D | SER230 |
| D | ASN231 |
| D | GLY298 |
| D | GLU345 |
| D | SER371 |
| D | HOH514 |
| D | HOH545 |
Functional Information from PROSITE/UniProt
| site_id | PS00168 |
| Number of Residues | 15 |
| Details | TRP_SYNTHASE_BETA Tryptophan synthase beta chain pyridoxal-phosphate attachment site. LvHgGAHKtNnaIgQ |
| Chain | Residue | Details |
| A | LEU75-GLN89 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N6-(pyridoxal phosphate)lysine","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
