5VL1

Crystal Structure of Lysyl-tRNA Synthetase from Mycobacterium ulcerans complexed with L-lysine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000049	molecular_function	tRNA binding
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0003676	molecular_function	nucleic acid binding
A	0004812	molecular_function	aminoacyl-tRNA ligase activity
A	0004824	molecular_function	lysine-tRNA ligase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006412	biological_process	translation
A	0006418	biological_process	tRNA aminoacylation for protein translation
A	0006430	biological_process	lysyl-tRNA aminoacylation
A	0016874	molecular_function	ligase activity
A	0046872	molecular_function	metal ion binding
B	0000049	molecular_function	tRNA binding
B	0000166	molecular_function	nucleotide binding
B	0000287	molecular_function	magnesium ion binding
B	0003676	molecular_function	nucleic acid binding
B	0004812	molecular_function	aminoacyl-tRNA ligase activity
B	0004824	molecular_function	lysine-tRNA ligase activity
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006412	biological_process	translation
B	0006418	biological_process	tRNA aminoacylation for protein translation
B	0006430	biological_process	lysyl-tRNA aminoacylation
B	0016874	molecular_function	ligase activity
B	0046872	molecular_function	metal ion binding
C	0000049	molecular_function	tRNA binding
C	0000166	molecular_function	nucleotide binding
C	0000287	molecular_function	magnesium ion binding
C	0003676	molecular_function	nucleic acid binding
C	0004812	molecular_function	aminoacyl-tRNA ligase activity
C	0004824	molecular_function	lysine-tRNA ligase activity
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006412	biological_process	translation
C	0006418	biological_process	tRNA aminoacylation for protein translation
C	0006430	biological_process	lysyl-tRNA aminoacylation
C	0016874	molecular_function	ligase activity
C	0046872	molecular_function	metal ion binding
D	0000049	molecular_function	tRNA binding
D	0000166	molecular_function	nucleotide binding
D	0000287	molecular_function	magnesium ion binding
D	0003676	molecular_function	nucleic acid binding
D	0004812	molecular_function	aminoacyl-tRNA ligase activity
D	0004824	molecular_function	lysine-tRNA ligase activity
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006412	biological_process	translation
D	0006418	biological_process	tRNA aminoacylation for protein translation
D	0006430	biological_process	lysyl-tRNA aminoacylation
D	0016874	molecular_function	ligase activity
D	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue PGE A 501

Chain	Residue
A	HIS263
A	SER264
A	PHE267
A	GLU415
A	LEU416
A	ASP473
A	ARG474

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site_id	AC2
Number of Residues	12
Details	binding site for residue LYS A 502

Chain	Residue
A	GLU233
A	ARG255
A	MET269
A	GLU271
A	TYR273
A	THR418
A	TYR420
A	GLU422
A	GLY467
A	GLY469
A	GLY209
A	ALA210

---

site_id	AC3
Number of Residues	3
Details	binding site for residue PEG A 503

Chain	Residue
A	PRO9
A	GLU10
A	GLN11

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site_id	AC4
Number of Residues	5
Details	binding site for residue PEG A 504

Chain	Residue
A	ARG395
A	HIS397
A	ARG398
A	SER399
B	ASP28

---

site_id	AC5
Number of Residues	5
Details	binding site for residue PGE B 501

Chain	Residue
B	THR262
B	PHE267
B	LEU416
B	ASP473
B	ARG474

---

site_id	AC6
Number of Residues	10
Details	binding site for residue LYS B 502

Chain	Residue
B	GLY209
B	GLU233
B	ARG255
B	MET269
B	GLU271
B	TYR273
B	TYR420
B	GLU422
B	GLY467
B	GLY469

---

site_id	AC7
Number of Residues	1
Details	binding site for residue PEG B 503

Chain	Residue
B	GLU25

---

site_id	AC8
Number of Residues	6
Details	binding site for residue PGE C 501

Chain	Residue
C	HIS263
C	SER264
C	PHE267
C	GLU415
C	ASP473
C	ARG474

---

site_id	AC9
Number of Residues	11
Details	binding site for residue LYS C 502

Chain	Residue
C	GLY209
C	GLU233
C	ARG255
C	MET269
C	GLU271
C	TYR273
C	THR418
C	TYR420
C	GLU422
C	GLY467
C	GLY469

---

site_id	AD1
Number of Residues	3
Details	binding site for residue PGE D 501

Chain	Residue
D	THR262
D	PHE267
D	ARG474

---

site_id	AD2
Number of Residues	10
Details	binding site for residue LYS D 502

Chain	Residue
D	GLY209
D	ALA210
D	GLU233
D	ARG255
D	MET269
D	GLU271
D	TYR273
D	TYR420
D	GLU422
D	GLY467

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