5VFI
Bruton's tyrosine kinase (BTK) with GDC-0853
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | binding site for residue EDO A 702 |
| Chain | Residue |
| A | ARG520 |
| A | HOH882 |
| A | LEU522 |
| A | TRP563 |
| A | SER564 |
| A | PHE574 |
| A | SER578 |
| A | ALA582 |
| A | HOH803 |
| A | HOH820 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 703 |
| Chain | Residue |
| A | ARG492 |
| A | PHE493 |
| A | SER572 |
| A | LEU593 |
| A | HOH853 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 704 |
| Chain | Residue |
| A | GLN494 |
| A | GLN496 |
| A | SER575 |
| A | SER576 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 705 |
| Chain | Residue |
| A | TYR476 |
| A | MET477 |
| A | ALA478 |
| A | ASN530 |
| A | ASP531 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 706 |
| Chain | Residue |
| A | THR495 |
| A | GLU658 |
| A | HOH847 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 707 |
| Chain | Residue |
| A | THR403 |
| A | PHE404 |
| A | TYR627 |
| A | THR628 |
| A | TYR631 |
| A | HOH816 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 708 |
| Chain | Residue |
| A | GLN494 |
| A | GLN497 |
| A | GLN516 |
| A | PHE517 |
| A | LEU518 |
| A | ARG520 |
| A | HOH823 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 709 |
| Chain | Residue |
| A | TYR598 |
| A | GLU599 |
| A | ARG600 |
| A | PHE601 |
| A | HOH879 |
| A | HOH886 |
| A | HOH889 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 710 |
| Chain | Residue |
| A | GLY389 |
| A | ARG422 |
| A | HOH880 |
| A | HOH924 |
| A | HOH953 |
| site_id | AD1 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 A 711 |
| Chain | Residue |
| A | LYS595 |
| A | PRO619 |
| A | HIS620 |
| A | HOH809 |
| A | HOH814 |
| A | HOH821 |
| A | HOH833 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 23 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGTGQFGVVKyGkwrgqyd...........VAIK |
| Chain | Residue | Details |
| A | LEU408-LYS430 |
| site_id | PS00109 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. FLHrDLAARNCLV |
| Chain | Residue | Details |
| A | PHE517-VAL529 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 253 |
| Details | Domain: {"description":"Protein kinase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 7 |
| Details | Motif: {"description":"CAV1-binding"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10028","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 9 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"20052711","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3K54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3OCT","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21280133","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3PIY","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine; by LYN and SYK","evidences":[{"source":"PubMed","id":"8630736","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9012831","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15375214","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"15375214","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
