5VFI

Bruton's tyrosine kinase (BTK) with GDC-0853

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004713	molecular_function	protein tyrosine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	binding site for residue EDO A 702

Chain	Residue
A	ARG520
A	HOH882
A	LEU522
A	TRP563
A	SER564
A	PHE574
A	SER578
A	ALA582
A	HOH803
A	HOH820

---

site_id	AC2
Number of Residues	5
Details	binding site for residue EDO A 703

Chain	Residue
A	ARG492
A	PHE493
A	SER572
A	LEU593
A	HOH853

---

site_id	AC3
Number of Residues	4
Details	binding site for residue EDO A 704

Chain	Residue
A	GLN494
A	GLN496
A	SER575
A	SER576

---

site_id	AC4
Number of Residues	5
Details	binding site for residue EDO A 705

Chain	Residue
A	TYR476
A	MET477
A	ALA478
A	ASN530
A	ASP531

---

site_id	AC5
Number of Residues	3
Details	binding site for residue EDO A 706

Chain	Residue
A	THR495
A	GLU658
A	HOH847

---

site_id	AC6
Number of Residues	6
Details	binding site for residue EDO A 707

Chain	Residue
A	THR403
A	PHE404
A	TYR627
A	THR628
A	TYR631
A	HOH816

---

site_id	AC7
Number of Residues	7
Details	binding site for residue EDO A 708

Chain	Residue
A	GLN494
A	GLN497
A	GLN516
A	PHE517
A	LEU518
A	ARG520
A	HOH823

---

site_id	AC8
Number of Residues	7
Details	binding site for residue EDO A 709

Chain	Residue
A	TYR598
A	GLU599
A	ARG600
A	PHE601
A	HOH879
A	HOH886
A	HOH889

---

site_id	AC9
Number of Residues	5
Details	binding site for residue SO4 A 710

Chain	Residue
A	GLY389
A	ARG422
A	HOH880
A	HOH924
A	HOH953

---

site_id	AD1
Number of Residues	7
Details	binding site for residue SO4 A 711

Chain	Residue
A	LYS595
A	PRO619
A	HIS620
A	HOH809
A	HOH814
A	HOH821
A	HOH833

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	23
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGTGQFGVVKyGkwrgqyd...........VAIK

Chain	Residue	Details
A	LEU408-LYS430

---

site_id	PS00109
Number of Residues	13
Details	PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. FLHrDLAARNCLV

Chain	Residue	Details
A	PHE517-VAL529

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028

Chain	Residue	Details
A	ARG487

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
A	GLU396

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:20052711, ECO:0007744|PDB:3K54, ECO:0007744|PDB:3OCT

Chain	Residue	Details
A	ASP440

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:21280133, ECO:0007744|PDB:3PIY

Chain	Residue	Details
A	ALA508

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphotyrosine; by LYN and SYK => ECO:0000269|PubMed:8630736, ECO:0000269|PubMed:9012831

Chain	Residue	Details
A	PHE517

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	MET570

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:15375214

Chain	Residue	Details
A	PHE583

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:15375214

Chain	Residue	Details
A	GLU589

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19369195

Chain	Residue	Details
A	LYS625

---