5VEA

HIV Protease (PR) with TL-3 in active site and 4-methylbenzene-1,2-diamine in exosite

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004190	molecular_function	aspartic-type endopeptidase activity
A	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	binding site for residue 3TL A 101

Chain	Residue
A	ARG8
A	GLY48
A	GLY49
A	ILE50
A	ILE50
A	PRO81
A	ILE84
A	HOH205
A	HOH205
A	ASP25
A	ASP25
A	GLY27
A	ALA28
A	ASP29
A	ASP30
A	MET46
A	ILE47

---

site_id	AC2
Number of Residues	6
Details	binding site for residue 9AY A 102

Chain	Residue
A	PRO39
A	ASP60
A	GLN61
A	ILE62
A	DMS104
A	HOH247

---

site_id	AC3
Number of Residues	9
Details	binding site for residue DMS A 103

Chain	Residue
A	THR12
A	THR12
A	ILE13
A	LYS14
A	LEU19
A	GLU65
A	ILE66
A	CYS67
A	GLY68

---

site_id	AC4
Number of Residues	8
Details	binding site for residue DMS A 104

Chain	Residue
A	PRO39
A	GLN61
A	ILE62
A	LEU63
A	LYS70
A	9AY102
A	HOH209
A	HOH233

---

site_id	AC5
Number of Residues	2
Details	binding site for residue DMS A 105

Chain	Residue
A	GLY51
A	ILE54

---

Functional Information from PROSITE/UniProt

site_id	PS00141
Number of Residues	12
Details	ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ALLDTGADDTVL

Chain	Residue	Details
A	ALA22-LEU33

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI2
Number of Residues	10
Details	Region: {"description":"Dimerization of protease","evidences":[{"source":"UniProtKB","id":"P04585","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Active site: {"description":"For protease activity; shared with dimeric partner","evidences":[{"source":"PROSITE-ProRule","id":"PRU10094","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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