5VCB

Crystal structure of holo-(acyl-carrier-protein) synthase:holo(acyl-carrier-protein) complex from Escherichia Coli.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0005737	cellular_component	cytoplasm
A	0006629	biological_process	lipid metabolic process
A	0006631	biological_process	fatty acid metabolic process
A	0006633	biological_process	fatty acid biosynthetic process
A	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
A	0016740	molecular_function	transferase activity
A	0046872	molecular_function	metal ion binding
B	0000287	molecular_function	magnesium ion binding
B	0005737	cellular_component	cytoplasm
B	0006629	biological_process	lipid metabolic process
B	0006631	biological_process	fatty acid metabolic process
B	0006633	biological_process	fatty acid biosynthetic process
B	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
B	0016740	molecular_function	transferase activity
B	0046872	molecular_function	metal ion binding
C	0000287	molecular_function	magnesium ion binding
C	0005737	cellular_component	cytoplasm
C	0006629	biological_process	lipid metabolic process
C	0006631	biological_process	fatty acid metabolic process
C	0006633	biological_process	fatty acid biosynthetic process
C	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
C	0016740	molecular_function	transferase activity
C	0046872	molecular_function	metal ion binding
D	0000035	molecular_function	acyl binding
D	0000036	molecular_function	acyl carrier activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006629	biological_process	lipid metabolic process
D	0006631	biological_process	fatty acid metabolic process
D	0006633	biological_process	fatty acid biosynthetic process
D	0008289	molecular_function	lipid binding
D	0008610	biological_process	lipid biosynthetic process
D	0009245	biological_process	lipid A biosynthetic process
D	0009410	biological_process	response to xenobiotic stimulus
D	0016020	cellular_component	membrane
D	0031177	molecular_function	phosphopantetheine binding
E	0000035	molecular_function	acyl binding
E	0000036	molecular_function	acyl carrier activity
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006629	biological_process	lipid metabolic process
E	0006631	biological_process	fatty acid metabolic process
E	0006633	biological_process	fatty acid biosynthetic process
E	0008289	molecular_function	lipid binding
E	0008610	biological_process	lipid biosynthetic process
E	0009245	biological_process	lipid A biosynthetic process
E	0009410	biological_process	response to xenobiotic stimulus
E	0016020	cellular_component	membrane
E	0031177	molecular_function	phosphopantetheine binding
F	0000035	molecular_function	acyl binding
F	0000036	molecular_function	acyl carrier activity
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006629	biological_process	lipid metabolic process
F	0006631	biological_process	fatty acid metabolic process
F	0006633	biological_process	fatty acid biosynthetic process
F	0008289	molecular_function	lipid binding
F	0008610	biological_process	lipid biosynthetic process
F	0009245	biological_process	lipid A biosynthetic process
F	0009410	biological_process	response to xenobiotic stimulus
F	0016020	cellular_component	membrane
F	0031177	molecular_function	phosphopantetheine binding
G	0000287	molecular_function	magnesium ion binding
G	0005737	cellular_component	cytoplasm
G	0006629	biological_process	lipid metabolic process
G	0006631	biological_process	fatty acid metabolic process
G	0006633	biological_process	fatty acid biosynthetic process
G	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
G	0016740	molecular_function	transferase activity
G	0046872	molecular_function	metal ion binding
H	0000287	molecular_function	magnesium ion binding
H	0005737	cellular_component	cytoplasm
H	0006629	biological_process	lipid metabolic process
H	0006631	biological_process	fatty acid metabolic process
H	0006633	biological_process	fatty acid biosynthetic process
H	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
H	0016740	molecular_function	transferase activity
H	0046872	molecular_function	metal ion binding
I	0000287	molecular_function	magnesium ion binding
I	0005737	cellular_component	cytoplasm
I	0006629	biological_process	lipid metabolic process
I	0006631	biological_process	fatty acid metabolic process
I	0006633	biological_process	fatty acid biosynthetic process
I	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
I	0016740	molecular_function	transferase activity
I	0046872	molecular_function	metal ion binding
J	0000035	molecular_function	acyl binding
J	0000036	molecular_function	acyl carrier activity
J	0005515	molecular_function	protein binding
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0006629	biological_process	lipid metabolic process
J	0006631	biological_process	fatty acid metabolic process
J	0006633	biological_process	fatty acid biosynthetic process
J	0008289	molecular_function	lipid binding
J	0008610	biological_process	lipid biosynthetic process
J	0009245	biological_process	lipid A biosynthetic process
J	0009410	biological_process	response to xenobiotic stimulus
J	0016020	cellular_component	membrane
J	0031177	molecular_function	phosphopantetheine binding
K	0000035	molecular_function	acyl binding
K	0000036	molecular_function	acyl carrier activity
K	0005515	molecular_function	protein binding
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0006629	biological_process	lipid metabolic process
K	0006631	biological_process	fatty acid metabolic process
K	0006633	biological_process	fatty acid biosynthetic process
K	0008289	molecular_function	lipid binding
K	0008610	biological_process	lipid biosynthetic process
K	0009245	biological_process	lipid A biosynthetic process
K	0009410	biological_process	response to xenobiotic stimulus
K	0016020	cellular_component	membrane
K	0031177	molecular_function	phosphopantetheine binding
L	0000035	molecular_function	acyl binding
L	0000036	molecular_function	acyl carrier activity
L	0005515	molecular_function	protein binding
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0006629	biological_process	lipid metabolic process
L	0006631	biological_process	fatty acid metabolic process
L	0006633	biological_process	fatty acid biosynthetic process
L	0008289	molecular_function	lipid binding
L	0008610	biological_process	lipid biosynthetic process
L	0009245	biological_process	lipid A biosynthetic process
L	0009410	biological_process	response to xenobiotic stimulus
L	0016020	cellular_component	membrane
L	0031177	molecular_function	phosphopantetheine binding
M	0000287	molecular_function	magnesium ion binding
M	0005737	cellular_component	cytoplasm
M	0006629	biological_process	lipid metabolic process
M	0006631	biological_process	fatty acid metabolic process
M	0006633	biological_process	fatty acid biosynthetic process
M	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
M	0016740	molecular_function	transferase activity
M	0046872	molecular_function	metal ion binding
N	0000287	molecular_function	magnesium ion binding
N	0005737	cellular_component	cytoplasm
N	0006629	biological_process	lipid metabolic process
N	0006631	biological_process	fatty acid metabolic process
N	0006633	biological_process	fatty acid biosynthetic process
N	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
N	0016740	molecular_function	transferase activity
N	0046872	molecular_function	metal ion binding
O	0000287	molecular_function	magnesium ion binding
O	0005737	cellular_component	cytoplasm
O	0006629	biological_process	lipid metabolic process
O	0006631	biological_process	fatty acid metabolic process
O	0006633	biological_process	fatty acid biosynthetic process
O	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
O	0016740	molecular_function	transferase activity
O	0046872	molecular_function	metal ion binding
P	0000035	molecular_function	acyl binding
P	0000036	molecular_function	acyl carrier activity
P	0005515	molecular_function	protein binding
P	0005737	cellular_component	cytoplasm
P	0005829	cellular_component	cytosol
P	0006629	biological_process	lipid metabolic process
P	0006631	biological_process	fatty acid metabolic process
P	0006633	biological_process	fatty acid biosynthetic process
P	0008289	molecular_function	lipid binding
P	0008610	biological_process	lipid biosynthetic process
P	0009245	biological_process	lipid A biosynthetic process
P	0009410	biological_process	response to xenobiotic stimulus
P	0016020	cellular_component	membrane
P	0031177	molecular_function	phosphopantetheine binding
Q	0000035	molecular_function	acyl binding
Q	0000036	molecular_function	acyl carrier activity
Q	0005515	molecular_function	protein binding
Q	0005737	cellular_component	cytoplasm
Q	0005829	cellular_component	cytosol
Q	0006629	biological_process	lipid metabolic process
Q	0006631	biological_process	fatty acid metabolic process
Q	0006633	biological_process	fatty acid biosynthetic process
Q	0008289	molecular_function	lipid binding
Q	0008610	biological_process	lipid biosynthetic process
Q	0009245	biological_process	lipid A biosynthetic process
Q	0009410	biological_process	response to xenobiotic stimulus
Q	0016020	cellular_component	membrane
Q	0031177	molecular_function	phosphopantetheine binding
R	0000035	molecular_function	acyl binding
R	0000036	molecular_function	acyl carrier activity
R	0005515	molecular_function	protein binding
R	0005737	cellular_component	cytoplasm
R	0005829	cellular_component	cytosol
R	0006629	biological_process	lipid metabolic process
R	0006631	biological_process	fatty acid metabolic process
R	0006633	biological_process	fatty acid biosynthetic process
R	0008289	molecular_function	lipid binding
R	0008610	biological_process	lipid biosynthetic process
R	0009245	biological_process	lipid A biosynthetic process
R	0009410	biological_process	response to xenobiotic stimulus
R	0016020	cellular_component	membrane
R	0031177	molecular_function	phosphopantetheine binding
S	0000287	molecular_function	magnesium ion binding
S	0005737	cellular_component	cytoplasm
S	0006629	biological_process	lipid metabolic process
S	0006631	biological_process	fatty acid metabolic process
S	0006633	biological_process	fatty acid biosynthetic process
S	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
S	0016740	molecular_function	transferase activity
S	0046872	molecular_function	metal ion binding
T	0000287	molecular_function	magnesium ion binding
T	0005737	cellular_component	cytoplasm
T	0006629	biological_process	lipid metabolic process
T	0006631	biological_process	fatty acid metabolic process
T	0006633	biological_process	fatty acid biosynthetic process
T	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
T	0016740	molecular_function	transferase activity
T	0046872	molecular_function	metal ion binding
U	0000287	molecular_function	magnesium ion binding
U	0005737	cellular_component	cytoplasm
U	0006629	biological_process	lipid metabolic process
U	0006631	biological_process	fatty acid metabolic process
U	0006633	biological_process	fatty acid biosynthetic process
U	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
U	0016740	molecular_function	transferase activity
U	0046872	molecular_function	metal ion binding
V	0000035	molecular_function	acyl binding
V	0000036	molecular_function	acyl carrier activity
V	0005515	molecular_function	protein binding
V	0005737	cellular_component	cytoplasm
V	0005829	cellular_component	cytosol
V	0006629	biological_process	lipid metabolic process
V	0006631	biological_process	fatty acid metabolic process
V	0006633	biological_process	fatty acid biosynthetic process
V	0008289	molecular_function	lipid binding
V	0008610	biological_process	lipid biosynthetic process
V	0009245	biological_process	lipid A biosynthetic process
V	0009410	biological_process	response to xenobiotic stimulus
V	0016020	cellular_component	membrane
V	0031177	molecular_function	phosphopantetheine binding
W	0000035	molecular_function	acyl binding
W	0000036	molecular_function	acyl carrier activity
W	0005515	molecular_function	protein binding
W	0005737	cellular_component	cytoplasm
W	0005829	cellular_component	cytosol
W	0006629	biological_process	lipid metabolic process
W	0006631	biological_process	fatty acid metabolic process
W	0006633	biological_process	fatty acid biosynthetic process
W	0008289	molecular_function	lipid binding
W	0008610	biological_process	lipid biosynthetic process
W	0009245	biological_process	lipid A biosynthetic process
W	0009410	biological_process	response to xenobiotic stimulus
W	0016020	cellular_component	membrane
W	0031177	molecular_function	phosphopantetheine binding
X	0000035	molecular_function	acyl binding
X	0000036	molecular_function	acyl carrier activity
X	0005515	molecular_function	protein binding
X	0005737	cellular_component	cytoplasm
X	0005829	cellular_component	cytosol
X	0006629	biological_process	lipid metabolic process
X	0006631	biological_process	fatty acid metabolic process
X	0006633	biological_process	fatty acid biosynthetic process
X	0008289	molecular_function	lipid binding
X	0008610	biological_process	lipid biosynthetic process
X	0009245	biological_process	lipid A biosynthetic process
X	0009410	biological_process	response to xenobiotic stimulus
X	0016020	cellular_component	membrane
X	0031177	molecular_function	phosphopantetheine binding
a	0000287	molecular_function	magnesium ion binding
a	0005737	cellular_component	cytoplasm
a	0006629	biological_process	lipid metabolic process
a	0006631	biological_process	fatty acid metabolic process
a	0006633	biological_process	fatty acid biosynthetic process
a	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
a	0016740	molecular_function	transferase activity
a	0046872	molecular_function	metal ion binding
b	0000287	molecular_function	magnesium ion binding
b	0005737	cellular_component	cytoplasm
b	0006629	biological_process	lipid metabolic process
b	0006631	biological_process	fatty acid metabolic process
b	0006633	biological_process	fatty acid biosynthetic process
b	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
b	0016740	molecular_function	transferase activity
b	0046872	molecular_function	metal ion binding
c	0000287	molecular_function	magnesium ion binding
c	0005737	cellular_component	cytoplasm
c	0006629	biological_process	lipid metabolic process
c	0006631	biological_process	fatty acid metabolic process
c	0006633	biological_process	fatty acid biosynthetic process
c	0008897	molecular_function	holo-[acyl-carrier-protein] synthase activity
c	0016740	molecular_function	transferase activity
c	0046872	molecular_function	metal ion binding
d	0000035	molecular_function	acyl binding
d	0000036	molecular_function	acyl carrier activity
d	0005515	molecular_function	protein binding
d	0005737	cellular_component	cytoplasm
d	0005829	cellular_component	cytosol
d	0006629	biological_process	lipid metabolic process
d	0006631	biological_process	fatty acid metabolic process
d	0006633	biological_process	fatty acid biosynthetic process
d	0008289	molecular_function	lipid binding
d	0008610	biological_process	lipid biosynthetic process
d	0009245	biological_process	lipid A biosynthetic process
d	0009410	biological_process	response to xenobiotic stimulus
d	0016020	cellular_component	membrane
d	0031177	molecular_function	phosphopantetheine binding
e	0000035	molecular_function	acyl binding
e	0000036	molecular_function	acyl carrier activity
e	0005515	molecular_function	protein binding
e	0005737	cellular_component	cytoplasm
e	0005829	cellular_component	cytosol
e	0006629	biological_process	lipid metabolic process
e	0006631	biological_process	fatty acid metabolic process
e	0006633	biological_process	fatty acid biosynthetic process
e	0008289	molecular_function	lipid binding
e	0008610	biological_process	lipid biosynthetic process
e	0009245	biological_process	lipid A biosynthetic process
e	0009410	biological_process	response to xenobiotic stimulus
e	0016020	cellular_component	membrane
e	0031177	molecular_function	phosphopantetheine binding
f	0000035	molecular_function	acyl binding
f	0000036	molecular_function	acyl carrier activity
f	0005515	molecular_function	protein binding
f	0005737	cellular_component	cytoplasm
f	0005829	cellular_component	cytosol
f	0006629	biological_process	lipid metabolic process
f	0006631	biological_process	fatty acid metabolic process
f	0006633	biological_process	fatty acid biosynthetic process
f	0008289	molecular_function	lipid binding
f	0008610	biological_process	lipid biosynthetic process
f	0009245	biological_process	lipid A biosynthetic process
f	0009410	biological_process	response to xenobiotic stimulus
f	0016020	cellular_component	membrane
f	0031177	molecular_function	phosphopantetheine binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue PNS J 101

Chain	Residue
G	GLU58
G	LYS62
H	ASP113
J	SER36

---

site_id	AC2
Number of Residues	6
Details	binding site for residue PNS D 101

Chain	Residue
D	GLU60
A	GLU58
A	LYS62
D	VAL29
D	ASP35
D	SER36

---

site_id	AC3
Number of Residues	7
Details	binding site for residue PNS P 101

Chain	Residue
M	GLU58
M	LYS62
N	ALA112
N	ASP113
P	VAL29
P	SER36
P	THR39

---

site_id	AC4
Number of Residues	6
Details

Chain	Residue
B	GLU58
B	LYS62
C	ALA112
C	ASP113
E	ASP35
E	LEU37

---

site_id	AC5
Number of Residues	7
Details

Chain	Residue
A	ALA112
A	ASP113
C	LYS62
F	ASP35
F	LEU37
F	THR39
F	GLU60

---

site_id	AC6
Number of Residues	33
Details

Chain	Residue
G	VAL11
G	GLU12
G	ILE13
G	ALA14
G	ILE16
G	GLU17
G	ALA18
G	VAL19
G	ASP25
G	ARG29
G	LEU32
G	SER33
G	ASP34
G	ASN35
G	GLU36
G	ALA38
G	ILE39
G	TRP40
G	LYS41
H	GLU114
J	ILE11
J	GLY12
J	GLU13
J	GLN14
J	GLY16
J	VAL17
J	LEU32
J	ASP35
J	SER36
J	ASP38
J	THR39
J	VAL40
J	GLU41

---

site_id	AC7
Number of Residues	5
Details

Chain	Residue
G	ALA112
G	ASP113
I	GLU58
L	ASP35
L	LEU37

---

site_id	AC8
Number of Residues	4
Details

Chain	Residue
N	LYS62
O	ASP113
Q	ASP35
Q	LEU37

---

site_id	AC9
Number of Residues	5
Details

Chain	Residue
M	ALA112
M	ASP113
O	LYS62
R	ASP35
R	LEU37

---

site_id	AD1
Number of Residues	7
Details

Chain	Residue
S	GLU58
S	LYS62
T	LEU111
T	ALA112
T	ASP113
V	ASP35
V	LEU37

---

site_id	AD2
Number of Residues	8
Details

Chain	Residue
T	LYS62
U	LEU111
U	ALA112
U	ASP113
W	ASP35
W	LEU37
W	ASP38
W	VAL40

---

site_id	AD3
Number of Residues	9
Details

Chain	Residue
X	GLU57
X	GLU60
S	ASP113
U	GLU58
U	LYS62
X	ASP35
X	LEU37
X	ASP38
X	THR39

---

site_id	AD4
Number of Residues	9
Details

Chain	Residue
a	GLU58
b	ALA112
b	ASP113
d	VAL29
d	ASP35
d	LEU37
d	ASP38
d	THR39
d	GLU60

---

site_id	AD5
Number of Residues	7
Details

Chain	Residue
b	GLU58
b	LYS62
c	LEU111
c	ALA112
c	ASP113
e	ASP35
e	LEU37

---

site_id	AD6
Number of Residues	8
Details

Chain	Residue
a	ASP113
c	GLU58
c	LYS62
f	ASP35
f	LEU37
f	ASP38
f	GLU57
f	GLU60

---

Functional Information from PROSITE/UniProt

site_id	PS00012
Number of Residues	16
Details	PHOSPHOPANTETHEINE Phosphopantetheine attachment site. DLGADSLDTVELVMAL

Chain	Residue	Details
X	ASP31-LEU46

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	30
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00101","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1125
Details	Domain: {"description":"Carrier","evidences":[{"source":"PROSITE-ProRule","id":"PRU00258","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	15
Details	Modified residue: {"description":"O-(pantetheine 4'-phosphoryl)serine","evidences":[{"source":"PROSITE-ProRule","id":"PRU00258","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"4882207","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---