5VAH
Crystal structure of ATXR5 SET domain in complex with histone H3 di-methylated on R26
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | binding site for residue SAH A 401 |
| Chain | Residue |
| A | LEU187 |
| A | TYR361 |
| A | TYR368 |
| A | PHE373 |
| A | VAL374 |
| A | HOH514 |
| A | HOH540 |
| A | ARG249 |
| A | GLU250 |
| A | PHE252 |
| A | ASP285 |
| A | ARG312 |
| A | PHE313 |
| A | SER315 |
| A | GLY316 |
| site_id | AC2 |
| Number of Residues | 16 |
| Details | binding site for residue SAH B 401 |
| Chain | Residue |
| B | ARG249 |
| B | GLU250 |
| B | GLY251 |
| B | PHE252 |
| B | ASP285 |
| B | SER286 |
| B | ARG312 |
| B | PHE313 |
| B | SER315 |
| B | GLY316 |
| B | TYR361 |
| B | TYR368 |
| B | PHE373 |
| B | VAL374 |
| B | HOH507 |
| D | LYS27 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | SITE: Not N6-acetylated => ECO:0000269|PubMed:15598823 |
| Chain | Residue | Details |
| A | TYR364 | |
| B | MET216 | |
| B | GLU250 | |
| B | ARG312 | |
| B | ARG334 | |
| B | TYR364 | |
| C | LYS27 | |
| D | LYS27 | |
| A | ARG312 | |
| A | ARG334 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | SITE: Required for interaction with TSK => ECO:0000269|PubMed:35298257 |
| Chain | Residue | Details |
| B | TYR368 | |
| B | VAL374 | |
| C | ALA31 | |
| D | ALA31 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:15598823 |
| Chain | Residue | Details |
| C | LYS23 | |
| D | LYS23 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:14712277, ECO:0000269|PubMed:15598823, ECO:0000269|PubMed:17174094, ECO:0000269|PubMed:17439305, ECO:0000269|PubMed:19503079, ECO:0000269|PubMed:24626927, ECO:0000269|PubMed:35298257 |
| Chain | Residue | Details |
| C | LYS27 | |
| D | LYS27 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:14610360, ECO:0000269|PubMed:15753571 |
| Chain | Residue | Details |
| C | SER28 | |
| D | SER28 |
