5VAH
Crystal structure of ATXR5 SET domain in complex with histone H3 di-methylated on R26
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | binding site for residue SAH A 401 |
| Chain | Residue |
| A | LEU187 |
| A | TYR361 |
| A | TYR368 |
| A | PHE373 |
| A | VAL374 |
| A | HOH514 |
| A | HOH540 |
| A | ARG249 |
| A | GLU250 |
| A | PHE252 |
| A | ASP285 |
| A | ARG312 |
| A | PHE313 |
| A | SER315 |
| A | GLY316 |
| site_id | AC2 |
| Number of Residues | 16 |
| Details | binding site for residue SAH B 401 |
| Chain | Residue |
| B | ARG249 |
| B | GLU250 |
| B | GLY251 |
| B | PHE252 |
| B | ASP285 |
| B | SER286 |
| B | ARG312 |
| B | PHE313 |
| B | SER315 |
| B | GLY316 |
| B | TYR361 |
| B | TYR368 |
| B | PHE373 |
| B | VAL374 |
| B | HOH507 |
| D | LYS27 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 244 |
| Details | Domain: {"description":"SET","evidences":[{"source":"PROSITE-ProRule","id":"PRU00190","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 18 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00190","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"24626927","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Site: {"description":"Not N6-acetylated","evidences":[{"source":"PubMed","id":"15598823","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Site: {"description":"Required for interaction with TSK","evidences":[{"source":"PubMed","id":"35298257","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"15598823","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"14712277","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15598823","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17174094","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17439305","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19503079","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24626927","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35298257","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"14610360","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15753571","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
