Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5V6O

Crystal Structure of the highly open channel-stabilized mutant G-2'I + I9'A of GLIC

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0005216	molecular_function	monoatomic ion channel activity
A	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
A	0005267	molecular_function	potassium channel activity
A	0005272	molecular_function	sodium channel activity
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006814	biological_process	sodium ion transport
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0035725	biological_process	sodium ion transmembrane transport
A	0042802	molecular_function	identical protein binding
A	0071805	biological_process	potassium ion transmembrane transport
A	1902495	cellular_component	transmembrane transporter complex
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
B	0005267	molecular_function	potassium channel activity
B	0005272	molecular_function	sodium channel activity
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0006814	biological_process	sodium ion transport
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0035725	biological_process	sodium ion transmembrane transport
B	0042802	molecular_function	identical protein binding
B	0071805	biological_process	potassium ion transmembrane transport
B	1902495	cellular_component	transmembrane transporter complex
C	0004888	molecular_function	transmembrane signaling receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
C	0005267	molecular_function	potassium channel activity
C	0005272	molecular_function	sodium channel activity
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0006814	biological_process	sodium ion transport
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0035725	biological_process	sodium ion transmembrane transport
C	0042802	molecular_function	identical protein binding
C	0071805	biological_process	potassium ion transmembrane transport
C	1902495	cellular_component	transmembrane transporter complex
D	0004888	molecular_function	transmembrane signaling receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
D	0005267	molecular_function	potassium channel activity
D	0005272	molecular_function	sodium channel activity
D	0005886	cellular_component	plasma membrane
D	0006811	biological_process	monoatomic ion transport
D	0006814	biological_process	sodium ion transport
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0035725	biological_process	sodium ion transmembrane transport
D	0042802	molecular_function	identical protein binding
D	0071805	biological_process	potassium ion transmembrane transport
D	1902495	cellular_component	transmembrane transporter complex
E	0004888	molecular_function	transmembrane signaling receptor activity
E	0005216	molecular_function	monoatomic ion channel activity
E	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
E	0005267	molecular_function	potassium channel activity
E	0005272	molecular_function	sodium channel activity
E	0005886	cellular_component	plasma membrane
E	0006811	biological_process	monoatomic ion transport
E	0006814	biological_process	sodium ion transport
E	0016020	cellular_component	membrane
E	0034220	biological_process	monoatomic ion transmembrane transport
E	0035725	biological_process	sodium ion transmembrane transport
E	0042802	molecular_function	identical protein binding
E	0071805	biological_process	potassium ion transmembrane transport
E	1902495	cellular_component	transmembrane transporter complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue LMT A 401

Chain	Residue
A	ILE240
B	LMT402
D	LMT401
E	ALA234

site_id	AC2
Number of Residues	1
Details	binding site for residue CL A 402

Chain	Residue
A	TYR221

site_id	AC3
Number of Residues	1
Details	binding site for residue NA A 403

Chain	Residue
E	THR226

site_id	AC4
Number of Residues	1
Details	binding site for residue SO4 A 404

Chain	Residue
A	ARG109

site_id	AC5
Number of Residues	3
Details	binding site for residue SO4 B 401

Chain	Residue
B	ARG109
A	SER29
B	GLU82

site_id	AC6
Number of Residues	3
Details	binding site for residue LMT B 402

Chain	Residue
A	LMT401
B	ALA237
D	LMT401

site_id	AC7
Number of Residues	1
Details	binding site for residue CL B 403

Chain	Residue
B	TYR221

site_id	AC8
Number of Residues	3
Details	binding site for residue SO4 B 404

Chain	Residue
A	ARG296
B	TYR278
B	GLU282

site_id	AC9
Number of Residues	3
Details	binding site for residue SO4 B 405

Chain	Residue
B	ARG293
B	ARG296
C	TYR278

site_id	AD1
Number of Residues	5
Details	binding site for residue LMT D 401

Chain	Residue
A	LMT401
B	LMT402
C	LMT403
D	LMT402
E	LMT403

site_id	AD2
Number of Residues	7
Details	binding site for residue LMT D 402

Chain	Residue
C	ALA233
C	ALA234
D	ALA233
D	ALA237
D	ILE240
D	LMT401
E	LMT403

site_id	AD3
Number of Residues	1
Details	binding site for residue CL D 403

Chain	Residue
D	TYR221

site_id	AD4
Number of Residues	3
Details	binding site for residue SO4 D 404

Chain	Residue
D	ARG293
E	TYR278
E	GLU282

site_id	AD5
Number of Residues	4
Details	binding site for residue SO4 E 401

Chain	Residue
A	TYR278
A	GLU282
E	ARG293
E	ARG296

site_id	AD6
Number of Residues	2
Details	binding site for residue SO4 E 402

Chain	Residue
D	SER29
E	ARG109

site_id	AD7
Number of Residues	6
Details	binding site for residue LMT E 403

Chain	Residue
D	ALA233
D	ALA237
D	LMT401
D	LMT402
E	ALA233
E	ALA237

site_id	AD8
Number of Residues	1
Details	binding site for residue CL E 404

Chain	Residue
E	TYR221

site_id	AD9
Number of Residues	1
Details	binding site for residue SO4 C 401

Chain	Residue
C	ARG109

site_id	AE1
Number of Residues	4
Details	binding site for residue SO4 C 402

Chain	Residue
C	ARG293
C	ARG296
D	TYR278
D	GLU282

site_id	AE2
Number of Residues	1
Details	binding site for residue LMT C 403

Chain	Residue
D	LMT401

site_id	AE3
Number of Residues	1
Details	binding site for residue CL C 404

Chain	Residue
C	TYR221

site_id	AE4
Number of Residues	2
Details	binding site for residue SO4 C 405

Chain	Residue
C	SER29
D	ARG109

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	530
Details	TRANSMEM: Helical

Chain	Residue	Details
A	TYR194-PHE216
D	SER220-THR244
D	THR253-VAL281
D	PRO285-PHE317
E	TYR194-PHE216
E	SER220-THR244
E	THR253-VAL281
E	PRO285-PHE317
C	TYR194-PHE216
C	SER220-THR244
C	THR253-VAL281
A	SER220-THR244
C	PRO285-PHE317
A	THR253-VAL281
A	PRO285-PHE317
B	TYR194-PHE216
B	SER220-THR244
B	THR253-VAL281
B	PRO285-PHE317
D	TYR194-PHE216

site_id	SWS_FT_FI2
Number of Residues	20
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
A	TRP217-THR219
C	GLU282-GLN284
A	GLU282-GLN284
B	TRP217-THR219
B	GLU282-GLN284
D	TRP217-THR219
D	GLU282-GLN284
E	TRP217-THR219
E	GLU282-GLN284
C	TRP217-THR219

site_id	SWS_FT_FI3
Number of Residues	35
Details	TOPO_DOM: Periplasmic => ECO:0000255

Chain	Residue	Details
A	ASN245-MET252
B	ASN245-MET252
D	ASN245-MET252
E	ASN245-MET252
C	ASN245-MET252

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)