5V0D

Crystal structure of human exonuclease 1 Exo1 (WT) in complex with 5' flap DNA (f2II)

Functional Information from GO Data

Chain	GOid	namespace	contents
Z	0003677	molecular_function	DNA binding
Z	0003824	molecular_function	catalytic activity
Z	0004518	molecular_function	nuclease activity
Z	0016788	molecular_function	hydrolase activity, acting on ester bonds
Z	0035312	molecular_function	5'-3' DNA exonuclease activity
Z	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue MG Z 401

Chain	Residue
B	DG1
Z	ASP152
Z	ASP171
Z	ASP173
Z	HOH513

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site_id	AC2
Number of Residues	6
Details	binding site for residue MG Z 402

Chain	Residue
Z	HOH525
Z	HOH526
B	DG1
B	HOH102
E	DA2
Z	ASP152

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site_id	AC3
Number of Residues	6
Details	binding site for residue NA Z 403

Chain	Residue
A	DT4
A	HOH101
Z	SER222
Z	SER229
Z	ILE233
Z	HOH547

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Functional Information from PROSITE/UniProt

site_id	PS00841
Number of Residues	15
Details	XPG_1 XPG protein signature 1. IKPiLVFDGctLpSK

Chain	Residue	Details
Z	ILE71-LYS85

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site_id	PS00842
Number of Residues	15
Details	XPG_2 XPG protein signature 2. GVDCLvAPyEADAQL

Chain	Residue	Details
Z	GLY141-LEU155

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P39748

Chain	Residue	Details
Z	ASP30
Z	ASP225

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site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000250|UniProtKB:Q17RS7

Chain	Residue	Details
Z	ASP78
Z	GLU150

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site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0007744|PDB:3QEB, ECO:0007744|PDB:5V05, ECO:0007744|PDB:5V06, ECO:0007744|PDB:5V07, ECO:0007744|PDB:5V08, ECO:0007744|PDB:5V09, ECO:0007744|PDB:5V0A, ECO:0007744|PDB:5V0B, ECO:0007744|PDB:5V0D

Chain	Residue	Details
Z	ASP152
Z	ASP171

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site_id	SWS_FT_FI4
Number of Residues	1
Details	BINDING: BINDING => ECO:0007744|PDB:3QEB, ECO:0007744|PDB:5V05, ECO:0007744|PDB:5V06, ECO:0007744|PDB:5V09, ECO:0007744|PDB:5V0A, ECO:0007744|PDB:5V0B, ECO:0007744|PDB:5V0D

Chain	Residue	Details
Z	ASP173

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site_id	SWS_FT_FI5
Number of Residues	1
Details	BINDING: BINDING => ECO:0000250|UniProtKB:Q58839

Chain	Residue	Details
Z	ASP270

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