5V0A
Crystal structure of human exonuclease 1 Exo1 (D225A) in complex with 5' recessed-end DNA (rVIII)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| Z | 0003677 | molecular_function | DNA binding |
| Z | 0003824 | molecular_function | catalytic activity |
| Z | 0004518 | molecular_function | nuclease activity |
| Z | 0016788 | molecular_function | hydrolase activity, acting on ester bonds |
| Z | 0035312 | molecular_function | 5'-3' DNA exonuclease activity |
| Z | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue MN Z 401 |
| Chain | Residue |
| B | DC1 |
| Z | ASP152 |
| Z | ASP171 |
| Z | ASP173 |
| Z | HOH533 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue MN Z 402 |
| Chain | Residue |
| Z | HOH513 |
| Z | HOH521 |
| B | DC1 |
| B | D5M102 |
| Z | ASP152 |
| Z | HOH512 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue MN Z 403 |
| Chain | Residue |
| Z | CYS80 |
| Z | ILE325 |
| Z | HOH577 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue MN Z 404 |
| Chain | Residue |
| Z | GLU302 |
| Z | ASP303 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue NA Z 405 |
| Chain | Residue |
| A | DA5 |
| A | HOH204 |
| Z | SER222 |
| Z | SER229 |
| Z | ILE233 |
| Z | HOH524 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | binding site for residue MN A 101 |
| Chain | Residue |
| A | DC11 |
| Z | GLU44 |
| site_id | AC7 |
| Number of Residues | 1 |
| Details | binding site for residue MN B 101 |
| Chain | Residue |
| B | DG7 |
| site_id | AC8 |
| Number of Residues | 11 |
| Details | binding site for residue D5M B 102 |
| Chain | Residue |
| A | DT10 |
| B | DC1 |
| B | HOH201 |
| B | HOH203 |
| Z | HIS36 |
| Z | ARG92 |
| Z | ARG96 |
| Z | MN402 |
| Z | HOH513 |
| Z | HOH521 |
| Z | HOH557 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 91 |
| Details | Region: {"description":"I-domain"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P39748","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q17RS7","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"3QEB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V05","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V06","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V07","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V08","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V09","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V0A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V0B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V0D","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"3QEB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V05","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V06","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V09","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V0A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V0B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V0D","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q58839","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
