5UYY

Crystal structure of prephenate dehydrogenase tyrA from Bacillus anthracis in complex with L-tyrosine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004665	molecular_function	prephenate dehydrogenase (NADP+) activity
A	0006571	biological_process	L-tyrosine biosynthetic process
A	0008977	molecular_function	prephenate dehydrogenase (NAD+) activity
A	0009073	biological_process	aromatic amino acid family biosynthetic process
A	0016491	molecular_function	oxidoreductase activity
A	0046872	molecular_function	metal ion binding
A	0070403	molecular_function	NAD+ binding
B	0000166	molecular_function	nucleotide binding
B	0004665	molecular_function	prephenate dehydrogenase (NADP+) activity
B	0006571	biological_process	L-tyrosine biosynthetic process
B	0008977	molecular_function	prephenate dehydrogenase (NAD+) activity
B	0009073	biological_process	aromatic amino acid family biosynthetic process
B	0016491	molecular_function	oxidoreductase activity
B	0046872	molecular_function	metal ion binding
B	0070403	molecular_function	NAD+ binding
C	0000166	molecular_function	nucleotide binding
C	0004665	molecular_function	prephenate dehydrogenase (NADP+) activity
C	0006571	biological_process	L-tyrosine biosynthetic process
C	0008977	molecular_function	prephenate dehydrogenase (NAD+) activity
C	0009073	biological_process	aromatic amino acid family biosynthetic process
C	0016491	molecular_function	oxidoreductase activity
C	0046872	molecular_function	metal ion binding
C	0070403	molecular_function	NAD+ binding
D	0000166	molecular_function	nucleotide binding
D	0004665	molecular_function	prephenate dehydrogenase (NADP+) activity
D	0006571	biological_process	L-tyrosine biosynthetic process
D	0008977	molecular_function	prephenate dehydrogenase (NAD+) activity
D	0009073	biological_process	aromatic amino acid family biosynthetic process
D	0016491	molecular_function	oxidoreductase activity
D	0046872	molecular_function	metal ion binding
D	0070403	molecular_function	NAD+ binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	binding site for residue TYR A 401

Chain	Residue
A	LEU314
B	LYS139
B	SER333
B	ILE334
A	ASP315
A	LYS316
A	ALA319
A	LEU320
A	GLU341
A	GLY348
A	HOH519
A	HOH546

---

site_id	AC2
Number of Residues	11
Details	binding site for residue TYR B 401

Chain	Residue
A	ASN152
A	SER333
A	ILE334
B	LEU314
B	ASP315
B	LYS316
B	ALA319
B	LEU320
B	HOH501
B	HOH515
B	HOH524

---

site_id	AC3
Number of Residues	13
Details	binding site for residue TYR C 401

Chain	Residue
C	VAL313
C	LEU314
C	ASP315
C	LYS316
C	ALA319
C	LEU320
C	GLU341
C	GLY348
C	HOH520
C	HOH530
D	LYS139
D	SER333
D	ILE334

---

site_id	AC4
Number of Residues	14
Details	binding site for residue TYR D 401

Chain	Residue
C	ASN152
C	SER333
C	ILE334
D	VAL313
D	LEU314
D	ASP315
D	LYS316
D	GLY318
D	ALA319
D	LEU320
D	VAL349
D	HOH503
D	HOH535
D	HOH548

---