5UVW

BRD4_Bromodomain1-A1376855

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	binding site for residue 8NG A 201

Chain	Residue
A	TRP81
A	ASN140
A	ILE146
A	SO4202
A	HOH303
B	TRP81
B	8NG201
A	PRO82
A	PHE83
A	GLN85
A	PRO86
A	VAL87
A	ASP88
A	LYS91
A	LEU92

---

site_id	AC2
Number of Residues	6
Details	binding site for residue SO4 A 202

Chain	Residue
A	TRP81
A	LYS91
A	8NG201
B	TRP81
B	LYS91
B	8NG201

---

site_id	AC3
Number of Residues	15
Details	binding site for residue 8NG B 201

Chain	Residue
A	TRP81
A	8NG201
A	SO4202
B	TRP81
B	PRO82
B	GLN85
B	PRO86
B	VAL87
B	ASP88
B	LYS91
B	LEU92
B	LEU94
B	ASN140
B	ILE146
B	HOH302

---

site_id	AC4
Number of Residues	15
Details	binding site for residue 8NG C 201

Chain	Residue
C	TRP81
C	TRP81
C	PRO82
C	PHE83
C	GLN85
C	PRO86
C	VAL87
C	ASP88
C	LYS91
C	LEU92
C	ASN140
C	ILE146
C	SO4202
C	SO4202
C	HOH301

---

site_id	AC5
Number of Residues	6
Details	binding site for residue SO4 C 202

Chain	Residue
C	TRP81
C	TRP81
C	LYS91
C	LYS91
C	8NG201
C	8NG201

---

Functional Information from PROSITE/UniProt

site_id	PS00633
Number of Residues	60
Details	BROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY

Chain	Residue	Details
A	ALA80-TYR139

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	SITE: Acetylated histone binding => ECO:0000269|PubMed:22464331

Chain	Residue	Details
A	ASN140
B	ASN140
C	ASN140

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
A	LYS99
B	LYS99
C	LYS99

---