5UVG

Crystal structure of the human neutral sphingomyelinase 2 (nSMase2) catalytic domain with insertion deleted and calcium bound

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004767	molecular_function	sphingomyelin phosphodiesterase activity
A	0005576	cellular_component	extracellular region
A	0008081	molecular_function	phosphoric diester hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue CA A 701

Chain	Residue
A	GLU364
A	ASP429
A	ASP430
A	HOH869
A	HOH873
A	HOH897
A	HOH906

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000250

Chain	Residue	Details
A	HIS639

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site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	GLU364

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site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Important for substrate recognition => ECO:0000250

Chain	Residue	Details
A	ASN512

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9JJY3

Chain	Residue	Details
A	GLU343

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site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
A	TYR456

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site_id	SWS_FT_FI6
Number of Residues	2
Details	LIPID: S-palmitoyl cysteine => ECO:0000250

Chain	Residue	Details
A	CYS397
A	CYS398

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