5UPD

Methyltransferase domain of human Wolf-Hirschhorn Syndrome Candidate 1-Like protein 1 (WHSC1L1)

Replaces:  4YZ8

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005634	cellular_component	nucleus
A	0042054	molecular_function	histone methyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	19
Details	binding site for residue SAM A 1301

Chain	Residue
A	ARG1155
A	TYR1261
A	GLU1272
A	CYS1273
A	HIS1274
A	LEU1284
A	HOH1433
A	HOH1438
A	HOH1444
A	HOH1456
A	HOH1483
A	TRP1157
A	THR1197
A	ASN1198
A	PHE1199
A	TYR1200
A	ARG1220
A	ASN1223
A	HIS1224

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 1319

Chain	Residue
A	CYS1098
A	CYS1100
A	CYS1108
A	CYS1114

---

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN A 1320

Chain	Residue
A	CYS1108
A	CYS1123
A	CYS1128
A	CYS1134

---

site_id	AC4
Number of Residues	4
Details	binding site for residue ZN A 1321

Chain	Residue
A	CYS1226
A	CYS1273
A	CYS1275
A	CYS1280

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	50
Details	Domain: {"description":"AWS","evidences":[{"source":"PROSITE-ProRule","id":"PRU00562","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	117
Details	Domain: {"description":"SET","evidences":[{"source":"PROSITE-ProRule","id":"PRU00190","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	16
Details	Domain: {"description":"Post-SET","evidences":[{"source":"PROSITE-ProRule","id":"PRU00155","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"25218447","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---