5UP0
Crystal structure of human PDE1B catalytic domain in complex with inhibitor 3 (6-(4-chlorobenzyl)-8,9,10,11-tetrahydrobenzo[4,5]thieno[3,2-e][1,2,4]triazolo[1,5-c]pyrimidin-5(6H)-one)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| A | 0007165 | biological_process | signal transduction |
| A | 0008081 | molecular_function | phosphoric diester hydrolase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue ZN A 601 |
| Chain | Residue |
| A | HIS227 |
| A | HIS263 |
| A | ASP264 |
| A | ASP370 |
| A | HOH703 |
| A | HOH775 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 602 |
| Chain | Residue |
| A | HOH732 |
| A | HOH745 |
| A | HOH783 |
| A | ASP264 |
| A | HOH703 |
| A | HOH716 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue 8HP A 603 |
| Chain | Residue |
| A | HIS373 |
| A | LEU388 |
| A | MET389 |
| A | LEU409 |
| A | GLN421 |
| A | PHE424 |
Functional Information from PROSITE/UniProt
| site_id | PS00126 |
| Number of Residues | 12 |
| Details | PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDYeHtGttNsF |
| Chain | Residue | Details |
| A | HIS263-PHE274 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | GLY243 | |
| Chain | Residue | Details |
| A | CYS247 | |
| A | ALA283 | |
| A | ILE284 | |
| A | GLU390 | |
| Chain | Residue | Details |
| A | VAL486 | |
