5UNG

XFEL structure of human angiotensin II type 2 receptor (Orthorhombic form) in complex with compound 1 (N-benzyl-N-(2-ethyl-4-oxo-3-{[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl] methyl}-3,4-dihydroquinazolin-6-yl)thiophene-2-carboxamide)

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0004930	molecular_function	G protein-coupled receptor activity
B	0004945	molecular_function	angiotensin type II receptor activity
B	0005506	molecular_function	iron ion binding
B	0006954	biological_process	inflammatory response
B	0007186	biological_process	G protein-coupled receptor signaling pathway
B	0009055	molecular_function	electron transfer activity
B	0016020	cellular_component	membrane
B	0020037	molecular_function	heme binding
B	0022900	biological_process	electron transport chain
B	0042597	cellular_component	periplasmic space
B	0042981	biological_process	regulation of apoptotic process
B	0046872	molecular_function	metal ion binding
B	0097746	biological_process	blood vessel diameter maintenance

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	binding site for residue 8ES B 1201

Chain	Residue
B	TYR51
B	LYS215
B	TRP269
B	PHE272
B	ILE304
B	PHE308
B	TRP100
B	TYR103
B	LEU124
B	THR125
B	MET128
B	PHE129
B	THR178
B	ARG182

---

site_id	AC2
Number of Residues	6
Details	binding site for residue OLC B 1202

Chain	Residue
B	PRO48
B	TYR52
B	THR102
B	SER105
B	ALA228
B	THR229

---

Functional Information from PROSITE/UniProt

site_id	PS00237
Number of Residues	17
Details	G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASIfFITCMSVDRYQsV

Chain	Residue	Details
B	ALA130-VAL146

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	22
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	13
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"description":"axial binding residue"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	24
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"28379944","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29967536","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31899086","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32669569","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5UNF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UNG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UNH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XJM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6JOD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7C6A","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	51
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"28379944","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29967536","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31899086","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32669569","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5UNF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UNG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UNH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XJM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6JOD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7C6A","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	23
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"28379944","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29967536","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31899086","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32669569","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5UNF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UNG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UNH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XJM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6JOD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7C6A","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	45
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"28379944","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29967536","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31899086","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32669569","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5UNF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UNG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UNH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XJM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6JOD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7C6A","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	25
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"28379944","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29967536","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31899086","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32669569","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5UNF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UNG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UNH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XJM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6JOD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7C6A","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"28379944","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29967536","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31899086","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32669569","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5UNF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UNG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UNH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XJM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6JOD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7C6A","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	25
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"28379944","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29967536","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31899086","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32669569","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5UNF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UNG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UNH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XJM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6JOD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7C6A","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	23
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"28379944","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29967536","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31899086","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32669569","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5UNF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UNG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UNH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XJM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6JOD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7C6A","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	25
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"28379944","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29967536","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31899086","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32669569","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5UNF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UNG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UNH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XJM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6JOD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7C6A","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	9
Details	Region: {"description":"Helix VIII","evidences":[{"source":"PubMed","id":"28379944","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31899086","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6JOD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"29967536","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31899086","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"5XJM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6JOD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"29967536","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5XJM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---