5UKA

Salmonella typhimurium AhpC E49Q mutant

Replaces:  4XS8

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004601	molecular_function	peroxidase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006979	biological_process	response to oxidative stress
A	0008379	molecular_function	thioredoxin peroxidase activity
A	0016209	molecular_function	antioxidant activity
A	0016491	molecular_function	oxidoreductase activity
A	0042744	biological_process	hydrogen peroxide catabolic process
A	0045454	biological_process	cell redox homeostasis
A	0051920	molecular_function	peroxiredoxin activity
A	0098869	biological_process	cellular oxidant detoxification
A	0102039	molecular_function	NADH-dependent peroxiredoxin activity
B	0004601	molecular_function	peroxidase activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006979	biological_process	response to oxidative stress
B	0008379	molecular_function	thioredoxin peroxidase activity
B	0016209	molecular_function	antioxidant activity
B	0016491	molecular_function	oxidoreductase activity
B	0042744	biological_process	hydrogen peroxide catabolic process
B	0045454	biological_process	cell redox homeostasis
B	0051920	molecular_function	peroxiredoxin activity
B	0098869	biological_process	cellular oxidant detoxification
B	0102039	molecular_function	NADH-dependent peroxiredoxin activity
C	0004601	molecular_function	peroxidase activity
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006979	biological_process	response to oxidative stress
C	0008379	molecular_function	thioredoxin peroxidase activity
C	0016209	molecular_function	antioxidant activity
C	0016491	molecular_function	oxidoreductase activity
C	0042744	biological_process	hydrogen peroxide catabolic process
C	0045454	biological_process	cell redox homeostasis
C	0051920	molecular_function	peroxiredoxin activity
C	0098869	biological_process	cellular oxidant detoxification
C	0102039	molecular_function	NADH-dependent peroxiredoxin activity
D	0004601	molecular_function	peroxidase activity
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006979	biological_process	response to oxidative stress
D	0008379	molecular_function	thioredoxin peroxidase activity
D	0016209	molecular_function	antioxidant activity
D	0016491	molecular_function	oxidoreductase activity
D	0042744	biological_process	hydrogen peroxide catabolic process
D	0045454	biological_process	cell redox homeostasis
D	0051920	molecular_function	peroxiredoxin activity
D	0098869	biological_process	cellular oxidant detoxification
D	0102039	molecular_function	NADH-dependent peroxiredoxin activity
E	0004601	molecular_function	peroxidase activity
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006979	biological_process	response to oxidative stress
E	0008379	molecular_function	thioredoxin peroxidase activity
E	0016209	molecular_function	antioxidant activity
E	0016491	molecular_function	oxidoreductase activity
E	0042744	biological_process	hydrogen peroxide catabolic process
E	0045454	biological_process	cell redox homeostasis
E	0051920	molecular_function	peroxiredoxin activity
E	0098869	biological_process	cellular oxidant detoxification
E	0102039	molecular_function	NADH-dependent peroxiredoxin activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue CL A 201

Chain	Residue
A	SER1
A	LEU2
A	HOH331
A	HOH335
A	HOH425

---

site_id	AC2
Number of Residues	4
Details	binding site for residue K A 202

Chain	Residue
A	THR72
A	THR72
A	HOH313
A	HOH375

---

site_id	AC3
Number of Residues	5
Details	binding site for residue CL B 201

Chain	Residue
A	HOH425
B	SER1
B	LEU2
B	HOH346
B	HOH397

---

site_id	AC4
Number of Residues	5
Details	binding site for residue K B 202

Chain	Residue
B	THR72
B	HOH322
C	THR72
C	HOH417
C	HOH484

---

site_id	AC5
Number of Residues	3
Details	binding site for residue NA B 203

Chain	Residue
A	HOH319
B	ASP118
B	HOH363

---

site_id	AC6
Number of Residues	5
Details	binding site for residue CL C 201

Chain	Residue
C	SER1
C	LEU2
C	HOH462
C	HOH478
D	HOH415

---

site_id	AC7
Number of Residues	4
Details	binding site for residue CL D 201

Chain	Residue
C	HOH463
D	SER1
D	LEU2
D	HOH415

---

site_id	AC8
Number of Residues	6
Details	binding site for residue K D 202

Chain	Residue
D	THR72
D	HOH353
D	HOH372
E	THR72
E	HOH309
E	HOH324

---

site_id	AC9
Number of Residues	4
Details	binding site for residue CL E 201

Chain	Residue
E	SER1
E	LEU2
E	ILE133
E	HOH316

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	775
Details	Domain: {"description":"Thioredoxin","evidences":[{"source":"PROSITE-ProRule","id":"PRU00691","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	5
Details	Active site: {"description":"Cysteine sulfenic acid (-SOH) intermediate","evidences":[{"source":"PubMed","id":"18986167","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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