5UJ7

Structure of the active form of human Origin Recognition Complex ATPase motor module, complex subunitS 1, 4, 5

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005524	molecular_function	ATP binding
A	0016887	molecular_function	ATP hydrolysis activity
B	0005524	molecular_function	ATP binding
B	0016887	molecular_function	ATP hydrolysis activity
C	0000166	molecular_function	nucleotide binding
C	0000781	cellular_component	chromosome, telomeric region
C	0000808	cellular_component	origin recognition complex
C	0003677	molecular_function	DNA binding
C	0003688	molecular_function	DNA replication origin binding
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005664	cellular_component	nuclear origin of replication recognition complex
C	0005730	cellular_component	nucleolus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006260	biological_process	DNA replication
C	0006270	biological_process	DNA replication initiation
C	0040038	biological_process	polar body extrusion after meiotic divisions
C	0051258	biological_process	protein polymerization
D	0000166	molecular_function	nucleotide binding
D	0000781	cellular_component	chromosome, telomeric region
D	0000808	cellular_component	origin recognition complex
D	0003677	molecular_function	DNA binding
D	0003688	molecular_function	DNA replication origin binding
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005664	cellular_component	nuclear origin of replication recognition complex
D	0005730	cellular_component	nucleolus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006260	biological_process	DNA replication
D	0006270	biological_process	DNA replication initiation
D	0040038	biological_process	polar body extrusion after meiotic divisions
D	0051258	biological_process	protein polymerization
E	0000808	cellular_component	origin recognition complex
E	0005634	cellular_component	nucleus
E	0006260	biological_process	DNA replication
F	0000808	cellular_component	origin recognition complex
F	0005634	cellular_component	nucleus
F	0006260	biological_process	DNA replication

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	binding site for residue ATP A 900

Chain	Residue
A	VAL500
A	ASN654
A	TYR681
A	ILE689
A	ALA719
A	ARG720
A	LEU723
A	MG901
C	ARG209
A	GLU502
A	CYS506
A	PRO536
A	GLY539
A	LYS540
A	THR541
A	ALA542
A	GLU621

---

site_id	AC2
Number of Residues	4
Details	binding site for residue MG A 901

Chain	Residue
A	THR541
A	ASP620
A	GLU621
A	ATP900

---

site_id	AC3
Number of Residues	17
Details	binding site for residue ATP C 501

Chain	Residue
C	GLN31
C	ASN36
C	PHE38
C	VAL40
C	PRO68
C	ARG69
C	GLY70
C	SER71
C	GLY72
C	LYS73
C	THR74
C	MET75
C	LEU276
C	ARG277
C	HIS280
C	MG502
E	ARG143

---

site_id	AC4
Number of Residues	4
Details	binding site for residue MG C 502

Chain	Residue
C	THR74
C	ASP159
C	ATP501
E	ARG143

---

site_id	AC5
Number of Residues	15
Details	binding site for residue ATP E 301

Chain	Residue
E	LEU9
E	HIS38
E	THR39
E	ALA40
E	SER41
E	GLY42
E	LYS43
E	THR44
E	TYR45
E	ASP125
E	GLU159
E	TYR182
E	ILE190
E	LEU222
E	ARG226

---

site_id	AC6
Number of Residues	4
Details	binding site for residue K E 302

Chain	Residue
E	PHE22
E	GLU24
E	THR119
E	TYR121

---

site_id	AC7
Number of Residues	18
Details	binding site for residue ATP B 901

Chain	Residue
B	VAL500
B	GLU502
B	CYS506
B	PRO536
B	GLY537
B	THR538
B	GLY539
B	LYS540
B	THR541
B	ALA542
B	GLU621
B	ASN654
B	TYR681
B	ILE689
B	ARG720
B	LEU723
B	MG902
D	ARG209

---

site_id	AC8
Number of Residues	3
Details	binding site for residue MG B 902

Chain	Residue
B	THR541
B	ASP620
B	ATP901

---

site_id	AC9
Number of Residues	15
Details	binding site for residue ATP D 501

Chain	Residue
D	GLN31
D	PHE38
D	VAL40
D	PRO68
D	ARG69
D	GLY70
D	SER71
D	GLY72
D	LYS73
D	THR74
D	MET75
D	LEU276
D	ARG277
D	MG502
F	ARG143

---

site_id	AD1
Number of Residues	4
Details	binding site for residue MG D 502

Chain	Residue
D	ATP501
F	ARG143
D	THR74
D	ASP159

---

site_id	AD2
Number of Residues	15
Details	binding site for residue ATP F 301

Chain	Residue
F	HIS38
F	THR39
F	ALA40
F	SER41
F	GLY42
F	LYS43
F	THR44
F	TYR45
F	ASP125
F	LYS126
F	GLU159
F	TYR182
F	ILE190
F	LEU222
F	ARG226

---

site_id	AD3
Number of Residues	5
Details	binding site for residue K F 302

Chain	Residue
F	PHE22
F	GLU24
F	HIS27
F	PHE28
F	THR119

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"28112645","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5UJ7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	20
Details	Binding site: {"evidences":[{"source":"PubMed","id":"28112645","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5UJ7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5UJM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	28
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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