5UJ7
Structure of the active form of human Origin Recognition Complex ATPase motor module, complex subunitS 1, 4, 5
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005524 | molecular_function | ATP binding |
| A | 0016887 | molecular_function | ATP hydrolysis activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0016887 | molecular_function | ATP hydrolysis activity |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0000781 | cellular_component | chromosome, telomeric region |
| C | 0000808 | cellular_component | origin recognition complex |
| C | 0003677 | molecular_function | DNA binding |
| C | 0003688 | molecular_function | DNA replication origin binding |
| C | 0005515 | molecular_function | protein binding |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005634 | cellular_component | nucleus |
| C | 0005654 | cellular_component | nucleoplasm |
| C | 0005664 | cellular_component | nuclear origin of replication recognition complex |
| C | 0005730 | cellular_component | nucleolus |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006260 | biological_process | DNA replication |
| C | 0006270 | biological_process | DNA replication initiation |
| C | 0016887 | molecular_function | ATP hydrolysis activity |
| C | 0040038 | biological_process | polar body extrusion after meiotic divisions |
| C | 0051258 | biological_process | protein polymerization |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0000781 | cellular_component | chromosome, telomeric region |
| D | 0000808 | cellular_component | origin recognition complex |
| D | 0003677 | molecular_function | DNA binding |
| D | 0003688 | molecular_function | DNA replication origin binding |
| D | 0005515 | molecular_function | protein binding |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005634 | cellular_component | nucleus |
| D | 0005654 | cellular_component | nucleoplasm |
| D | 0005664 | cellular_component | nuclear origin of replication recognition complex |
| D | 0005730 | cellular_component | nucleolus |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006260 | biological_process | DNA replication |
| D | 0006270 | biological_process | DNA replication initiation |
| D | 0016887 | molecular_function | ATP hydrolysis activity |
| D | 0040038 | biological_process | polar body extrusion after meiotic divisions |
| D | 0051258 | biological_process | protein polymerization |
| E | 0000808 | cellular_component | origin recognition complex |
| E | 0005634 | cellular_component | nucleus |
| E | 0006260 | biological_process | DNA replication |
| F | 0000808 | cellular_component | origin recognition complex |
| F | 0005634 | cellular_component | nucleus |
| F | 0006260 | biological_process | DNA replication |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 17 |
| Details | binding site for residue ATP A 900 |
| Chain | Residue |
| A | VAL500 |
| A | ASN654 |
| A | TYR681 |
| A | ILE689 |
| A | ALA719 |
| A | ARG720 |
| A | LEU723 |
| A | MG901 |
| C | ARG209 |
| A | GLU502 |
| A | CYS506 |
| A | PRO536 |
| A | GLY539 |
| A | LYS540 |
| A | THR541 |
| A | ALA542 |
| A | GLU621 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue MG A 901 |
| Chain | Residue |
| A | THR541 |
| A | ASP620 |
| A | GLU621 |
| A | ATP900 |
| site_id | AC3 |
| Number of Residues | 17 |
| Details | binding site for residue ATP C 501 |
| Chain | Residue |
| C | GLN31 |
| C | ASN36 |
| C | PHE38 |
| C | VAL40 |
| C | PRO68 |
| C | ARG69 |
| C | GLY70 |
| C | SER71 |
| C | GLY72 |
| C | LYS73 |
| C | THR74 |
| C | MET75 |
| C | LEU276 |
| C | ARG277 |
| C | HIS280 |
| C | MG502 |
| E | ARG143 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue MG C 502 |
| Chain | Residue |
| C | THR74 |
| C | ASP159 |
| C | ATP501 |
| E | ARG143 |
| site_id | AC5 |
| Number of Residues | 15 |
| Details | binding site for residue ATP E 301 |
| Chain | Residue |
| E | LEU9 |
| E | HIS38 |
| E | THR39 |
| E | ALA40 |
| E | SER41 |
| E | GLY42 |
| E | LYS43 |
| E | THR44 |
| E | TYR45 |
| E | ASP125 |
| E | GLU159 |
| E | TYR182 |
| E | ILE190 |
| E | LEU222 |
| E | ARG226 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue K E 302 |
| Chain | Residue |
| E | PHE22 |
| E | GLU24 |
| E | THR119 |
| E | TYR121 |
| site_id | AC7 |
| Number of Residues | 18 |
| Details | binding site for residue ATP B 901 |
| Chain | Residue |
| B | VAL500 |
| B | GLU502 |
| B | CYS506 |
| B | PRO536 |
| B | GLY537 |
| B | THR538 |
| B | GLY539 |
| B | LYS540 |
| B | THR541 |
| B | ALA542 |
| B | GLU621 |
| B | ASN654 |
| B | TYR681 |
| B | ILE689 |
| B | ARG720 |
| B | LEU723 |
| B | MG902 |
| D | ARG209 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue MG B 902 |
| Chain | Residue |
| B | THR541 |
| B | ASP620 |
| B | ATP901 |
| site_id | AC9 |
| Number of Residues | 15 |
| Details | binding site for residue ATP D 501 |
| Chain | Residue |
| D | GLN31 |
| D | PHE38 |
| D | VAL40 |
| D | PRO68 |
| D | ARG69 |
| D | GLY70 |
| D | SER71 |
| D | GLY72 |
| D | LYS73 |
| D | THR74 |
| D | MET75 |
| D | LEU276 |
| D | ARG277 |
| D | MG502 |
| F | ARG143 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue MG D 502 |
| Chain | Residue |
| D | ATP501 |
| F | ARG143 |
| D | THR74 |
| D | ASP159 |
| site_id | AD2 |
| Number of Residues | 15 |
| Details | binding site for residue ATP F 301 |
| Chain | Residue |
| F | HIS38 |
| F | THR39 |
| F | ALA40 |
| F | SER41 |
| F | GLY42 |
| F | LYS43 |
| F | THR44 |
| F | TYR45 |
| F | ASP125 |
| F | LYS126 |
| F | GLU159 |
| F | TYR182 |
| F | ILE190 |
| F | LEU222 |
| F | ARG226 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue K F 302 |
| Chain | Residue |
| F | PHE22 |
| F | GLU24 |
| F | HIS27 |
| F | PHE28 |
| F | THR119 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255 |
| Chain | Residue | Details |
| E | GLY37 | |
| F | GLY37 | |
| A | ARG720 | |
| B | VAL500 | |
| B | ASN654 | |
| B | ARG720 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-methyllysine => ECO:0007744|PubMed:24129315 |
| Chain | Residue | Details |
| C | LYS7 | |
| D | LYS7 | |
| A | GLU621 | |
| B | GLY534 | |
| B | ASP620 | |
| B | GLU621 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER478 | |
| B | SER478 |
