5UGV
DapB from Mycobacterium tuberculosis
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006520 | biological_process | amino acid metabolic process |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0008839 | molecular_function | 4-hydroxy-tetrahydrodipicolinate reductase |
| A | 0009085 | biological_process | lysine biosynthetic process |
| A | 0009089 | biological_process | lysine biosynthetic process via diaminopimelate |
| A | 0009274 | cellular_component | peptidoglycan-based cell wall |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016597 | molecular_function | amino acid binding |
| A | 0016726 | molecular_function | oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor |
| A | 0016743 | molecular_function | carboxyl- or carbamoyltransferase activity |
| A | 0019877 | biological_process | diaminopimelate biosynthetic process |
| A | 0050661 | molecular_function | NADP binding |
| A | 0051287 | molecular_function | NAD binding |
| A | 0070402 | molecular_function | NADPH binding |
| A | 0070404 | molecular_function | NADH binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006520 | biological_process | amino acid metabolic process |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0008839 | molecular_function | 4-hydroxy-tetrahydrodipicolinate reductase |
| B | 0009085 | biological_process | lysine biosynthetic process |
| B | 0009089 | biological_process | lysine biosynthetic process via diaminopimelate |
| B | 0009274 | cellular_component | peptidoglycan-based cell wall |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016597 | molecular_function | amino acid binding |
| B | 0016726 | molecular_function | oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor |
| B | 0016743 | molecular_function | carboxyl- or carbamoyltransferase activity |
| B | 0019877 | biological_process | diaminopimelate biosynthetic process |
| B | 0050661 | molecular_function | NADP binding |
| B | 0051287 | molecular_function | NAD binding |
| B | 0070402 | molecular_function | NADPH binding |
| B | 0070404 | molecular_function | NADH binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | binding site for residue NAD A 301 |
| Chain | Residue |
| A | GLY7 |
| A | THR77 |
| A | HOH419 |
| A | LYS9 |
| A | GLY10 |
| A | LYS11 |
| A | VAL12 |
| A | ASP33 |
| A | ALA34 |
| A | PHE52 |
| A | THR53 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 302 |
| Chain | Residue |
| A | LYS136 |
| A | SER141 |
| A | GLY142 |
| A | THR143 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue PGE A 303 |
| Chain | Residue |
| A | GLU195 |
| A | LEU197 |
| A | THR206 |
| B | ARG208 |
| B | ASP210 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue PGE A 304 |
| Chain | Residue |
| A | LEU131 |
| A | LEU190 |
| A | GLU195 |
| A | ARG208 |
| B | GLU195 |
| B | THR206 |
| site_id | AC5 |
| Number of Residues | 21 |
| Details | binding site for residue NAD B 301 |
| Chain | Residue |
| A | GLU82 |
| A | GLN85 |
| B | GLY7 |
| B | LYS9 |
| B | GLY10 |
| B | LYS11 |
| B | VAL12 |
| B | ASP33 |
| B | ALA34 |
| B | PHE52 |
| B | THR53 |
| B | VAL57 |
| B | GLY75 |
| B | THR77 |
| B | ALA102 |
| B | PRO103 |
| B | ASN104 |
| B | PHE105 |
| B | HOH419 |
| B | HOH423 |
| B | HOH430 |
Functional Information from PROSITE/UniProt
| site_id | PS01298 |
| Number of Residues | 18 |
| Details | DAPB Dihydrodipicolinate reductase signature. EViElHhphKaDapSGTA |
| Chain | Residue | Details |
| A | GLU127-ALA144 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_00102","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00102","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12962488","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1C3V","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12962488","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1C3V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1P9L","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12962488","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20057050","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1P9L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YL7","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
