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5UFU

Structure of AMPK bound to activator

Functional Information from GO Data
ChainGOidnamespacecontents
A0000785cellular_componentchromatin
A0002842biological_processpositive regulation of T cell mediated immune response to tumor cell
A0003682molecular_functionchromatin binding
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0004676molecular_function3-phosphoinositide-dependent protein kinase activity
A0004677molecular_functionDNA-dependent protein kinase activity
A0004679molecular_functionAMP-activated protein kinase activity
A0004694molecular_functioneukaryotic translation initiation factor 2alpha kinase activity
A0004711molecular_functionribosomal protein S6 kinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006006biological_processglucose metabolic process
A0006325biological_processchromatin organization
A0006338biological_processchromatin remodeling
A0006468biological_processprotein phosphorylation
A0006633biological_processfatty acid biosynthetic process
A0006695biological_processcholesterol biosynthetic process
A0006914biological_processautophagy
A0008284biological_processpositive regulation of cell population proliferation
A0008610biological_processlipid biosynthetic process
A0009410biological_processresponse to xenobiotic stimulus
A0009411biological_processresponse to UV
A0009631biological_processcold acclimation
A0010332biological_processresponse to gamma radiation
A0010508biological_processpositive regulation of autophagy
A0010628biological_processpositive regulation of gene expression
A0010629biological_processnegative regulation of gene expression
A0014823biological_processresponse to activity
A0016055biological_processWnt signaling pathway
A0016324cellular_componentapical plasma membrane
A0016607cellular_componentnuclear speck
A0017148biological_processnegative regulation of translation
A0019395biological_processfatty acid oxidation
A0030424cellular_componentaxon
A0030425cellular_componentdendrite
A0031000biological_processresponse to caffeine
A0031588cellular_componentnucleotide-activated protein kinase complex
A0031669biological_processcellular response to nutrient levels
A0032007biological_processnegative regulation of TOR signaling
A0032991cellular_componentprotein-containing complex
A0033554biological_processcellular response to stress
A0034599biological_processcellular response to oxidative stress
A0035175molecular_functionhistone H3S10 kinase activity
A0035402molecular_functionhistone H3T11 kinase activity
A0035403molecular_functionhistone H3T6 kinase activity
A0035979molecular_functionhistone H2AXS139 kinase activity
A0042149biological_processcellular response to glucose starvation
A0042542biological_processresponse to hydrogen peroxide
A0042557molecular_functioneukaryotic elongation factor-2 kinase activator activity
A0042593biological_processglucose homeostasis
A0042752biological_processregulation of circadian rhythm
A0043025cellular_componentneuronal cell body
A0043066biological_processnegative regulation of apoptotic process
A0043627biological_processresponse to estrogen
A0044022molecular_functionhistone H3S28 kinase activity
A0044023molecular_functionhistone H4S1 kinase activity
A0044024molecular_functionhistone H2AS1 kinase activity
A0044025molecular_functionhistone H2BS14 kinase activity
A0044877molecular_functionprotein-containing complex binding
A0045722biological_processpositive regulation of gluconeogenesis
A0045821biological_processpositive regulation of glycolytic process
A0045893biological_processpositive regulation of DNA-templated transcription
A0046321biological_processpositive regulation of fatty acid oxidation
A0046326biological_processpositive regulation of D-glucose import
A0046627biological_processnegative regulation of insulin receptor signaling pathway
A0046872molecular_functionmetal ion binding
A0047322molecular_function[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
A0048511biological_processrhythmic process
A0048643biological_processpositive regulation of skeletal muscle tissue development
A0050321molecular_functiontau-protein kinase activity
A0050870biological_processpositive regulation of T cell activation
A0050995biological_processnegative regulation of lipid catabolic process
A0055089biological_processfatty acid homeostasis
A0060627biological_processregulation of vesicle-mediated transport
A0061744biological_processmotor behavior
A0061762biological_processCAMKK-AMPK signaling cascade
A0062028biological_processregulation of stress granule assembly
A0070050biological_processneuron cellular homeostasis
A0070301biological_processcellular response to hydrogen peroxide
A0070507biological_processregulation of microtubule cytoskeleton organization
A0071277biological_processcellular response to calcium ion
A0071333biological_processcellular response to glucose stimulus
A0071361biological_processcellular response to ethanol
A0071380biological_processcellular response to prostaglandin E stimulus
A0071456biological_processcellular response to hypoxia
A0071466biological_processcellular response to xenobiotic stimulus
A0072354molecular_functionhistone H3T3 kinase activity
A0072371molecular_functionhistone H2AS121 kinase activity
A0072518molecular_functionRho-dependent protein serine/threonine kinase activity
A0097009biological_processenergy homeostasis
A0106310molecular_functionprotein serine kinase activity
A0140823molecular_functionhistone H2BS36 kinase activity
A0140855molecular_functionhistone H3S57 kinase activity
A0140857molecular_functionhistone H3T45 kinase activity
A1903109biological_processpositive regulation of mitochondrial transcription
A1903829biological_processpositive regulation of protein localization
A1903944biological_processnegative regulation of hepatocyte apoptotic process
A1903955biological_processpositive regulation of protein targeting to mitochondrion
A1904179biological_processpositive regulation of adipose tissue development
A1904262biological_processnegative regulation of TORC1 signaling
A1904428biological_processnegative regulation of tubulin deacetylation
A1905691biological_processlipid droplet disassembly
A1990044biological_processprotein localization to lipid droplet
A1990244molecular_functionhistone H2AT120 kinase activity
A2000758biological_processpositive regulation of peptidyl-lysine acetylation
C0004672molecular_functionprotein kinase activity
C0004679molecular_functionAMP-activated protein kinase activity
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006110biological_processregulation of glycolytic process
C0006633biological_processfatty acid biosynthetic process
C0010628biological_processpositive regulation of gene expression
C0016208molecular_functionAMP binding
C0019887molecular_functionprotein kinase regulator activity
C0019901molecular_functionprotein kinase binding
C0031588cellular_componentnucleotide-activated protein kinase complex
C0031669biological_processcellular response to nutrient levels
C0032991cellular_componentprotein-containing complex
C0042149biological_processcellular response to glucose starvation
C0043531molecular_functionADP binding
C0043609biological_processregulation of carbon utilization
C0044877molecular_functionprotein-containing complex binding
C0045722biological_processpositive regulation of gluconeogenesis
C0051170biological_processimport into nucleus
Functional Information from PDB Data
site_idAC1
Number of Residues16
Detailsbinding site for residue STU A 601
ChainResidue
ALEU22
AVAL96
AGLY99
AGLU100
AGLU143
AASN144
ALEU146
AASP157
AGLY23
AVAL24
AGLY25
AALA43
AILE77
AMET93
AGLU94
ATYR95

site_idAC2
Number of Residues16
Detailsbinding site for residue 85V A 602
ChainResidue
AVAL11
ALEU18
AGLY19
APHE27
ALYS29
ALYS31
AILE46
AASN48
ALYS51
AASP88
AASP217
BARG83
BTHR106
BASP108
BVAL113
BILE115

site_idAC3
Number of Residues2
Detailsbinding site for residue CL A 603
ChainResidue
ASER97
AALA149

site_idAC4
Number of Residues1
Detailsbinding site for residue CL A 604
ChainResidue
AVAL24

site_idAC5
Number of Residues2
Detailsbinding site for residue SO4 A 606
ChainResidue
ALYS34
ALYS41

site_idAC6
Number of Residues11
Detailsbinding site for residue AMP C 401
ChainResidue
CHIS150
CTHR199
CILE203
CALA204
CVAL224
CSER225
CALA226
CILE311
CSER313
CSER315
CASP316

site_idAC7
Number of Residues11
Detailsbinding site for residue AMP C 402
ChainResidue
CARG69
CILE239
CSER241
CPHE243
CASP244
CARG268
CGLY274
CLEU276
CVAL296
CHIS297
CARG298

site_idAC8
Number of Residues12
Detailsbinding site for residue ADP C 403
ChainResidue
CARG69
CMET84
CTHR86
CTHR88
CASP89
CTYR120
CPRO127
CLEU128
CVAL129
CILE149
CHIS150
CARG151

site_idAC9
Number of Residues3
Detailsbinding site for residue SO4 C 404
ChainResidue
CARG151
CTHR167
CHIS297

Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues24
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGVGTFGKVKvGkheltghk..........VAVK
ChainResidueDetails
ALEU22-LYS45

site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VvHrDLKpeNVLL
ChainResidueDetails
AVAL135-LEU147

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsBINDING: BINDING => ECO:0000269|PubMed:17851531, ECO:0007744|PDB:2V92
ChainResidueDetails
CARG69
CMET84
CVAL129
CARG151
CLYS169
CSER241
CARG268
CLEU276

site_idSWS_FT_FI2
Number of Residues6
DetailsBINDING: BINDING => ECO:0000269|PubMed:17851531, ECO:0000269|PubMed:21399626, ECO:0007744|PDB:2V8Q, ECO:0007744|PDB:2Y8L
ChainResidueDetails
CHIS150
CTHR199
CALA204
CSER225
CHIS297
CSER313

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine; by ULK1 => ECO:0000305|PubMed:21460634
ChainResidueDetails
CSER260
ATHR344
ATHR371

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphothreonine; by ULK1 => ECO:0000305|PubMed:21460634
ChainResidueDetails
CTHR262

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphoserine; by ULK1 => ECO:0000269|PubMed:21460634
ChainResidueDetails
CSER269

site_idSWS_FT_FI6
Number of Residues5
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q13131
ChainResidueDetails
ASER345
ASER456
ALYS544

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: Phosphoserine; by ULK1 => ECO:0000305|PubMed:21460634
ChainResidueDetails
ASER349

site_idSWS_FT_FI8
Number of Residues2
DetailsMOD_RES: Phosphothreonine; by ULK1 => ECO:0000305|PubMed:21460634
ChainResidueDetails
ATHR357
ASER524

site_idSWS_FT_FI9
Number of Residues1
DetailsMOD_RES: Phosphoserine; by ULK1 => ECO:0000269|PubMed:21460634
ChainResidueDetails
ASER386

site_idSWS_FT_FI10
Number of Residues1
DetailsMOD_RES: Phosphoserine; by ULK1 => ECO:0000305|PubMed:21460634, ECO:0007744|PubMed:22673903
ChainResidueDetails
AGLY522

site_idSWS_FT_FI11
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:22673903
ChainResidueDetails
APRO526

site_idSWS_FT_FI12
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:12764152, ECO:0007744|PubMed:22673903
ChainResidueDetails
ATHR532

227344

PDB entries from 2024-11-13

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