5UDH
HHARI/ARIH1-UBCH7~Ubiquitin
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004842 | molecular_function | ubiquitin-protein transferase activity |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0016567 | biological_process | protein ubiquitination |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0004842 | molecular_function | ubiquitin-protein transferase activity |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0016567 | biological_process | protein ubiquitination |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0000151 | cellular_component | ubiquitin ligase complex |
| C | 0000209 | biological_process | protein polyubiquitination |
| C | 0003713 | molecular_function | transcription coactivator activity |
| C | 0003723 | molecular_function | RNA binding |
| C | 0004842 | molecular_function | ubiquitin-protein transferase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005634 | cellular_component | nucleus |
| C | 0005654 | cellular_component | nucleoplasm |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006355 | biological_process | regulation of DNA-templated transcription |
| C | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
| C | 0008283 | biological_process | cell population proliferation |
| C | 0016567 | biological_process | protein ubiquitination |
| C | 0016740 | molecular_function | transferase activity |
| C | 0019787 | molecular_function | ubiquitin-like protein transferase activity |
| C | 0019899 | molecular_function | enzyme binding |
| C | 0031398 | biological_process | positive regulation of protein ubiquitination |
| C | 0031625 | molecular_function | ubiquitin protein ligase binding |
| C | 0032446 | biological_process | protein modification by small protein conjugation |
| C | 0036211 | biological_process | protein modification process |
| C | 0044770 | biological_process | cell cycle phase transition |
| C | 0045893 | biological_process | positive regulation of DNA-templated transcription |
| C | 0051443 | biological_process | positive regulation of ubiquitin-protein transferase activity |
| C | 0061631 | molecular_function | ubiquitin conjugating enzyme activity |
| C | 0070979 | biological_process | protein K11-linked ubiquitination |
| C | 0071383 | biological_process | cellular response to steroid hormone stimulus |
| C | 0071385 | biological_process | cellular response to glucocorticoid stimulus |
| C | 0097027 | molecular_function | ubiquitin-protein transferase activator activity |
| C | 0098793 | cellular_component | presynapse |
| C | 1903955 | biological_process | positive regulation of protein targeting to mitochondrion |
| D | 0000151 | cellular_component | ubiquitin ligase complex |
| D | 0000209 | biological_process | protein polyubiquitination |
| D | 0003713 | molecular_function | transcription coactivator activity |
| D | 0003723 | molecular_function | RNA binding |
| D | 0004842 | molecular_function | ubiquitin-protein transferase activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005634 | cellular_component | nucleus |
| D | 0005654 | cellular_component | nucleoplasm |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006355 | biological_process | regulation of DNA-templated transcription |
| D | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
| D | 0008283 | biological_process | cell population proliferation |
| D | 0016567 | biological_process | protein ubiquitination |
| D | 0016740 | molecular_function | transferase activity |
| D | 0019787 | molecular_function | ubiquitin-like protein transferase activity |
| D | 0019899 | molecular_function | enzyme binding |
| D | 0031398 | biological_process | positive regulation of protein ubiquitination |
| D | 0031625 | molecular_function | ubiquitin protein ligase binding |
| D | 0032446 | biological_process | protein modification by small protein conjugation |
| D | 0036211 | biological_process | protein modification process |
| D | 0044770 | biological_process | cell cycle phase transition |
| D | 0045893 | biological_process | positive regulation of DNA-templated transcription |
| D | 0051443 | biological_process | positive regulation of ubiquitin-protein transferase activity |
| D | 0061631 | molecular_function | ubiquitin conjugating enzyme activity |
| D | 0070979 | biological_process | protein K11-linked ubiquitination |
| D | 0071383 | biological_process | cellular response to steroid hormone stimulus |
| D | 0071385 | biological_process | cellular response to glucocorticoid stimulus |
| D | 0097027 | molecular_function | ubiquitin-protein transferase activator activity |
| D | 0098793 | cellular_component | presynapse |
| D | 1903955 | biological_process | positive regulation of protein targeting to mitochondrion |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 601 |
| Chain | Residue |
| A | CYS344 |
| A | CYS347 |
| A | CYS362 |
| A | CYS367 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 602 |
| Chain | Residue |
| A | CYS372 |
| A | CYS375 |
| A | HIS382 |
| A | CYS389 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 603 |
| Chain | Residue |
| A | CYS281 |
| A | CYS297 |
| A | CYS299 |
| A | CYS276 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 604 |
| Chain | Residue |
| A | CYS304 |
| A | CYS307 |
| A | HIS312 |
| A | CYS317 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 605 |
| Chain | Residue |
| A | CYS186 |
| A | CYS189 |
| A | CYS208 |
| A | CYS211 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue ZN A 606 |
| Chain | Residue |
| A | CYS203 |
| A | HIS205 |
| A | CYS231 |
| A | ALA233 |
| A | CYS236 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 601 |
| Chain | Residue |
| B | CYS344 |
| B | CYS347 |
| B | CYS362 |
| B | CYS367 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 602 |
| Chain | Residue |
| B | CYS372 |
| B | CYS375 |
| B | HIS382 |
| B | CYS389 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 603 |
| Chain | Residue |
| B | CYS276 |
| B | CYS281 |
| B | CYS297 |
| B | CYS299 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 604 |
| Chain | Residue |
| B | CYS304 |
| B | CYS307 |
| B | HIS312 |
| B | CYS317 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 605 |
| Chain | Residue |
| B | CYS186 |
| B | CYS189 |
| B | CYS208 |
| B | CYS211 |
| site_id | AD3 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 606 |
| Chain | Residue |
| B | CYS203 |
| B | HIS205 |
| B | CYS231 |
| B | CYS236 |
Functional Information from PROSITE/UniProt
| site_id | PS00299 |
| Number of Residues | 26 |
| Details | UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD |
| Chain | Residue | Details |
| E | LYS27-ASP52 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Glycyl thioester intermediate => ECO:0000255|PROSITE-ProRule:PRU00388, ECO:0000255|PROSITE-ProRule:PRU10133 |
| Chain | Residue | Details |
| C | LYS86 | |
| D | LYS86 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| C | LYS131 | |
| D | LYS131 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 62 |
| Details | ZN_FING: RING-type 2; atypical => ECO:0000255|PROSITE-ProRule:PRU01221 |
| Chain | Residue | Details |
| A | CYS344-CYS375 | |
| B | CYS344-CYS375 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU01221, ECO:0000269|PubMed:21532592, ECO:0000269|PubMed:23707686 |
| Chain | Residue | Details |
| A | CYS357 | |
| B | CYS357 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 32 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01221, ECO:0000269|PubMed:23707686, ECO:0007744|PDB:4KBL, ECO:0007744|PDB:4KC9 |
| Chain | Residue | Details |
| A | CYS186 | |
| A | CYS281 | |
| A | CYS297 | |
| A | CYS299 | |
| A | CYS304 | |
| A | CYS307 | |
| A | HIS312 | |
| A | CYS317 | |
| B | CYS186 | |
| B | CYS189 | |
| B | CYS203 | |
| A | CYS189 | |
| B | HIS205 | |
| B | CYS208 | |
| B | CYS211 | |
| B | CYS231 | |
| B | CYS236 | |
| B | CYS276 | |
| B | CYS281 | |
| B | CYS297 | |
| B | CYS299 | |
| B | CYS304 | |
| A | CYS203 | |
| B | CYS307 | |
| B | HIS312 | |
| B | CYS317 | |
| A | HIS205 | |
| A | CYS208 | |
| A | CYS211 | |
| A | CYS231 | |
| A | CYS236 | |
| A | CYS276 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01221, ECO:0000269|PubMed:15236971, ECO:0000269|PubMed:23707686, ECO:0000269|PubMed:24058416, ECO:0007744|PDB:1WD2, ECO:0007744|PDB:2M9Y, ECO:0007744|PDB:4KBL, ECO:0007744|PDB:4KC9 |
| Chain | Residue | Details |
| A | CYS344 | |
| A | CYS347 | |
| A | CYS362 | |
| A | CYS367 | |
| B | CYS344 | |
| B | CYS347 | |
| B | CYS362 | |
| B | CYS367 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01221, ECO:0000269|PubMed:23707686, ECO:0000269|PubMed:24058416, ECO:0007744|PDB:2M9Y, ECO:0007744|PDB:4KBL, ECO:0007744|PDB:4KC9 |
| Chain | Residue | Details |
| A | CYS372 | |
| A | CYS375 | |
| A | HIS382 | |
| A | CYS389 | |
| B | CYS372 | |
| B | CYS375 | |
| B | HIS382 | |
| B | CYS389 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q9Z1K5 |
| Chain | Residue | Details |
| A | LYS142 | |
| B | LYS142 |
