5UAR

Dephosphorylated, ATP-free cystic fibrosis transmembrane conductance regulator (CFTR) from zebrafish

Replaces:  5TSI

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0002679	biological_process	respiratory burst involved in defense response
A	0005254	molecular_function	chloride channel activity
A	0005260	molecular_function	intracellularly ATP-gated chloride channel activity
A	0005524	molecular_function	ATP binding
A	0005768	cellular_component	endosome
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006821	biological_process	chloride transport
A	0006833	biological_process	water transport
A	0007507	biological_process	heart development
A	0008354	biological_process	germ cell migration
A	0015106	molecular_function	bicarbonate transmembrane transporter activity
A	0015701	biological_process	bicarbonate transport
A	0016020	cellular_component	membrane
A	0016323	cellular_component	basolateral plasma membrane
A	0016324	cellular_component	apical plasma membrane
A	0016853	molecular_function	isomerase activity
A	0016887	molecular_function	ATP hydrolysis activity
A	0030217	biological_process	T cell differentiation
A	0031016	biological_process	pancreas development
A	0031901	cellular_component	early endosome membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0034707	cellular_component	chloride channel complex
A	0035162	biological_process	embryonic hemopoiesis
A	0035377	biological_process	transepithelial water transport
A	0042742	biological_process	defense response to bacterium
A	0045087	biological_process	innate immune response
A	0050891	biological_process	multicellular organismal-level water homeostasis
A	0055038	cellular_component	recycling endosome membrane
A	0055085	biological_process	transmembrane transport
A	0060063	biological_process	Spemann organizer formation at the embryonic shield
A	0070121	biological_process	Kupffer's vesicle development
A	0090022	biological_process	regulation of neutrophil chemotaxis
A	0097535	biological_process	lymphoid lineage cell migration into thymus
A	0098660	biological_process	inorganic ion transmembrane transport
A	0140359	molecular_function	ABC-type transporter activity
A	1902476	biological_process	chloride transmembrane transport
A	1904322	biological_process	cellular response to forskolin

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	binding site for residue D10 A 1502

Chain	Residue
A	ARG1038

---

Functional Information from PROSITE/UniProt

site_id	PS00211
Number of Residues	15
Details	ABC_TRANSPORTER_1 ABC transporters family signature. LSGGQKARVALARAV

Chain	Residue	Details
A	LEU547-VAL561

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	284
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"27912062","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"27912062","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	63
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"27912062","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	25
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"27912062","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"27912062","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"27912062","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"27912062","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	22
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"27912062","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"27912062","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	21
Details	Transmembrane: {"description":"Discontinuously helical; Name=8","evidences":[{"source":"PubMed","id":"27912062","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	22
Details	Transmembrane: {"description":"Helical; Name=9","evidences":[{"source":"PubMed","id":"27912062","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=10","evidences":[{"source":"PubMed","id":"27912062","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=11","evidences":[{"source":"PubMed","id":"27912062","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=12","evidences":[{"source":"PubMed","id":"27912062","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	270
Details	Domain: {"description":"ABC transmembrane type-1 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00441","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P13569","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00434","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---