5U81
Acid ceramidase (ASAH1, aCDase) from naked mole rat, Cys143Ala, uncleaved
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005764 | cellular_component | lysosome |
| A | 0006631 | biological_process | fatty acid metabolic process |
| A | 0006665 | biological_process | sphingolipid metabolic process |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0017040 | molecular_function | N-acylsphingosine amidohydrolase activity |
| A | 0017064 | molecular_function | fatty acid amide hydrolase activity |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Nucleophile => ECO:0000269|PubMed:29692406 |
| Chain | Residue | Details |
| A | ALA143 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | SITE: Important for catalytic activity => ECO:0000250|UniProtKB:Q13510 |
| Chain | Residue | Details |
| A | ASP162 | |
| A | ASN320 | |
| A | ARG333 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:29692406, ECO:0007744|PDB:5U81 |
| Chain | Residue | Details |
| A | ASN173 | |
| A | ASN259 | |
| A | ASN286 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | SER348 |
