5U7D

PDE2 catalytic domain complexed with inhibitors

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
A	0007165	biological_process	signal transduction
A	0008081	molecular_function	phosphoric diester hydrolase activity
B	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
B	0007165	biological_process	signal transduction
B	0008081	molecular_function	phosphoric diester hydrolase activity
C	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
C	0007165	biological_process	signal transduction
C	0008081	molecular_function	phosphoric diester hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	19
Details	binding site for residue 19F A 1001

Chain	Residue
A	HIS656
A	LEU858
A	GLN859
A	PHE862
A	ILE866
A	ILE870
A	HOH1206
A	HOH1224
A	HOH1239
A	HOH1316
B	HIS587
A	THR768
A	LEU770
A	HIS773
A	THR805
A	LEU809
A	GLN812
A	ILE826
A	TYR827

---

site_id	AC2
Number of Residues	6
Details	binding site for residue ZN A 1002

Chain	Residue
A	HIS660
A	HIS696
A	ASP697
A	ASP808
A	HOH1102
A	HOH1159

---

site_id	AC3
Number of Residues	6
Details	binding site for residue MG A 1003

Chain	Residue
A	ASP697
A	HOH1102
A	HOH1105
A	HOH1136
A	HOH1222
A	HOH1318

---

site_id	AC4
Number of Residues	17
Details	binding site for residue 19F B 1001

Chain	Residue
B	HIS656
B	THR768
B	LEU770
B	THR805
B	LEU809
B	GLN812
B	ILE826
B	TYR827
B	MET847
B	LEU858
B	GLN859
B	PHE862
B	ILE866
B	ILE870
B	HOH1199
B	HOH1224
B	HOH1276

---

site_id	AC5
Number of Residues	6
Details	binding site for residue ZN B 1002

Chain	Residue
B	HIS660
B	HIS696
B	ASP697
B	ASP808
B	HOH1101
B	HOH1228

---

site_id	AC6
Number of Residues	6
Details	binding site for residue MG B 1003

Chain	Residue
B	ASP697
B	HOH1101
B	HOH1138
B	HOH1155
B	HOH1226
B	HOH1300

---

site_id	AC7
Number of Residues	21
Details	binding site for residue 19F C 1001

Chain	Residue
C	TYR655
C	HIS656
C	THR768
C	LEU770
C	HIS773
C	LEU809
C	GLN812
C	ILE826
C	TYR827
C	PHE830
C	MET847
C	LEU858
C	GLN859
C	SER861
C	PHE862
C	ILE866
C	ILE870
C	HOH1230
C	HOH1251
C	HOH1277
C	HOH1339

---

site_id	AC8
Number of Residues	6
Details	binding site for residue ZN C 1002

Chain	Residue
C	HIS660
C	HIS696
C	ASP697
C	ASP808
C	HOH1101
C	HOH1207

---

site_id	AC9
Number of Residues	6
Details	binding site for residue MG C 1003

Chain	Residue
C	ASP697
C	HOH1101
C	HOH1112
C	HOH1165
C	HOH1226
C	HOH1308

---

Functional Information from PROSITE/UniProt

site_id	PS00126
Number of Residues	12
Details	PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDLdHrGtnNsF

Chain	Residue	Details
A	HIS696-PHE707

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	Active site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"O76083","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15938621","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19828435","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23899287","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1Z1L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3IBJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ITM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ITU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4HTX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4HTZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JIB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15938621","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19828435","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23899287","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1Z1L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ITM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ITU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4HTX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4HTZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JIB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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