5U70
Chicken Slo2.2 in an open conformation vitrified in the presence of 300 mM NaCl
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005228 | molecular_function | intracellular sodium-activated potassium channel activity |
| A | 0005267 | molecular_function | potassium channel activity |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006813 | biological_process | potassium ion transport |
| A | 0015271 | molecular_function | outward rectifier potassium channel activity |
| A | 0016020 | cellular_component | membrane |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051289 | biological_process | protein homotetramerization |
| A | 0071805 | biological_process | potassium ion transmembrane transport |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 992 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| A | MET1-LEU92 | |
| A | LEU176-GLU184 | |
| A | ASN230-GLN249 | |
| A | GLU327-LEU1201 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=Segment S1 => ECO:0000269|PubMed:28111072, ECO:0007744|PDB:5U70 |
| Chain | Residue | Details |
| A | ARG93-LEU115 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 54 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| A | ASP116-LYS152 | |
| A | TRP207-PRO216 | |
| A | ARG273-SER279 | |
| A | PRO301-TRP304 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=Segment S2 => ECO:0000269|PubMed:28111072, ECO:0007744|PDB:5U70 |
| Chain | Residue | Details |
| A | LEU153-TYR175 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=Segment S3 => ECO:0000269|PubMed:28111072, ECO:0007744|PDB:5U70 |
| Chain | Residue | Details |
| A | GLN185-PHE206 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 12 |
| Details | TRANSMEM: Helical; Name=Segment S4 => ECO:0000269|PubMed:28111072, ECO:0007744|PDB:5U70 |
| Chain | Residue | Details |
| A | VAL217-GLU229 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=Segment S5 => ECO:0000269|PubMed:28111072, ECO:0007744|PDB:5U70 |
| Chain | Residue | Details |
| A | VAL250-GLU272 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 20 |
| Details | INTRAMEM: Pore-forming |
| Chain | Residue | Details |
| A | LEU280-THR300 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=Segment S6 => ECO:0000269|PubMed:28111072, ECO:0007744|PDB:5U70 |
| Chain | Residue | Details |
| A | PRO305-GLU326 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 21 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q5JUK3 |
| Chain | Residue | Details |
| A | VAL294 | |
| A | LYS756 | |
| A | CYS758 | |
| A | HIS760 | |
| A | ASN761 | |
| A | TYR769 | |
| A | GLY770 | |
| A | PHE771 | |
| A | SER779 | |
| A | LEU810 | |
| A | ASP812 | |
| A | GLY295 | |
| A | GLY834 | |
| A | ASP857 | |
| A | LEU511 | |
| A | HIS514 | |
| A | SER536 | |
| A | ASN538 | |
| A | CYS750 | |
| A | CYS751 | |
| A | ARG753 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN131 | |
| A | ASN136 |
