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5U6Y

Pseudo-atomic model of the CaMKIIa holoenzyme.

Functional Information from GO Data
ChainGOidnamespacecontents
A0000082biological_processG1/S transition of mitotic cell cycle
A0002931biological_processresponse to ischemia
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0004683molecular_functioncalmodulin-dependent protein kinase activity
A0005515molecular_functionprotein binding
A0005516molecular_functioncalmodulin binding
A0005524molecular_functionATP binding
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005829cellular_componentcytosol
A0005954cellular_componentcalcium- and calmodulin-dependent protein kinase complex
A0006468biological_processprotein phosphorylation
A0006816biological_processcalcium ion transport
A0009931molecular_functioncalcium-dependent protein serine/threonine kinase activity
A0010666biological_processpositive regulation of cardiac muscle cell apoptotic process
A0014069cellular_componentpostsynaptic density
A0016301molecular_functionkinase activity
A0030424cellular_componentaxon
A0030425cellular_componentdendrite
A0032794molecular_functionGTPase activating protein binding
A0032839cellular_componentdendrite cytoplasm
A0035235biological_processionotropic glutamate receptor signaling pathway
A0035254molecular_functionglutamate receptor binding
A0035458biological_processcellular response to interferon-beta
A0038166biological_processangiotensin-activated signaling pathway
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0042995cellular_componentcell projection
A0043005cellular_componentneuron projection
A0043025cellular_componentneuronal cell body
A0043197cellular_componentdendritic spine
A0043226cellular_componentorganelle
A0045202cellular_componentsynapse
A0045211cellular_componentpostsynaptic membrane
A0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
A0046872molecular_functionmetal ion binding
A0046928biological_processregulation of neurotransmitter secretion
A0048168biological_processregulation of neuronal synaptic plasticity
A0048813biological_processdendrite morphogenesis
A0051346biological_processnegative regulation of hydrolase activity
A0051928biological_processpositive regulation of calcium ion transport
A0060996biological_processdendritic spine development
A0071346biological_processcellular response to type II interferon
A0098685cellular_componentSchaffer collateral - CA1 synapse
A0098696biological_processregulation of neurotransmitter receptor localization to postsynaptic specialization membrane
A0098877biological_processneurotransmitter receptor transport to plasma membrane
A0098970biological_processpostsynaptic neurotransmitter receptor diffusion trapping
A0098978cellular_componentglutamatergic synapse
A0098989biological_processNMDA selective glutamate receptor signaling pathway
A0099004biological_processcalmodulin dependent kinase signaling pathway
A0099148biological_processregulation of synaptic vesicle docking
A0099523cellular_componentpresynaptic cytosol
A0099524cellular_componentpostsynaptic cytosol
A0099573cellular_componentglutamatergic postsynaptic density
A0099634cellular_componentpostsynaptic specialization membrane
A0106310molecular_functionprotein serine kinase activity
A1902108biological_processregulation of mitochondrial membrane permeability involved in apoptotic process
A1903076biological_processregulation of protein localization to plasma membrane
A1990443biological_processpeptidyl-threonine autophosphorylation
A2000124biological_processregulation of endocannabinoid signaling pathway
A2001222biological_processregulation of neuron migration
B0000082biological_processG1/S transition of mitotic cell cycle
B0002931biological_processresponse to ischemia
B0004672molecular_functionprotein kinase activity
B0004674molecular_functionprotein serine/threonine kinase activity
B0004683molecular_functioncalmodulin-dependent protein kinase activity
B0005515molecular_functionprotein binding
B0005516molecular_functioncalmodulin binding
B0005524molecular_functionATP binding
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005829cellular_componentcytosol
B0005954cellular_componentcalcium- and calmodulin-dependent protein kinase complex
B0006468biological_processprotein phosphorylation
B0006816biological_processcalcium ion transport
B0009931molecular_functioncalcium-dependent protein serine/threonine kinase activity
B0010666biological_processpositive regulation of cardiac muscle cell apoptotic process
B0014069cellular_componentpostsynaptic density
B0016301molecular_functionkinase activity
B0030424cellular_componentaxon
B0030425cellular_componentdendrite
B0032794molecular_functionGTPase activating protein binding
B0032839cellular_componentdendrite cytoplasm
B0035235biological_processionotropic glutamate receptor signaling pathway
B0035254molecular_functionglutamate receptor binding
B0035458biological_processcellular response to interferon-beta
B0038166biological_processangiotensin-activated signaling pathway
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0042995cellular_componentcell projection
B0043005cellular_componentneuron projection
B0043025cellular_componentneuronal cell body
B0043197cellular_componentdendritic spine
B0043226cellular_componentorganelle
B0045202cellular_componentsynapse
B0045211cellular_componentpostsynaptic membrane
B0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
B0046872molecular_functionmetal ion binding
B0046928biological_processregulation of neurotransmitter secretion
B0048168biological_processregulation of neuronal synaptic plasticity
B0048813biological_processdendrite morphogenesis
B0051346biological_processnegative regulation of hydrolase activity
B0051928biological_processpositive regulation of calcium ion transport
B0060996biological_processdendritic spine development
B0071346biological_processcellular response to type II interferon
B0098685cellular_componentSchaffer collateral - CA1 synapse
B0098696biological_processregulation of neurotransmitter receptor localization to postsynaptic specialization membrane
B0098877biological_processneurotransmitter receptor transport to plasma membrane
B0098970biological_processpostsynaptic neurotransmitter receptor diffusion trapping
B0098978cellular_componentglutamatergic synapse
B0098989biological_processNMDA selective glutamate receptor signaling pathway
B0099004biological_processcalmodulin dependent kinase signaling pathway
B0099148biological_processregulation of synaptic vesicle docking
B0099523cellular_componentpresynaptic cytosol
B0099524cellular_componentpostsynaptic cytosol
B0099573cellular_componentglutamatergic postsynaptic density
B0099634cellular_componentpostsynaptic specialization membrane
B0106310molecular_functionprotein serine kinase activity
B1902108biological_processregulation of mitochondrial membrane permeability involved in apoptotic process
B1903076biological_processregulation of protein localization to plasma membrane
B1990443biological_processpeptidyl-threonine autophosphorylation
B2000124biological_processregulation of endocannabinoid signaling pathway
B2001222biological_processregulation of neuron migration
C0000082biological_processG1/S transition of mitotic cell cycle
C0002931biological_processresponse to ischemia
C0004672molecular_functionprotein kinase activity
C0004674molecular_functionprotein serine/threonine kinase activity
C0004683molecular_functioncalmodulin-dependent protein kinase activity
C0005515molecular_functionprotein binding
C0005516molecular_functioncalmodulin binding
C0005524molecular_functionATP binding
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005829cellular_componentcytosol
C0005954cellular_componentcalcium- and calmodulin-dependent protein kinase complex
C0006468biological_processprotein phosphorylation
C0006816biological_processcalcium ion transport
C0009931molecular_functioncalcium-dependent protein serine/threonine kinase activity
C0010666biological_processpositive regulation of cardiac muscle cell apoptotic process
C0014069cellular_componentpostsynaptic density
C0016301molecular_functionkinase activity
C0030424cellular_componentaxon
C0030425cellular_componentdendrite
C0032794molecular_functionGTPase activating protein binding
C0032839cellular_componentdendrite cytoplasm
C0035235biological_processionotropic glutamate receptor signaling pathway
C0035254molecular_functionglutamate receptor binding
C0035458biological_processcellular response to interferon-beta
C0038166biological_processangiotensin-activated signaling pathway
C0042802molecular_functionidentical protein binding
C0042803molecular_functionprotein homodimerization activity
C0042995cellular_componentcell projection
C0043005cellular_componentneuron projection
C0043025cellular_componentneuronal cell body
C0043197cellular_componentdendritic spine
C0043226cellular_componentorganelle
C0045202cellular_componentsynapse
C0045211cellular_componentpostsynaptic membrane
C0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
C0046872molecular_functionmetal ion binding
C0046928biological_processregulation of neurotransmitter secretion
C0048168biological_processregulation of neuronal synaptic plasticity
C0048813biological_processdendrite morphogenesis
C0051346biological_processnegative regulation of hydrolase activity
C0051928biological_processpositive regulation of calcium ion transport
C0060996biological_processdendritic spine development
C0071346biological_processcellular response to type II interferon
C0098685cellular_componentSchaffer collateral - CA1 synapse
C0098696biological_processregulation of neurotransmitter receptor localization to postsynaptic specialization membrane
C0098877biological_processneurotransmitter receptor transport to plasma membrane
C0098970biological_processpostsynaptic neurotransmitter receptor diffusion trapping
C0098978cellular_componentglutamatergic synapse
C0098989biological_processNMDA selective glutamate receptor signaling pathway
C0099004biological_processcalmodulin dependent kinase signaling pathway
C0099148biological_processregulation of synaptic vesicle docking
C0099523cellular_componentpresynaptic cytosol
C0099524cellular_componentpostsynaptic cytosol
C0099573cellular_componentglutamatergic postsynaptic density
C0099634cellular_componentpostsynaptic specialization membrane
C0106310molecular_functionprotein serine kinase activity
C1902108biological_processregulation of mitochondrial membrane permeability involved in apoptotic process
C1903076biological_processregulation of protein localization to plasma membrane
C1990443biological_processpeptidyl-threonine autophosphorylation
C2000124biological_processregulation of endocannabinoid signaling pathway
C2001222biological_processregulation of neuron migration
D0000082biological_processG1/S transition of mitotic cell cycle
D0002931biological_processresponse to ischemia
D0004672molecular_functionprotein kinase activity
D0004674molecular_functionprotein serine/threonine kinase activity
D0004683molecular_functioncalmodulin-dependent protein kinase activity
D0005515molecular_functionprotein binding
D0005516molecular_functioncalmodulin binding
D0005524molecular_functionATP binding
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005829cellular_componentcytosol
D0005954cellular_componentcalcium- and calmodulin-dependent protein kinase complex
D0006468biological_processprotein phosphorylation
D0006816biological_processcalcium ion transport
D0009931molecular_functioncalcium-dependent protein serine/threonine kinase activity
D0010666biological_processpositive regulation of cardiac muscle cell apoptotic process
D0014069cellular_componentpostsynaptic density
D0016301molecular_functionkinase activity
D0030424cellular_componentaxon
D0030425cellular_componentdendrite
D0032794molecular_functionGTPase activating protein binding
D0032839cellular_componentdendrite cytoplasm
D0035235biological_processionotropic glutamate receptor signaling pathway
D0035254molecular_functionglutamate receptor binding
D0035458biological_processcellular response to interferon-beta
D0038166biological_processangiotensin-activated signaling pathway
D0042802molecular_functionidentical protein binding
D0042803molecular_functionprotein homodimerization activity
D0042995cellular_componentcell projection
D0043005cellular_componentneuron projection
D0043025cellular_componentneuronal cell body
D0043197cellular_componentdendritic spine
D0043226cellular_componentorganelle
D0045202cellular_componentsynapse
D0045211cellular_componentpostsynaptic membrane
D0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
D0046872molecular_functionmetal ion binding
D0046928biological_processregulation of neurotransmitter secretion
D0048168biological_processregulation of neuronal synaptic plasticity
D0048813biological_processdendrite morphogenesis
D0051346biological_processnegative regulation of hydrolase activity
D0051928biological_processpositive regulation of calcium ion transport
D0060996biological_processdendritic spine development
D0071346biological_processcellular response to type II interferon
D0098685cellular_componentSchaffer collateral - CA1 synapse
D0098696biological_processregulation of neurotransmitter receptor localization to postsynaptic specialization membrane
D0098877biological_processneurotransmitter receptor transport to plasma membrane
D0098970biological_processpostsynaptic neurotransmitter receptor diffusion trapping
D0098978cellular_componentglutamatergic synapse
D0098989biological_processNMDA selective glutamate receptor signaling pathway
D0099004biological_processcalmodulin dependent kinase signaling pathway
D0099148biological_processregulation of synaptic vesicle docking
D0099523cellular_componentpresynaptic cytosol
D0099524cellular_componentpostsynaptic cytosol
D0099573cellular_componentglutamatergic postsynaptic density
D0099634cellular_componentpostsynaptic specialization membrane
D0106310molecular_functionprotein serine kinase activity
D1902108biological_processregulation of mitochondrial membrane permeability involved in apoptotic process
D1903076biological_processregulation of protein localization to plasma membrane
D1990443biological_processpeptidyl-threonine autophosphorylation
D2000124biological_processregulation of endocannabinoid signaling pathway
D2001222biological_processregulation of neuron migration
E0000082biological_processG1/S transition of mitotic cell cycle
E0002931biological_processresponse to ischemia
E0004672molecular_functionprotein kinase activity
E0004674molecular_functionprotein serine/threonine kinase activity
E0004683molecular_functioncalmodulin-dependent protein kinase activity
E0005515molecular_functionprotein binding
E0005516molecular_functioncalmodulin binding
E0005524molecular_functionATP binding
E0005737cellular_componentcytoplasm
E0005739cellular_componentmitochondrion
E0005829cellular_componentcytosol
E0005954cellular_componentcalcium- and calmodulin-dependent protein kinase complex
E0006468biological_processprotein phosphorylation
E0006816biological_processcalcium ion transport
E0009931molecular_functioncalcium-dependent protein serine/threonine kinase activity
E0010666biological_processpositive regulation of cardiac muscle cell apoptotic process
E0014069cellular_componentpostsynaptic density
E0016301molecular_functionkinase activity
E0030424cellular_componentaxon
E0030425cellular_componentdendrite
E0032794molecular_functionGTPase activating protein binding
E0032839cellular_componentdendrite cytoplasm
E0035235biological_processionotropic glutamate receptor signaling pathway
E0035254molecular_functionglutamate receptor binding
E0035458biological_processcellular response to interferon-beta
E0038166biological_processangiotensin-activated signaling pathway
E0042802molecular_functionidentical protein binding
E0042803molecular_functionprotein homodimerization activity
E0042995cellular_componentcell projection
E0043005cellular_componentneuron projection
E0043025cellular_componentneuronal cell body
E0043197cellular_componentdendritic spine
E0043226cellular_componentorganelle
E0045202cellular_componentsynapse
E0045211cellular_componentpostsynaptic membrane
E0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
E0046872molecular_functionmetal ion binding
E0046928biological_processregulation of neurotransmitter secretion
E0048168biological_processregulation of neuronal synaptic plasticity
E0048813biological_processdendrite morphogenesis
E0051346biological_processnegative regulation of hydrolase activity
E0051928biological_processpositive regulation of calcium ion transport
E0060996biological_processdendritic spine development
E0071346biological_processcellular response to type II interferon
E0098685cellular_componentSchaffer collateral - CA1 synapse
E0098696biological_processregulation of neurotransmitter receptor localization to postsynaptic specialization membrane
E0098877biological_processneurotransmitter receptor transport to plasma membrane
E0098970biological_processpostsynaptic neurotransmitter receptor diffusion trapping
E0098978cellular_componentglutamatergic synapse
E0098989biological_processNMDA selective glutamate receptor signaling pathway
E0099004biological_processcalmodulin dependent kinase signaling pathway
E0099148biological_processregulation of synaptic vesicle docking
E0099523cellular_componentpresynaptic cytosol
E0099524cellular_componentpostsynaptic cytosol
E0099573cellular_componentglutamatergic postsynaptic density
E0099634cellular_componentpostsynaptic specialization membrane
E0106310molecular_functionprotein serine kinase activity
E1902108biological_processregulation of mitochondrial membrane permeability involved in apoptotic process
E1903076biological_processregulation of protein localization to plasma membrane
E1990443biological_processpeptidyl-threonine autophosphorylation
E2000124biological_processregulation of endocannabinoid signaling pathway
E2001222biological_processregulation of neuron migration
F0000082biological_processG1/S transition of mitotic cell cycle
F0002931biological_processresponse to ischemia
F0004672molecular_functionprotein kinase activity
F0004674molecular_functionprotein serine/threonine kinase activity
F0004683molecular_functioncalmodulin-dependent protein kinase activity
F0005515molecular_functionprotein binding
F0005516molecular_functioncalmodulin binding
F0005524molecular_functionATP binding
F0005737cellular_componentcytoplasm
F0005739cellular_componentmitochondrion
F0005829cellular_componentcytosol
F0005954cellular_componentcalcium- and calmodulin-dependent protein kinase complex
F0006468biological_processprotein phosphorylation
F0006816biological_processcalcium ion transport
F0009931molecular_functioncalcium-dependent protein serine/threonine kinase activity
F0010666biological_processpositive regulation of cardiac muscle cell apoptotic process
F0014069cellular_componentpostsynaptic density
F0016301molecular_functionkinase activity
F0030424cellular_componentaxon
F0030425cellular_componentdendrite
F0032794molecular_functionGTPase activating protein binding
F0032839cellular_componentdendrite cytoplasm
F0035235biological_processionotropic glutamate receptor signaling pathway
F0035254molecular_functionglutamate receptor binding
F0035458biological_processcellular response to interferon-beta
F0038166biological_processangiotensin-activated signaling pathway
F0042802molecular_functionidentical protein binding
F0042803molecular_functionprotein homodimerization activity
F0042995cellular_componentcell projection
F0043005cellular_componentneuron projection
F0043025cellular_componentneuronal cell body
F0043197cellular_componentdendritic spine
F0043226cellular_componentorganelle
F0045202cellular_componentsynapse
F0045211cellular_componentpostsynaptic membrane
F0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
F0046872molecular_functionmetal ion binding
F0046928biological_processregulation of neurotransmitter secretion
F0048168biological_processregulation of neuronal synaptic plasticity
F0048813biological_processdendrite morphogenesis
F0051346biological_processnegative regulation of hydrolase activity
F0051928biological_processpositive regulation of calcium ion transport
F0060996biological_processdendritic spine development
F0071346biological_processcellular response to type II interferon
F0098685cellular_componentSchaffer collateral - CA1 synapse
F0098696biological_processregulation of neurotransmitter receptor localization to postsynaptic specialization membrane
F0098877biological_processneurotransmitter receptor transport to plasma membrane
F0098970biological_processpostsynaptic neurotransmitter receptor diffusion trapping
F0098978cellular_componentglutamatergic synapse
F0098989biological_processNMDA selective glutamate receptor signaling pathway
F0099004biological_processcalmodulin dependent kinase signaling pathway
F0099148biological_processregulation of synaptic vesicle docking
F0099523cellular_componentpresynaptic cytosol
F0099524cellular_componentpostsynaptic cytosol
F0099573cellular_componentglutamatergic postsynaptic density
F0099634cellular_componentpostsynaptic specialization membrane
F0106310molecular_functionprotein serine kinase activity
F1902108biological_processregulation of mitochondrial membrane permeability involved in apoptotic process
F1903076biological_processregulation of protein localization to plasma membrane
F1990443biological_processpeptidyl-threonine autophosphorylation
F2000124biological_processregulation of endocannabinoid signaling pathway
F2001222biological_processregulation of neuron migration
G0000082biological_processG1/S transition of mitotic cell cycle
G0002931biological_processresponse to ischemia
G0004672molecular_functionprotein kinase activity
G0004674molecular_functionprotein serine/threonine kinase activity
G0004683molecular_functioncalmodulin-dependent protein kinase activity
G0005515molecular_functionprotein binding
G0005516molecular_functioncalmodulin binding
G0005524molecular_functionATP binding
G0005737cellular_componentcytoplasm
G0005739cellular_componentmitochondrion
G0005829cellular_componentcytosol
G0005954cellular_componentcalcium- and calmodulin-dependent protein kinase complex
G0006468biological_processprotein phosphorylation
G0006816biological_processcalcium ion transport
G0009931molecular_functioncalcium-dependent protein serine/threonine kinase activity
G0010666biological_processpositive regulation of cardiac muscle cell apoptotic process
G0014069cellular_componentpostsynaptic density
G0016301molecular_functionkinase activity
G0030424cellular_componentaxon
G0030425cellular_componentdendrite
G0032794molecular_functionGTPase activating protein binding
G0032839cellular_componentdendrite cytoplasm
G0035235biological_processionotropic glutamate receptor signaling pathway
G0035254molecular_functionglutamate receptor binding
G0035458biological_processcellular response to interferon-beta
G0038166biological_processangiotensin-activated signaling pathway
G0042802molecular_functionidentical protein binding
G0042803molecular_functionprotein homodimerization activity
G0042995cellular_componentcell projection
G0043005cellular_componentneuron projection
G0043025cellular_componentneuronal cell body
G0043197cellular_componentdendritic spine
G0043226cellular_componentorganelle
G0045202cellular_componentsynapse
G0045211cellular_componentpostsynaptic membrane
G0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
G0046872molecular_functionmetal ion binding
G0046928biological_processregulation of neurotransmitter secretion
G0048168biological_processregulation of neuronal synaptic plasticity
G0048813biological_processdendrite morphogenesis
G0051346biological_processnegative regulation of hydrolase activity
G0051928biological_processpositive regulation of calcium ion transport
G0060996biological_processdendritic spine development
G0071346biological_processcellular response to type II interferon
G0098685cellular_componentSchaffer collateral - CA1 synapse
G0098696biological_processregulation of neurotransmitter receptor localization to postsynaptic specialization membrane
G0098877biological_processneurotransmitter receptor transport to plasma membrane
G0098970biological_processpostsynaptic neurotransmitter receptor diffusion trapping
G0098978cellular_componentglutamatergic synapse
G0098989biological_processNMDA selective glutamate receptor signaling pathway
G0099004biological_processcalmodulin dependent kinase signaling pathway
G0099148biological_processregulation of synaptic vesicle docking
G0099523cellular_componentpresynaptic cytosol
G0099524cellular_componentpostsynaptic cytosol
G0099573cellular_componentglutamatergic postsynaptic density
G0099634cellular_componentpostsynaptic specialization membrane
G0106310molecular_functionprotein serine kinase activity
G1902108biological_processregulation of mitochondrial membrane permeability involved in apoptotic process
G1903076biological_processregulation of protein localization to plasma membrane
G1990443biological_processpeptidyl-threonine autophosphorylation
G2000124biological_processregulation of endocannabinoid signaling pathway
G2001222biological_processregulation of neuron migration
H0000082biological_processG1/S transition of mitotic cell cycle
H0002931biological_processresponse to ischemia
H0004672molecular_functionprotein kinase activity
H0004674molecular_functionprotein serine/threonine kinase activity
H0004683molecular_functioncalmodulin-dependent protein kinase activity
H0005515molecular_functionprotein binding
H0005516molecular_functioncalmodulin binding
H0005524molecular_functionATP binding
H0005737cellular_componentcytoplasm
H0005739cellular_componentmitochondrion
H0005829cellular_componentcytosol
H0005954cellular_componentcalcium- and calmodulin-dependent protein kinase complex
H0006468biological_processprotein phosphorylation
H0006816biological_processcalcium ion transport
H0009931molecular_functioncalcium-dependent protein serine/threonine kinase activity
H0010666biological_processpositive regulation of cardiac muscle cell apoptotic process
H0014069cellular_componentpostsynaptic density
H0016301molecular_functionkinase activity
H0030424cellular_componentaxon
H0030425cellular_componentdendrite
H0032794molecular_functionGTPase activating protein binding
H0032839cellular_componentdendrite cytoplasm
H0035235biological_processionotropic glutamate receptor signaling pathway
H0035254molecular_functionglutamate receptor binding
H0035458biological_processcellular response to interferon-beta
H0038166biological_processangiotensin-activated signaling pathway
H0042802molecular_functionidentical protein binding
H0042803molecular_functionprotein homodimerization activity
H0042995cellular_componentcell projection
H0043005cellular_componentneuron projection
H0043025cellular_componentneuronal cell body
H0043197cellular_componentdendritic spine
H0043226cellular_componentorganelle
H0045202cellular_componentsynapse
H0045211cellular_componentpostsynaptic membrane
H0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
H0046872molecular_functionmetal ion binding
H0046928biological_processregulation of neurotransmitter secretion
H0048168biological_processregulation of neuronal synaptic plasticity
H0048813biological_processdendrite morphogenesis
H0051346biological_processnegative regulation of hydrolase activity
H0051928biological_processpositive regulation of calcium ion transport
H0060996biological_processdendritic spine development
H0071346biological_processcellular response to type II interferon
H0098685cellular_componentSchaffer collateral - CA1 synapse
H0098696biological_processregulation of neurotransmitter receptor localization to postsynaptic specialization membrane
H0098877biological_processneurotransmitter receptor transport to plasma membrane
H0098970biological_processpostsynaptic neurotransmitter receptor diffusion trapping
H0098978cellular_componentglutamatergic synapse
H0098989biological_processNMDA selective glutamate receptor signaling pathway
H0099004biological_processcalmodulin dependent kinase signaling pathway
H0099148biological_processregulation of synaptic vesicle docking
H0099523cellular_componentpresynaptic cytosol
H0099524cellular_componentpostsynaptic cytosol
H0099573cellular_componentglutamatergic postsynaptic density
H0099634cellular_componentpostsynaptic specialization membrane
H0106310molecular_functionprotein serine kinase activity
H1902108biological_processregulation of mitochondrial membrane permeability involved in apoptotic process
H1903076biological_processregulation of protein localization to plasma membrane
H1990443biological_processpeptidyl-threonine autophosphorylation
H2000124biological_processregulation of endocannabinoid signaling pathway
H2001222biological_processregulation of neuron migration
I0000082biological_processG1/S transition of mitotic cell cycle
I0002931biological_processresponse to ischemia
I0004672molecular_functionprotein kinase activity
I0004674molecular_functionprotein serine/threonine kinase activity
I0004683molecular_functioncalmodulin-dependent protein kinase activity
I0005515molecular_functionprotein binding
I0005516molecular_functioncalmodulin binding
I0005524molecular_functionATP binding
I0005737cellular_componentcytoplasm
I0005739cellular_componentmitochondrion
I0005829cellular_componentcytosol
I0005954cellular_componentcalcium- and calmodulin-dependent protein kinase complex
I0006468biological_processprotein phosphorylation
I0006816biological_processcalcium ion transport
I0009931molecular_functioncalcium-dependent protein serine/threonine kinase activity
I0010666biological_processpositive regulation of cardiac muscle cell apoptotic process
I0014069cellular_componentpostsynaptic density
I0016301molecular_functionkinase activity
I0030424cellular_componentaxon
I0030425cellular_componentdendrite
I0032794molecular_functionGTPase activating protein binding
I0032839cellular_componentdendrite cytoplasm
I0035235biological_processionotropic glutamate receptor signaling pathway
I0035254molecular_functionglutamate receptor binding
I0035458biological_processcellular response to interferon-beta
I0038166biological_processangiotensin-activated signaling pathway
I0042802molecular_functionidentical protein binding
I0042803molecular_functionprotein homodimerization activity
I0042995cellular_componentcell projection
I0043005cellular_componentneuron projection
I0043025cellular_componentneuronal cell body
I0043197cellular_componentdendritic spine
I0043226cellular_componentorganelle
I0045202cellular_componentsynapse
I0045211cellular_componentpostsynaptic membrane
I0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
I0046872molecular_functionmetal ion binding
I0046928biological_processregulation of neurotransmitter secretion
I0048168biological_processregulation of neuronal synaptic plasticity
I0048813biological_processdendrite morphogenesis
I0051346biological_processnegative regulation of hydrolase activity
I0051928biological_processpositive regulation of calcium ion transport
I0060996biological_processdendritic spine development
I0071346biological_processcellular response to type II interferon
I0098685cellular_componentSchaffer collateral - CA1 synapse
I0098696biological_processregulation of neurotransmitter receptor localization to postsynaptic specialization membrane
I0098877biological_processneurotransmitter receptor transport to plasma membrane
I0098970biological_processpostsynaptic neurotransmitter receptor diffusion trapping
I0098978cellular_componentglutamatergic synapse
I0098989biological_processNMDA selective glutamate receptor signaling pathway
I0099004biological_processcalmodulin dependent kinase signaling pathway
I0099148biological_processregulation of synaptic vesicle docking
I0099523cellular_componentpresynaptic cytosol
I0099524cellular_componentpostsynaptic cytosol
I0099573cellular_componentglutamatergic postsynaptic density
I0099634cellular_componentpostsynaptic specialization membrane
I0106310molecular_functionprotein serine kinase activity
I1902108biological_processregulation of mitochondrial membrane permeability involved in apoptotic process
I1903076biological_processregulation of protein localization to plasma membrane
I1990443biological_processpeptidyl-threonine autophosphorylation
I2000124biological_processregulation of endocannabinoid signaling pathway
I2001222biological_processregulation of neuron migration
J0000082biological_processG1/S transition of mitotic cell cycle
J0002931biological_processresponse to ischemia
J0004672molecular_functionprotein kinase activity
J0004674molecular_functionprotein serine/threonine kinase activity
J0004683molecular_functioncalmodulin-dependent protein kinase activity
J0005515molecular_functionprotein binding
J0005516molecular_functioncalmodulin binding
J0005524molecular_functionATP binding
J0005737cellular_componentcytoplasm
J0005739cellular_componentmitochondrion
J0005829cellular_componentcytosol
J0005954cellular_componentcalcium- and calmodulin-dependent protein kinase complex
J0006468biological_processprotein phosphorylation
J0006816biological_processcalcium ion transport
J0009931molecular_functioncalcium-dependent protein serine/threonine kinase activity
J0010666biological_processpositive regulation of cardiac muscle cell apoptotic process
J0014069cellular_componentpostsynaptic density
J0016301molecular_functionkinase activity
J0030424cellular_componentaxon
J0030425cellular_componentdendrite
J0032794molecular_functionGTPase activating protein binding
J0032839cellular_componentdendrite cytoplasm
J0035235biological_processionotropic glutamate receptor signaling pathway
J0035254molecular_functionglutamate receptor binding
J0035458biological_processcellular response to interferon-beta
J0038166biological_processangiotensin-activated signaling pathway
J0042802molecular_functionidentical protein binding
J0042803molecular_functionprotein homodimerization activity
J0042995cellular_componentcell projection
J0043005cellular_componentneuron projection
J0043025cellular_componentneuronal cell body
J0043197cellular_componentdendritic spine
J0043226cellular_componentorganelle
J0045202cellular_componentsynapse
J0045211cellular_componentpostsynaptic membrane
J0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
J0046872molecular_functionmetal ion binding
J0046928biological_processregulation of neurotransmitter secretion
J0048168biological_processregulation of neuronal synaptic plasticity
J0048813biological_processdendrite morphogenesis
J0051346biological_processnegative regulation of hydrolase activity
J0051928biological_processpositive regulation of calcium ion transport
J0060996biological_processdendritic spine development
J0071346biological_processcellular response to type II interferon
J0098685cellular_componentSchaffer collateral - CA1 synapse
J0098696biological_processregulation of neurotransmitter receptor localization to postsynaptic specialization membrane
J0098877biological_processneurotransmitter receptor transport to plasma membrane
J0098970biological_processpostsynaptic neurotransmitter receptor diffusion trapping
J0098978cellular_componentglutamatergic synapse
J0098989biological_processNMDA selective glutamate receptor signaling pathway
J0099004biological_processcalmodulin dependent kinase signaling pathway
J0099148biological_processregulation of synaptic vesicle docking
J0099523cellular_componentpresynaptic cytosol
J0099524cellular_componentpostsynaptic cytosol
J0099573cellular_componentglutamatergic postsynaptic density
J0099634cellular_componentpostsynaptic specialization membrane
J0106310molecular_functionprotein serine kinase activity
J1902108biological_processregulation of mitochondrial membrane permeability involved in apoptotic process
J1903076biological_processregulation of protein localization to plasma membrane
J1990443biological_processpeptidyl-threonine autophosphorylation
J2000124biological_processregulation of endocannabinoid signaling pathway
J2001222biological_processregulation of neuron migration
K0000082biological_processG1/S transition of mitotic cell cycle
K0002931biological_processresponse to ischemia
K0004672molecular_functionprotein kinase activity
K0004674molecular_functionprotein serine/threonine kinase activity
K0004683molecular_functioncalmodulin-dependent protein kinase activity
K0005515molecular_functionprotein binding
K0005516molecular_functioncalmodulin binding
K0005524molecular_functionATP binding
K0005737cellular_componentcytoplasm
K0005739cellular_componentmitochondrion
K0005829cellular_componentcytosol
K0005954cellular_componentcalcium- and calmodulin-dependent protein kinase complex
K0006468biological_processprotein phosphorylation
K0006816biological_processcalcium ion transport
K0009931molecular_functioncalcium-dependent protein serine/threonine kinase activity
K0010666biological_processpositive regulation of cardiac muscle cell apoptotic process
K0014069cellular_componentpostsynaptic density
K0016301molecular_functionkinase activity
K0030424cellular_componentaxon
K0030425cellular_componentdendrite
K0032794molecular_functionGTPase activating protein binding
K0032839cellular_componentdendrite cytoplasm
K0035235biological_processionotropic glutamate receptor signaling pathway
K0035254molecular_functionglutamate receptor binding
K0035458biological_processcellular response to interferon-beta
K0038166biological_processangiotensin-activated signaling pathway
K0042802molecular_functionidentical protein binding
K0042803molecular_functionprotein homodimerization activity
K0042995cellular_componentcell projection
K0043005cellular_componentneuron projection
K0043025cellular_componentneuronal cell body
K0043197cellular_componentdendritic spine
K0043226cellular_componentorganelle
K0045202cellular_componentsynapse
K0045211cellular_componentpostsynaptic membrane
K0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
K0046872molecular_functionmetal ion binding
K0046928biological_processregulation of neurotransmitter secretion
K0048168biological_processregulation of neuronal synaptic plasticity
K0048813biological_processdendrite morphogenesis
K0051346biological_processnegative regulation of hydrolase activity
K0051928biological_processpositive regulation of calcium ion transport
K0060996biological_processdendritic spine development
K0071346biological_processcellular response to type II interferon
K0098685cellular_componentSchaffer collateral - CA1 synapse
K0098696biological_processregulation of neurotransmitter receptor localization to postsynaptic specialization membrane
K0098877biological_processneurotransmitter receptor transport to plasma membrane
K0098970biological_processpostsynaptic neurotransmitter receptor diffusion trapping
K0098978cellular_componentglutamatergic synapse
K0098989biological_processNMDA selective glutamate receptor signaling pathway
K0099004biological_processcalmodulin dependent kinase signaling pathway
K0099148biological_processregulation of synaptic vesicle docking
K0099523cellular_componentpresynaptic cytosol
K0099524cellular_componentpostsynaptic cytosol
K0099573cellular_componentglutamatergic postsynaptic density
K0099634cellular_componentpostsynaptic specialization membrane
K0106310molecular_functionprotein serine kinase activity
K1902108biological_processregulation of mitochondrial membrane permeability involved in apoptotic process
K1903076biological_processregulation of protein localization to plasma membrane
K1990443biological_processpeptidyl-threonine autophosphorylation
K2000124biological_processregulation of endocannabinoid signaling pathway
K2001222biological_processregulation of neuron migration
L0000082biological_processG1/S transition of mitotic cell cycle
L0002931biological_processresponse to ischemia
L0004672molecular_functionprotein kinase activity
L0004674molecular_functionprotein serine/threonine kinase activity
L0004683molecular_functioncalmodulin-dependent protein kinase activity
L0005515molecular_functionprotein binding
L0005516molecular_functioncalmodulin binding
L0005524molecular_functionATP binding
L0005737cellular_componentcytoplasm
L0005739cellular_componentmitochondrion
L0005829cellular_componentcytosol
L0005954cellular_componentcalcium- and calmodulin-dependent protein kinase complex
L0006468biological_processprotein phosphorylation
L0006816biological_processcalcium ion transport
L0009931molecular_functioncalcium-dependent protein serine/threonine kinase activity
L0010666biological_processpositive regulation of cardiac muscle cell apoptotic process
L0014069cellular_componentpostsynaptic density
L0016301molecular_functionkinase activity
L0030424cellular_componentaxon
L0030425cellular_componentdendrite
L0032794molecular_functionGTPase activating protein binding
L0032839cellular_componentdendrite cytoplasm
L0035235biological_processionotropic glutamate receptor signaling pathway
L0035254molecular_functionglutamate receptor binding
L0035458biological_processcellular response to interferon-beta
L0038166biological_processangiotensin-activated signaling pathway
L0042802molecular_functionidentical protein binding
L0042803molecular_functionprotein homodimerization activity
L0042995cellular_componentcell projection
L0043005cellular_componentneuron projection
L0043025cellular_componentneuronal cell body
L0043197cellular_componentdendritic spine
L0043226cellular_componentorganelle
L0045202cellular_componentsynapse
L0045211cellular_componentpostsynaptic membrane
L0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
L0046872molecular_functionmetal ion binding
L0046928biological_processregulation of neurotransmitter secretion
L0048168biological_processregulation of neuronal synaptic plasticity
L0048813biological_processdendrite morphogenesis
L0051346biological_processnegative regulation of hydrolase activity
L0051928biological_processpositive regulation of calcium ion transport
L0060996biological_processdendritic spine development
L0071346biological_processcellular response to type II interferon
L0098685cellular_componentSchaffer collateral - CA1 synapse
L0098696biological_processregulation of neurotransmitter receptor localization to postsynaptic specialization membrane
L0098877biological_processneurotransmitter receptor transport to plasma membrane
L0098970biological_processpostsynaptic neurotransmitter receptor diffusion trapping
L0098978cellular_componentglutamatergic synapse
L0098989biological_processNMDA selective glutamate receptor signaling pathway
L0099004biological_processcalmodulin dependent kinase signaling pathway
L0099148biological_processregulation of synaptic vesicle docking
L0099523cellular_componentpresynaptic cytosol
L0099524cellular_componentpostsynaptic cytosol
L0099573cellular_componentglutamatergic postsynaptic density
L0099634cellular_componentpostsynaptic specialization membrane
L0106310molecular_functionprotein serine kinase activity
L1902108biological_processregulation of mitochondrial membrane permeability involved in apoptotic process
L1903076biological_processregulation of protein localization to plasma membrane
L1990443biological_processpeptidyl-threonine autophosphorylation
L2000124biological_processregulation of endocannabinoid signaling pathway
L2001222biological_processregulation of neuron migration
Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues24
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGKGAFSVVRrCvkvlagqe..........YAAK
ChainResidueDetails
ALEU19-LYS42

site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VvHrDLKpeNLLL
ChainResidueDetails
AVAL131-LEU143

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues12
DetailsACT_SITE: Proton acceptor
ChainResidueDetails
AASP135
BASP135
CASP135
DASP135
EASP135
FASP135
GASP135
HASP135
IASP135
JASP135
KASP135
LASP135

site_idSWS_FT_FI2
Number of Residues24
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
ChainResidueDetails
GLEU19
GLYS42
HLEU19
HLYS42
ILEU19
ILYS42
JLEU19
JLYS42
KLEU19
KLYS42
LLEU19
LLYS42
ALEU19
ALYS42
BLEU19
BLYS42
CLEU19
CLYS42
DLEU19
DLYS42
ELEU19
ELYS42
FLEU19
FLYS42

site_idSWS_FT_FI3
Number of Residues12
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P11798
ChainResidueDetails
ATYR13
BTYR13
CTYR13
DTYR13
ETYR13
FTYR13
GTYR13
ITYR13
JTYR13
KTYR13
LTYR13
HTYR13

site_idSWS_FT_FI4
Number of Residues24
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:22673903
ChainResidueDetails
GSER257
GSER404
HSER257
HSER404
ISER257
ISER404
JSER257
JSER404
KSER257
KSER404
LSER257
LSER404
ASER257
ASER404
BSER257
BSER404
CSER257
CSER404
DSER257
DSER404
ESER257
ESER404
FSER257
FSER404

site_idSWS_FT_FI5
Number of Residues12
DetailsMOD_RES: Phosphothreonine; by autocatalysis => ECO:0000269|PubMed:2842767
ChainResidueDetails
FTHR286
GTHR286
HTHR286
ITHR286
JTHR286
KTHR286
LTHR286
ATHR286
BTHR286
CTHR286
DTHR286
ETHR286

site_idSWS_FT_FI6
Number of Residues36
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P11798
ChainResidueDetails
ESER330
ESER331
ESER333
FSER330
FSER331
FSER333
GSER330
GSER331
GSER333
HSER330
HSER331
HSER333
ISER330
ISER331
ISER333
JSER330
JSER331
JSER333
KSER330
KSER331
KSER333
LSER330
LSER331
LSER333
ASER330
ASER331
ASER333
BSER330
BSER331
BSER333
CSER330
CSER331
CSER333
DSER330
DSER331
DSER333

site_idSWS_FT_FI7
Number of Residues24
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P11798
ChainResidueDetails
DTHR337
ETHR336
ETHR337
FTHR336
FTHR337
GTHR336
GTHR337
HTHR336
HTHR337
JTHR337
KTHR336
KTHR337
LTHR336
LTHR337
ATHR336
ATHR337
BTHR336
BTHR337
CTHR336
CTHR337
DTHR336
ITHR336
ITHR337
JTHR336

221051

PDB entries from 2024-06-12

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