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5U6Y

Pseudo-atomic model of the CaMKIIa holoenzyme.

Functional Information from GO Data
ChainGOidnamespacecontents
A0000082biological_processG1/S transition of mitotic cell cycle
A0000166molecular_functionnucleotide binding
A0002931biological_processresponse to ischemia
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0004683molecular_functioncalcium/calmodulin-dependent protein kinase activity
A0005515molecular_functionprotein binding
A0005516molecular_functioncalmodulin binding
A0005524molecular_functionATP binding
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005829cellular_componentcytosol
A0005954cellular_componentcalcium- and calmodulin-dependent protein kinase complex
A0006468biological_processprotein phosphorylation
A0006816biological_processcalcium ion transport
A0010666biological_processpositive regulation of cardiac muscle cell apoptotic process
A0014069cellular_componentpostsynaptic density
A0016301molecular_functionkinase activity
A0016740molecular_functiontransferase activity
A0018105biological_processpeptidyl-serine phosphorylation
A0030424cellular_componentaxon
A0030425cellular_componentdendrite
A0032794molecular_functionGTPase activating protein binding
A0032839cellular_componentdendrite cytoplasm
A0035235biological_processionotropic glutamate receptor signaling pathway
A0035254molecular_functionglutamate receptor binding
A0035458biological_processcellular response to interferon-beta
A0038166biological_processangiotensin-activated signaling pathway
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0043005cellular_componentneuron projection
A0043025cellular_componentneuronal cell body
A0043197cellular_componentdendritic spine
A0043226cellular_componentorganelle
A0045202cellular_componentsynapse
A0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
A0046777biological_processprotein autophosphorylation
A0046872molecular_functionmetal ion binding
A0046928biological_processregulation of neurotransmitter secretion
A0048168biological_processregulation of neuronal synaptic plasticity
A0048813biological_processdendrite morphogenesis
A0051346biological_processnegative regulation of hydrolase activity
A0051928biological_processpositive regulation of calcium ion transport
A0060996biological_processdendritic spine development
A0071346biological_processcellular response to type II interferon
A0098685cellular_componentSchaffer collateral - CA1 synapse
A0098696biological_processregulation of neurotransmitter receptor localization to postsynaptic specialization membrane
A0098877biological_processneurotransmitter receptor transport to plasma membrane
A0098978cellular_componentglutamatergic synapse
A0099148biological_processregulation of synaptic vesicle docking
A0099523cellular_componentpresynaptic cytosol
A0099524cellular_componentpostsynaptic cytosol
A0106310molecular_functionprotein serine kinase activity
A0110076biological_processnegative regulation of ferroptosis
A1902108biological_processregulation of mitochondrial membrane permeability involved in apoptotic process
A1903076biological_processregulation of protein localization to plasma membrane
A1990443biological_processpeptidyl-threonine autophosphorylation
A2000124biological_processregulation of endocannabinoid signaling pathway
A2001222biological_processregulation of neuron migration
B0000082biological_processG1/S transition of mitotic cell cycle
B0000166molecular_functionnucleotide binding
B0002931biological_processresponse to ischemia
B0004672molecular_functionprotein kinase activity
B0004674molecular_functionprotein serine/threonine kinase activity
B0004683molecular_functioncalcium/calmodulin-dependent protein kinase activity
B0005515molecular_functionprotein binding
B0005516molecular_functioncalmodulin binding
B0005524molecular_functionATP binding
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005829cellular_componentcytosol
B0005954cellular_componentcalcium- and calmodulin-dependent protein kinase complex
B0006468biological_processprotein phosphorylation
B0006816biological_processcalcium ion transport
B0010666biological_processpositive regulation of cardiac muscle cell apoptotic process
B0014069cellular_componentpostsynaptic density
B0016301molecular_functionkinase activity
B0016740molecular_functiontransferase activity
B0018105biological_processpeptidyl-serine phosphorylation
B0030424cellular_componentaxon
B0030425cellular_componentdendrite
B0032794molecular_functionGTPase activating protein binding
B0032839cellular_componentdendrite cytoplasm
B0035235biological_processionotropic glutamate receptor signaling pathway
B0035254molecular_functionglutamate receptor binding
B0035458biological_processcellular response to interferon-beta
B0038166biological_processangiotensin-activated signaling pathway
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0043005cellular_componentneuron projection
B0043025cellular_componentneuronal cell body
B0043197cellular_componentdendritic spine
B0043226cellular_componentorganelle
B0045202cellular_componentsynapse
B0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
B0046777biological_processprotein autophosphorylation
B0046872molecular_functionmetal ion binding
B0046928biological_processregulation of neurotransmitter secretion
B0048168biological_processregulation of neuronal synaptic plasticity
B0048813biological_processdendrite morphogenesis
B0051346biological_processnegative regulation of hydrolase activity
B0051928biological_processpositive regulation of calcium ion transport
B0060996biological_processdendritic spine development
B0071346biological_processcellular response to type II interferon
B0098685cellular_componentSchaffer collateral - CA1 synapse
B0098696biological_processregulation of neurotransmitter receptor localization to postsynaptic specialization membrane
B0098877biological_processneurotransmitter receptor transport to plasma membrane
B0098978cellular_componentglutamatergic synapse
B0099148biological_processregulation of synaptic vesicle docking
B0099523cellular_componentpresynaptic cytosol
B0099524cellular_componentpostsynaptic cytosol
B0106310molecular_functionprotein serine kinase activity
B0110076biological_processnegative regulation of ferroptosis
B1902108biological_processregulation of mitochondrial membrane permeability involved in apoptotic process
B1903076biological_processregulation of protein localization to plasma membrane
B1990443biological_processpeptidyl-threonine autophosphorylation
B2000124biological_processregulation of endocannabinoid signaling pathway
B2001222biological_processregulation of neuron migration
C0000082biological_processG1/S transition of mitotic cell cycle
C0000166molecular_functionnucleotide binding
C0002931biological_processresponse to ischemia
C0004672molecular_functionprotein kinase activity
C0004674molecular_functionprotein serine/threonine kinase activity
C0004683molecular_functioncalcium/calmodulin-dependent protein kinase activity
C0005515molecular_functionprotein binding
C0005516molecular_functioncalmodulin binding
C0005524molecular_functionATP binding
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005829cellular_componentcytosol
C0005954cellular_componentcalcium- and calmodulin-dependent protein kinase complex
C0006468biological_processprotein phosphorylation
C0006816biological_processcalcium ion transport
C0010666biological_processpositive regulation of cardiac muscle cell apoptotic process
C0014069cellular_componentpostsynaptic density
C0016301molecular_functionkinase activity
C0016740molecular_functiontransferase activity
C0018105biological_processpeptidyl-serine phosphorylation
C0030424cellular_componentaxon
C0030425cellular_componentdendrite
C0032794molecular_functionGTPase activating protein binding
C0032839cellular_componentdendrite cytoplasm
C0035235biological_processionotropic glutamate receptor signaling pathway
C0035254molecular_functionglutamate receptor binding
C0035458biological_processcellular response to interferon-beta
C0038166biological_processangiotensin-activated signaling pathway
C0042802molecular_functionidentical protein binding
C0042803molecular_functionprotein homodimerization activity
C0043005cellular_componentneuron projection
C0043025cellular_componentneuronal cell body
C0043197cellular_componentdendritic spine
C0043226cellular_componentorganelle
C0045202cellular_componentsynapse
C0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
C0046777biological_processprotein autophosphorylation
C0046872molecular_functionmetal ion binding
C0046928biological_processregulation of neurotransmitter secretion
C0048168biological_processregulation of neuronal synaptic plasticity
C0048813biological_processdendrite morphogenesis
C0051346biological_processnegative regulation of hydrolase activity
C0051928biological_processpositive regulation of calcium ion transport
C0060996biological_processdendritic spine development
C0071346biological_processcellular response to type II interferon
C0098685cellular_componentSchaffer collateral - CA1 synapse
C0098696biological_processregulation of neurotransmitter receptor localization to postsynaptic specialization membrane
C0098877biological_processneurotransmitter receptor transport to plasma membrane
C0098978cellular_componentglutamatergic synapse
C0099148biological_processregulation of synaptic vesicle docking
C0099523cellular_componentpresynaptic cytosol
C0099524cellular_componentpostsynaptic cytosol
C0106310molecular_functionprotein serine kinase activity
C0110076biological_processnegative regulation of ferroptosis
C1902108biological_processregulation of mitochondrial membrane permeability involved in apoptotic process
C1903076biological_processregulation of protein localization to plasma membrane
C1990443biological_processpeptidyl-threonine autophosphorylation
C2000124biological_processregulation of endocannabinoid signaling pathway
C2001222biological_processregulation of neuron migration
D0000082biological_processG1/S transition of mitotic cell cycle
D0000166molecular_functionnucleotide binding
D0002931biological_processresponse to ischemia
D0004672molecular_functionprotein kinase activity
D0004674molecular_functionprotein serine/threonine kinase activity
D0004683molecular_functioncalcium/calmodulin-dependent protein kinase activity
D0005515molecular_functionprotein binding
D0005516molecular_functioncalmodulin binding
D0005524molecular_functionATP binding
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005829cellular_componentcytosol
D0005954cellular_componentcalcium- and calmodulin-dependent protein kinase complex
D0006468biological_processprotein phosphorylation
D0006816biological_processcalcium ion transport
D0010666biological_processpositive regulation of cardiac muscle cell apoptotic process
D0014069cellular_componentpostsynaptic density
D0016301molecular_functionkinase activity
D0016740molecular_functiontransferase activity
D0018105biological_processpeptidyl-serine phosphorylation
D0030424cellular_componentaxon
D0030425cellular_componentdendrite
D0032794molecular_functionGTPase activating protein binding
D0032839cellular_componentdendrite cytoplasm
D0035235biological_processionotropic glutamate receptor signaling pathway
D0035254molecular_functionglutamate receptor binding
D0035458biological_processcellular response to interferon-beta
D0038166biological_processangiotensin-activated signaling pathway
D0042802molecular_functionidentical protein binding
D0042803molecular_functionprotein homodimerization activity
D0043005cellular_componentneuron projection
D0043025cellular_componentneuronal cell body
D0043197cellular_componentdendritic spine
D0043226cellular_componentorganelle
D0045202cellular_componentsynapse
D0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
D0046777biological_processprotein autophosphorylation
D0046872molecular_functionmetal ion binding
D0046928biological_processregulation of neurotransmitter secretion
D0048168biological_processregulation of neuronal synaptic plasticity
D0048813biological_processdendrite morphogenesis
D0051346biological_processnegative regulation of hydrolase activity
D0051928biological_processpositive regulation of calcium ion transport
D0060996biological_processdendritic spine development
D0071346biological_processcellular response to type II interferon
D0098685cellular_componentSchaffer collateral - CA1 synapse
D0098696biological_processregulation of neurotransmitter receptor localization to postsynaptic specialization membrane
D0098877biological_processneurotransmitter receptor transport to plasma membrane
D0098978cellular_componentglutamatergic synapse
D0099148biological_processregulation of synaptic vesicle docking
D0099523cellular_componentpresynaptic cytosol
D0099524cellular_componentpostsynaptic cytosol
D0106310molecular_functionprotein serine kinase activity
D0110076biological_processnegative regulation of ferroptosis
D1902108biological_processregulation of mitochondrial membrane permeability involved in apoptotic process
D1903076biological_processregulation of protein localization to plasma membrane
D1990443biological_processpeptidyl-threonine autophosphorylation
D2000124biological_processregulation of endocannabinoid signaling pathway
D2001222biological_processregulation of neuron migration
E0000082biological_processG1/S transition of mitotic cell cycle
E0000166molecular_functionnucleotide binding
E0002931biological_processresponse to ischemia
E0004672molecular_functionprotein kinase activity
E0004674molecular_functionprotein serine/threonine kinase activity
E0004683molecular_functioncalcium/calmodulin-dependent protein kinase activity
E0005515molecular_functionprotein binding
E0005516molecular_functioncalmodulin binding
E0005524molecular_functionATP binding
E0005737cellular_componentcytoplasm
E0005739cellular_componentmitochondrion
E0005829cellular_componentcytosol
E0005954cellular_componentcalcium- and calmodulin-dependent protein kinase complex
E0006468biological_processprotein phosphorylation
E0006816biological_processcalcium ion transport
E0010666biological_processpositive regulation of cardiac muscle cell apoptotic process
E0014069cellular_componentpostsynaptic density
E0016301molecular_functionkinase activity
E0016740molecular_functiontransferase activity
E0018105biological_processpeptidyl-serine phosphorylation
E0030424cellular_componentaxon
E0030425cellular_componentdendrite
E0032794molecular_functionGTPase activating protein binding
E0032839cellular_componentdendrite cytoplasm
E0035235biological_processionotropic glutamate receptor signaling pathway
E0035254molecular_functionglutamate receptor binding
E0035458biological_processcellular response to interferon-beta
E0038166biological_processangiotensin-activated signaling pathway
E0042802molecular_functionidentical protein binding
E0042803molecular_functionprotein homodimerization activity
E0043005cellular_componentneuron projection
E0043025cellular_componentneuronal cell body
E0043197cellular_componentdendritic spine
E0043226cellular_componentorganelle
E0045202cellular_componentsynapse
E0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
E0046777biological_processprotein autophosphorylation
E0046872molecular_functionmetal ion binding
E0046928biological_processregulation of neurotransmitter secretion
E0048168biological_processregulation of neuronal synaptic plasticity
E0048813biological_processdendrite morphogenesis
E0051346biological_processnegative regulation of hydrolase activity
E0051928biological_processpositive regulation of calcium ion transport
E0060996biological_processdendritic spine development
E0071346biological_processcellular response to type II interferon
E0098685cellular_componentSchaffer collateral - CA1 synapse
E0098696biological_processregulation of neurotransmitter receptor localization to postsynaptic specialization membrane
E0098877biological_processneurotransmitter receptor transport to plasma membrane
E0098978cellular_componentglutamatergic synapse
E0099148biological_processregulation of synaptic vesicle docking
E0099523cellular_componentpresynaptic cytosol
E0099524cellular_componentpostsynaptic cytosol
E0106310molecular_functionprotein serine kinase activity
E0110076biological_processnegative regulation of ferroptosis
E1902108biological_processregulation of mitochondrial membrane permeability involved in apoptotic process
E1903076biological_processregulation of protein localization to plasma membrane
E1990443biological_processpeptidyl-threonine autophosphorylation
E2000124biological_processregulation of endocannabinoid signaling pathway
E2001222biological_processregulation of neuron migration
F0000082biological_processG1/S transition of mitotic cell cycle
F0000166molecular_functionnucleotide binding
F0002931biological_processresponse to ischemia
F0004672molecular_functionprotein kinase activity
F0004674molecular_functionprotein serine/threonine kinase activity
F0004683molecular_functioncalcium/calmodulin-dependent protein kinase activity
F0005515molecular_functionprotein binding
F0005516molecular_functioncalmodulin binding
F0005524molecular_functionATP binding
F0005737cellular_componentcytoplasm
F0005739cellular_componentmitochondrion
F0005829cellular_componentcytosol
F0005954cellular_componentcalcium- and calmodulin-dependent protein kinase complex
F0006468biological_processprotein phosphorylation
F0006816biological_processcalcium ion transport
F0010666biological_processpositive regulation of cardiac muscle cell apoptotic process
F0014069cellular_componentpostsynaptic density
F0016301molecular_functionkinase activity
F0016740molecular_functiontransferase activity
F0018105biological_processpeptidyl-serine phosphorylation
F0030424cellular_componentaxon
F0030425cellular_componentdendrite
F0032794molecular_functionGTPase activating protein binding
F0032839cellular_componentdendrite cytoplasm
F0035235biological_processionotropic glutamate receptor signaling pathway
F0035254molecular_functionglutamate receptor binding
F0035458biological_processcellular response to interferon-beta
F0038166biological_processangiotensin-activated signaling pathway
F0042802molecular_functionidentical protein binding
F0042803molecular_functionprotein homodimerization activity
F0043005cellular_componentneuron projection
F0043025cellular_componentneuronal cell body
F0043197cellular_componentdendritic spine
F0043226cellular_componentorganelle
F0045202cellular_componentsynapse
F0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
F0046777biological_processprotein autophosphorylation
F0046872molecular_functionmetal ion binding
F0046928biological_processregulation of neurotransmitter secretion
F0048168biological_processregulation of neuronal synaptic plasticity
F0048813biological_processdendrite morphogenesis
F0051346biological_processnegative regulation of hydrolase activity
F0051928biological_processpositive regulation of calcium ion transport
F0060996biological_processdendritic spine development
F0071346biological_processcellular response to type II interferon
F0098685cellular_componentSchaffer collateral - CA1 synapse
F0098696biological_processregulation of neurotransmitter receptor localization to postsynaptic specialization membrane
F0098877biological_processneurotransmitter receptor transport to plasma membrane
F0098978cellular_componentglutamatergic synapse
F0099148biological_processregulation of synaptic vesicle docking
F0099523cellular_componentpresynaptic cytosol
F0099524cellular_componentpostsynaptic cytosol
F0106310molecular_functionprotein serine kinase activity
F0110076biological_processnegative regulation of ferroptosis
F1902108biological_processregulation of mitochondrial membrane permeability involved in apoptotic process
F1903076biological_processregulation of protein localization to plasma membrane
F1990443biological_processpeptidyl-threonine autophosphorylation
F2000124biological_processregulation of endocannabinoid signaling pathway
F2001222biological_processregulation of neuron migration
G0000082biological_processG1/S transition of mitotic cell cycle
G0000166molecular_functionnucleotide binding
G0002931biological_processresponse to ischemia
G0004672molecular_functionprotein kinase activity
G0004674molecular_functionprotein serine/threonine kinase activity
G0004683molecular_functioncalcium/calmodulin-dependent protein kinase activity
G0005515molecular_functionprotein binding
G0005516molecular_functioncalmodulin binding
G0005524molecular_functionATP binding
G0005737cellular_componentcytoplasm
G0005739cellular_componentmitochondrion
G0005829cellular_componentcytosol
G0005954cellular_componentcalcium- and calmodulin-dependent protein kinase complex
G0006468biological_processprotein phosphorylation
G0006816biological_processcalcium ion transport
G0010666biological_processpositive regulation of cardiac muscle cell apoptotic process
G0014069cellular_componentpostsynaptic density
G0016301molecular_functionkinase activity
G0016740molecular_functiontransferase activity
G0018105biological_processpeptidyl-serine phosphorylation
G0030424cellular_componentaxon
G0030425cellular_componentdendrite
G0032794molecular_functionGTPase activating protein binding
G0032839cellular_componentdendrite cytoplasm
G0035235biological_processionotropic glutamate receptor signaling pathway
G0035254molecular_functionglutamate receptor binding
G0035458biological_processcellular response to interferon-beta
G0038166biological_processangiotensin-activated signaling pathway
G0042802molecular_functionidentical protein binding
G0042803molecular_functionprotein homodimerization activity
G0043005cellular_componentneuron projection
G0043025cellular_componentneuronal cell body
G0043197cellular_componentdendritic spine
G0043226cellular_componentorganelle
G0045202cellular_componentsynapse
G0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
G0046777biological_processprotein autophosphorylation
G0046872molecular_functionmetal ion binding
G0046928biological_processregulation of neurotransmitter secretion
G0048168biological_processregulation of neuronal synaptic plasticity
G0048813biological_processdendrite morphogenesis
G0051346biological_processnegative regulation of hydrolase activity
G0051928biological_processpositive regulation of calcium ion transport
G0060996biological_processdendritic spine development
G0071346biological_processcellular response to type II interferon
G0098685cellular_componentSchaffer collateral - CA1 synapse
G0098696biological_processregulation of neurotransmitter receptor localization to postsynaptic specialization membrane
G0098877biological_processneurotransmitter receptor transport to plasma membrane
G0098978cellular_componentglutamatergic synapse
G0099148biological_processregulation of synaptic vesicle docking
G0099523cellular_componentpresynaptic cytosol
G0099524cellular_componentpostsynaptic cytosol
G0106310molecular_functionprotein serine kinase activity
G0110076biological_processnegative regulation of ferroptosis
G1902108biological_processregulation of mitochondrial membrane permeability involved in apoptotic process
G1903076biological_processregulation of protein localization to plasma membrane
G1990443biological_processpeptidyl-threonine autophosphorylation
G2000124biological_processregulation of endocannabinoid signaling pathway
G2001222biological_processregulation of neuron migration
H0000082biological_processG1/S transition of mitotic cell cycle
H0000166molecular_functionnucleotide binding
H0002931biological_processresponse to ischemia
H0004672molecular_functionprotein kinase activity
H0004674molecular_functionprotein serine/threonine kinase activity
H0004683molecular_functioncalcium/calmodulin-dependent protein kinase activity
H0005515molecular_functionprotein binding
H0005516molecular_functioncalmodulin binding
H0005524molecular_functionATP binding
H0005737cellular_componentcytoplasm
H0005739cellular_componentmitochondrion
H0005829cellular_componentcytosol
H0005954cellular_componentcalcium- and calmodulin-dependent protein kinase complex
H0006468biological_processprotein phosphorylation
H0006816biological_processcalcium ion transport
H0010666biological_processpositive regulation of cardiac muscle cell apoptotic process
H0014069cellular_componentpostsynaptic density
H0016301molecular_functionkinase activity
H0016740molecular_functiontransferase activity
H0018105biological_processpeptidyl-serine phosphorylation
H0030424cellular_componentaxon
H0030425cellular_componentdendrite
H0032794molecular_functionGTPase activating protein binding
H0032839cellular_componentdendrite cytoplasm
H0035235biological_processionotropic glutamate receptor signaling pathway
H0035254molecular_functionglutamate receptor binding
H0035458biological_processcellular response to interferon-beta
H0038166biological_processangiotensin-activated signaling pathway
H0042802molecular_functionidentical protein binding
H0042803molecular_functionprotein homodimerization activity
H0043005cellular_componentneuron projection
H0043025cellular_componentneuronal cell body
H0043197cellular_componentdendritic spine
H0043226cellular_componentorganelle
H0045202cellular_componentsynapse
H0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
H0046777biological_processprotein autophosphorylation
H0046872molecular_functionmetal ion binding
H0046928biological_processregulation of neurotransmitter secretion
H0048168biological_processregulation of neuronal synaptic plasticity
H0048813biological_processdendrite morphogenesis
H0051346biological_processnegative regulation of hydrolase activity
H0051928biological_processpositive regulation of calcium ion transport
H0060996biological_processdendritic spine development
H0071346biological_processcellular response to type II interferon
H0098685cellular_componentSchaffer collateral - CA1 synapse
H0098696biological_processregulation of neurotransmitter receptor localization to postsynaptic specialization membrane
H0098877biological_processneurotransmitter receptor transport to plasma membrane
H0098978cellular_componentglutamatergic synapse
H0099148biological_processregulation of synaptic vesicle docking
H0099523cellular_componentpresynaptic cytosol
H0099524cellular_componentpostsynaptic cytosol
H0106310molecular_functionprotein serine kinase activity
H0110076biological_processnegative regulation of ferroptosis
H1902108biological_processregulation of mitochondrial membrane permeability involved in apoptotic process
H1903076biological_processregulation of protein localization to plasma membrane
H1990443biological_processpeptidyl-threonine autophosphorylation
H2000124biological_processregulation of endocannabinoid signaling pathway
H2001222biological_processregulation of neuron migration
I0000082biological_processG1/S transition of mitotic cell cycle
I0000166molecular_functionnucleotide binding
I0002931biological_processresponse to ischemia
I0004672molecular_functionprotein kinase activity
I0004674molecular_functionprotein serine/threonine kinase activity
I0004683molecular_functioncalcium/calmodulin-dependent protein kinase activity
I0005515molecular_functionprotein binding
I0005516molecular_functioncalmodulin binding
I0005524molecular_functionATP binding
I0005737cellular_componentcytoplasm
I0005739cellular_componentmitochondrion
I0005829cellular_componentcytosol
I0005954cellular_componentcalcium- and calmodulin-dependent protein kinase complex
I0006468biological_processprotein phosphorylation
I0006816biological_processcalcium ion transport
I0010666biological_processpositive regulation of cardiac muscle cell apoptotic process
I0014069cellular_componentpostsynaptic density
I0016301molecular_functionkinase activity
I0016740molecular_functiontransferase activity
I0018105biological_processpeptidyl-serine phosphorylation
I0030424cellular_componentaxon
I0030425cellular_componentdendrite
I0032794molecular_functionGTPase activating protein binding
I0032839cellular_componentdendrite cytoplasm
I0035235biological_processionotropic glutamate receptor signaling pathway
I0035254molecular_functionglutamate receptor binding
I0035458biological_processcellular response to interferon-beta
I0038166biological_processangiotensin-activated signaling pathway
I0042802molecular_functionidentical protein binding
I0042803molecular_functionprotein homodimerization activity
I0043005cellular_componentneuron projection
I0043025cellular_componentneuronal cell body
I0043197cellular_componentdendritic spine
I0043226cellular_componentorganelle
I0045202cellular_componentsynapse
I0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
I0046777biological_processprotein autophosphorylation
I0046872molecular_functionmetal ion binding
I0046928biological_processregulation of neurotransmitter secretion
I0048168biological_processregulation of neuronal synaptic plasticity
I0048813biological_processdendrite morphogenesis
I0051346biological_processnegative regulation of hydrolase activity
I0051928biological_processpositive regulation of calcium ion transport
I0060996biological_processdendritic spine development
I0071346biological_processcellular response to type II interferon
I0098685cellular_componentSchaffer collateral - CA1 synapse
I0098696biological_processregulation of neurotransmitter receptor localization to postsynaptic specialization membrane
I0098877biological_processneurotransmitter receptor transport to plasma membrane
I0098978cellular_componentglutamatergic synapse
I0099148biological_processregulation of synaptic vesicle docking
I0099523cellular_componentpresynaptic cytosol
I0099524cellular_componentpostsynaptic cytosol
I0106310molecular_functionprotein serine kinase activity
I0110076biological_processnegative regulation of ferroptosis
I1902108biological_processregulation of mitochondrial membrane permeability involved in apoptotic process
I1903076biological_processregulation of protein localization to plasma membrane
I1990443biological_processpeptidyl-threonine autophosphorylation
I2000124biological_processregulation of endocannabinoid signaling pathway
I2001222biological_processregulation of neuron migration
J0000082biological_processG1/S transition of mitotic cell cycle
J0000166molecular_functionnucleotide binding
J0002931biological_processresponse to ischemia
J0004672molecular_functionprotein kinase activity
J0004674molecular_functionprotein serine/threonine kinase activity
J0004683molecular_functioncalcium/calmodulin-dependent protein kinase activity
J0005515molecular_functionprotein binding
J0005516molecular_functioncalmodulin binding
J0005524molecular_functionATP binding
J0005737cellular_componentcytoplasm
J0005739cellular_componentmitochondrion
J0005829cellular_componentcytosol
J0005954cellular_componentcalcium- and calmodulin-dependent protein kinase complex
J0006468biological_processprotein phosphorylation
J0006816biological_processcalcium ion transport
J0010666biological_processpositive regulation of cardiac muscle cell apoptotic process
J0014069cellular_componentpostsynaptic density
J0016301molecular_functionkinase activity
J0016740molecular_functiontransferase activity
J0018105biological_processpeptidyl-serine phosphorylation
J0030424cellular_componentaxon
J0030425cellular_componentdendrite
J0032794molecular_functionGTPase activating protein binding
J0032839cellular_componentdendrite cytoplasm
J0035235biological_processionotropic glutamate receptor signaling pathway
J0035254molecular_functionglutamate receptor binding
J0035458biological_processcellular response to interferon-beta
J0038166biological_processangiotensin-activated signaling pathway
J0042802molecular_functionidentical protein binding
J0042803molecular_functionprotein homodimerization activity
J0043005cellular_componentneuron projection
J0043025cellular_componentneuronal cell body
J0043197cellular_componentdendritic spine
J0043226cellular_componentorganelle
J0045202cellular_componentsynapse
J0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
J0046777biological_processprotein autophosphorylation
J0046872molecular_functionmetal ion binding
J0046928biological_processregulation of neurotransmitter secretion
J0048168biological_processregulation of neuronal synaptic plasticity
J0048813biological_processdendrite morphogenesis
J0051346biological_processnegative regulation of hydrolase activity
J0051928biological_processpositive regulation of calcium ion transport
J0060996biological_processdendritic spine development
J0071346biological_processcellular response to type II interferon
J0098685cellular_componentSchaffer collateral - CA1 synapse
J0098696biological_processregulation of neurotransmitter receptor localization to postsynaptic specialization membrane
J0098877biological_processneurotransmitter receptor transport to plasma membrane
J0098978cellular_componentglutamatergic synapse
J0099148biological_processregulation of synaptic vesicle docking
J0099523cellular_componentpresynaptic cytosol
J0099524cellular_componentpostsynaptic cytosol
J0106310molecular_functionprotein serine kinase activity
J0110076biological_processnegative regulation of ferroptosis
J1902108biological_processregulation of mitochondrial membrane permeability involved in apoptotic process
J1903076biological_processregulation of protein localization to plasma membrane
J1990443biological_processpeptidyl-threonine autophosphorylation
J2000124biological_processregulation of endocannabinoid signaling pathway
J2001222biological_processregulation of neuron migration
K0000082biological_processG1/S transition of mitotic cell cycle
K0000166molecular_functionnucleotide binding
K0002931biological_processresponse to ischemia
K0004672molecular_functionprotein kinase activity
K0004674molecular_functionprotein serine/threonine kinase activity
K0004683molecular_functioncalcium/calmodulin-dependent protein kinase activity
K0005515molecular_functionprotein binding
K0005516molecular_functioncalmodulin binding
K0005524molecular_functionATP binding
K0005737cellular_componentcytoplasm
K0005739cellular_componentmitochondrion
K0005829cellular_componentcytosol
K0005954cellular_componentcalcium- and calmodulin-dependent protein kinase complex
K0006468biological_processprotein phosphorylation
K0006816biological_processcalcium ion transport
K0010666biological_processpositive regulation of cardiac muscle cell apoptotic process
K0014069cellular_componentpostsynaptic density
K0016301molecular_functionkinase activity
K0016740molecular_functiontransferase activity
K0018105biological_processpeptidyl-serine phosphorylation
K0030424cellular_componentaxon
K0030425cellular_componentdendrite
K0032794molecular_functionGTPase activating protein binding
K0032839cellular_componentdendrite cytoplasm
K0035235biological_processionotropic glutamate receptor signaling pathway
K0035254molecular_functionglutamate receptor binding
K0035458biological_processcellular response to interferon-beta
K0038166biological_processangiotensin-activated signaling pathway
K0042802molecular_functionidentical protein binding
K0042803molecular_functionprotein homodimerization activity
K0043005cellular_componentneuron projection
K0043025cellular_componentneuronal cell body
K0043197cellular_componentdendritic spine
K0043226cellular_componentorganelle
K0045202cellular_componentsynapse
K0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
K0046777biological_processprotein autophosphorylation
K0046872molecular_functionmetal ion binding
K0046928biological_processregulation of neurotransmitter secretion
K0048168biological_processregulation of neuronal synaptic plasticity
K0048813biological_processdendrite morphogenesis
K0051346biological_processnegative regulation of hydrolase activity
K0051928biological_processpositive regulation of calcium ion transport
K0060996biological_processdendritic spine development
K0071346biological_processcellular response to type II interferon
K0098685cellular_componentSchaffer collateral - CA1 synapse
K0098696biological_processregulation of neurotransmitter receptor localization to postsynaptic specialization membrane
K0098877biological_processneurotransmitter receptor transport to plasma membrane
K0098978cellular_componentglutamatergic synapse
K0099148biological_processregulation of synaptic vesicle docking
K0099523cellular_componentpresynaptic cytosol
K0099524cellular_componentpostsynaptic cytosol
K0106310molecular_functionprotein serine kinase activity
K0110076biological_processnegative regulation of ferroptosis
K1902108biological_processregulation of mitochondrial membrane permeability involved in apoptotic process
K1903076biological_processregulation of protein localization to plasma membrane
K1990443biological_processpeptidyl-threonine autophosphorylation
K2000124biological_processregulation of endocannabinoid signaling pathway
K2001222biological_processregulation of neuron migration
L0000082biological_processG1/S transition of mitotic cell cycle
L0000166molecular_functionnucleotide binding
L0002931biological_processresponse to ischemia
L0004672molecular_functionprotein kinase activity
L0004674molecular_functionprotein serine/threonine kinase activity
L0004683molecular_functioncalcium/calmodulin-dependent protein kinase activity
L0005515molecular_functionprotein binding
L0005516molecular_functioncalmodulin binding
L0005524molecular_functionATP binding
L0005737cellular_componentcytoplasm
L0005739cellular_componentmitochondrion
L0005829cellular_componentcytosol
L0005954cellular_componentcalcium- and calmodulin-dependent protein kinase complex
L0006468biological_processprotein phosphorylation
L0006816biological_processcalcium ion transport
L0010666biological_processpositive regulation of cardiac muscle cell apoptotic process
L0014069cellular_componentpostsynaptic density
L0016301molecular_functionkinase activity
L0016740molecular_functiontransferase activity
L0018105biological_processpeptidyl-serine phosphorylation
L0030424cellular_componentaxon
L0030425cellular_componentdendrite
L0032794molecular_functionGTPase activating protein binding
L0032839cellular_componentdendrite cytoplasm
L0035235biological_processionotropic glutamate receptor signaling pathway
L0035254molecular_functionglutamate receptor binding
L0035458biological_processcellular response to interferon-beta
L0038166biological_processangiotensin-activated signaling pathway
L0042802molecular_functionidentical protein binding
L0042803molecular_functionprotein homodimerization activity
L0043005cellular_componentneuron projection
L0043025cellular_componentneuronal cell body
L0043197cellular_componentdendritic spine
L0043226cellular_componentorganelle
L0045202cellular_componentsynapse
L0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
L0046777biological_processprotein autophosphorylation
L0046872molecular_functionmetal ion binding
L0046928biological_processregulation of neurotransmitter secretion
L0048168biological_processregulation of neuronal synaptic plasticity
L0048813biological_processdendrite morphogenesis
L0051346biological_processnegative regulation of hydrolase activity
L0051928biological_processpositive regulation of calcium ion transport
L0060996biological_processdendritic spine development
L0071346biological_processcellular response to type II interferon
L0098685cellular_componentSchaffer collateral - CA1 synapse
L0098696biological_processregulation of neurotransmitter receptor localization to postsynaptic specialization membrane
L0098877biological_processneurotransmitter receptor transport to plasma membrane
L0098978cellular_componentglutamatergic synapse
L0099148biological_processregulation of synaptic vesicle docking
L0099523cellular_componentpresynaptic cytosol
L0099524cellular_componentpostsynaptic cytosol
L0106310molecular_functionprotein serine kinase activity
L0110076biological_processnegative regulation of ferroptosis
L1902108biological_processregulation of mitochondrial membrane permeability involved in apoptotic process
L1903076biological_processregulation of protein localization to plasma membrane
L1990443biological_processpeptidyl-threonine autophosphorylation
L2000124biological_processregulation of endocannabinoid signaling pathway
L2001222biological_processregulation of neuron migration
Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues24
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGKGAFSVVRrCvkvlagqe..........YAAK
ChainResidueDetails
ALEU19-LYS42

site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VvHrDLKpeNLLL
ChainResidueDetails
AVAL131-LEU143

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3096
DetailsDomain: {"description":"Protein kinase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues120
DetailsRegion: {"description":"Calmodulin-binding"}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues120
DetailsRegion: {"description":"Interaction with BAALC","evidences":[{"source":"PubMed","id":"15659234","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues324
DetailsRegion: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues108
DetailsCompositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues12
DetailsActive site: {"description":"Proton acceptor"}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues108
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues12
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P11798","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI9
Number of Residues24
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"22673903","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI10
Number of Residues12
DetailsModified residue: {"description":"Phosphothreonine; by autocatalysis","evidences":[{"source":"PubMed","id":"2842767","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI11
Number of Residues36
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P11798","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI12
Number of Residues24
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P11798","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

247536

PDB entries from 2026-01-14

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