Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5U6G

Crystal Structure of the holo Domain-Swapped Dimer mutant Q108K:K40D Human Cellular Retinol Binding Protein II bound with all trans retinal

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005501	molecular_function	retinoid binding
A	0005504	molecular_function	fatty acid binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006776	biological_process	vitamin A metabolic process
A	0008289	molecular_function	lipid binding
A	0008544	biological_process	epidermis development
A	0015908	biological_process	fatty acid transport
A	0016918	molecular_function	retinal binding
A	0019841	molecular_function	retinol binding
B	0005501	molecular_function	retinoid binding
B	0005504	molecular_function	fatty acid binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006776	biological_process	vitamin A metabolic process
B	0008289	molecular_function	lipid binding
B	0008544	biological_process	epidermis development
B	0015908	biological_process	fatty acid transport
B	0016918	molecular_function	retinal binding
B	0019841	molecular_function	retinol binding
C	0005501	molecular_function	retinoid binding
C	0005504	molecular_function	fatty acid binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006776	biological_process	vitamin A metabolic process
C	0008289	molecular_function	lipid binding
C	0008544	biological_process	epidermis development
C	0015908	biological_process	fatty acid transport
C	0016918	molecular_function	retinal binding
C	0019841	molecular_function	retinol binding
D	0005501	molecular_function	retinoid binding
D	0005504	molecular_function	fatty acid binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006776	biological_process	vitamin A metabolic process
D	0008289	molecular_function	lipid binding
D	0008544	biological_process	epidermis development
D	0015908	biological_process	fatty acid transport
D	0016918	molecular_function	retinal binding
D	0019841	molecular_function	retinol binding
E	0005501	molecular_function	retinoid binding
E	0005504	molecular_function	fatty acid binding
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006776	biological_process	vitamin A metabolic process
E	0008289	molecular_function	lipid binding
E	0008544	biological_process	epidermis development
E	0015908	biological_process	fatty acid transport
E	0016918	molecular_function	retinal binding
E	0019841	molecular_function	retinol binding
F	0005501	molecular_function	retinoid binding
F	0005504	molecular_function	fatty acid binding
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006776	biological_process	vitamin A metabolic process
F	0008289	molecular_function	lipid binding
F	0008544	biological_process	epidermis development
F	0015908	biological_process	fatty acid transport
F	0016918	molecular_function	retinal binding
F	0019841	molecular_function	retinol binding
G	0005501	molecular_function	retinoid binding
G	0005504	molecular_function	fatty acid binding
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006776	biological_process	vitamin A metabolic process
G	0008289	molecular_function	lipid binding
G	0008544	biological_process	epidermis development
G	0015908	biological_process	fatty acid transport
G	0016918	molecular_function	retinal binding
G	0019841	molecular_function	retinol binding
H	0005501	molecular_function	retinoid binding
H	0005504	molecular_function	fatty acid binding
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006776	biological_process	vitamin A metabolic process
H	0008289	molecular_function	lipid binding
H	0008544	biological_process	epidermis development
H	0015908	biological_process	fatty acid transport
H	0016918	molecular_function	retinal binding
H	0019841	molecular_function	retinol binding
I	0005501	molecular_function	retinoid binding
I	0005504	molecular_function	fatty acid binding
I	0005634	cellular_component	nucleus
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0006776	biological_process	vitamin A metabolic process
I	0008289	molecular_function	lipid binding
I	0008544	biological_process	epidermis development
I	0015908	biological_process	fatty acid transport
I	0016918	molecular_function	retinal binding
I	0019841	molecular_function	retinol binding
J	0005501	molecular_function	retinoid binding
J	0005504	molecular_function	fatty acid binding
J	0005634	cellular_component	nucleus
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0006776	biological_process	vitamin A metabolic process
J	0008289	molecular_function	lipid binding
J	0008544	biological_process	epidermis development
J	0015908	biological_process	fatty acid transport
J	0016918	molecular_function	retinal binding
J	0019841	molecular_function	retinol binding
K	0005501	molecular_function	retinoid binding
K	0005504	molecular_function	fatty acid binding
K	0005634	cellular_component	nucleus
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0006776	biological_process	vitamin A metabolic process
K	0008289	molecular_function	lipid binding
K	0008544	biological_process	epidermis development
K	0015908	biological_process	fatty acid transport
K	0016918	molecular_function	retinal binding
K	0019841	molecular_function	retinol binding
L	0005501	molecular_function	retinoid binding
L	0005504	molecular_function	fatty acid binding
L	0005634	cellular_component	nucleus
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0006776	biological_process	vitamin A metabolic process
L	0008289	molecular_function	lipid binding
L	0008544	biological_process	epidermis development
L	0015908	biological_process	fatty acid transport
L	0016918	molecular_function	retinal binding
L	0019841	molecular_function	retinol binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	binding site for residue RET A 201

Chain	Residue
A	TYR60
F	GLN38
A	LEU77
A	TRP106
A	LYS108
F	PHE16
F	TYR19
F	MET20
F	ILE25
F	ALA33

site_id	AC2
Number of Residues	7
Details	binding site for residue RET B 201

Chain	Residue
B	ARG58
B	TYR60
B	TRP106
B	LYS108
B	LEU117
E	PHE16
E	ALA33

site_id	AC3
Number of Residues	8
Details	binding site for residue RET D 201

Chain	Residue
D	ARG58
D	TYR60
D	LEU77
D	TRP106
D	LYS108
H	ILE25
H	ALA33
H	GLN38

site_id	AC4
Number of Residues	10
Details	binding site for residue RET F 201

Chain	Residue
A	PHE16
A	MET20
A	ALA33
A	GLN38
A	ASP40
F	LEU77
F	TRP106
F	LYS108
F	LEU117
F	LEU119

site_id	AC5
Number of Residues	8
Details	binding site for residue RET G 201

Chain	Residue
C	ILE25
C	ALA33
C	GLN38
G	ASN59
G	TYR60
G	TRP106
G	LYS108
G	LEU117

site_id	AC6
Number of Residues	12
Details	binding site for residue RET L 201

Chain	Residue
J	PHE16
J	TYR19
J	MET20
J	GLN38
J	ASP40
J	THR53
J	SER55
L	LEU77
L	TRP106
L	LYS108
L	LEU117
L	LEU119

Functional Information from PROSITE/UniProt

site_id	PS00214
Number of Residues	18
Details	FABP Cytosolic fatty-acid binding proteins signature. GTWeMesNeNFEgYMKAL

Chain	Residue	Details
A	GLY6-LEU23
G	GLY6-LEU23

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:18076076

Chain	Residue	Details
G	LYS40
H	LYS108
E	ASP40
E	LYS108
F	ASP40
F	LYS108
J	ASP40
J	LYS108
K	ASP40
K	LYS108
L	ASP40
G	LYS108
L	LYS108
I	LYS40
I	LYS108
C	ASP40
C	LYS108
D	ASP40
D	LYS108
H	ASP40

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)