5U1C

Structure of tetrameric HIV-1 Strand Transfer Complex Intasome

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0003677	molecular_function	DNA binding
A	0004521	molecular_function	RNA endonuclease activity
A	0008270	molecular_function	zinc ion binding
A	0015074	biological_process	DNA integration
B	0003676	molecular_function	nucleic acid binding
B	0003677	molecular_function	DNA binding
B	0004521	molecular_function	RNA endonuclease activity
B	0008270	molecular_function	zinc ion binding
B	0015074	biological_process	DNA integration
C	0003676	molecular_function	nucleic acid binding
C	0003677	molecular_function	DNA binding
C	0004521	molecular_function	RNA endonuclease activity
C	0008270	molecular_function	zinc ion binding
C	0015074	biological_process	DNA integration
D	0003676	molecular_function	nucleic acid binding
D	0003677	molecular_function	DNA binding
D	0004521	molecular_function	RNA endonuclease activity
D	0008270	molecular_function	zinc ion binding
D	0015074	biological_process	DNA integration

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 500

Chain	Residue
A	HIS12
A	HIS16
A	CYS40
A	CYS43

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site_id	AC2
Number of Residues	4
Details	binding site for residue MG A 501

Chain	Residue
A	ASP64
A	ASP116
G	DT11
J	DG22

---

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN C 500

Chain	Residue
C	HIS16
C	CYS40
C	CYS43
C	HIS12

---

site_id	AC4
Number of Residues	4
Details	binding site for residue MG C 501

Chain	Residue
C	ASP64
C	ASP116
F	DG22
H	DT11

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	164
Details	ZN_FING: Integrase-type => ECO:0000255|PROSITE-ProRule:PRU00450

Chain	Residue	Details
A	ASP3-GLN44
B	ASP3-GLN44
C	ASP3-GLN44
D	ASP3-GLN44

---

site_id	SWS_FT_FI2
Number of Residues	188
Details	DNA_BIND: Integrase-type => ECO:0000255|PROSITE-ProRule:PRU00506

Chain	Residue	Details
A	PHE223-ASP270
B	PHE223-ASP270
C	PHE223-ASP270
D	PHE223-ASP270

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	LYS-11
B	LYS-11
C	LYS-11
D	LYS-11

---

site_id	SWS_FT_FI4
Number of Residues	16
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00450

Chain	Residue	Details
A	HIS12
C	HIS16
C	CYS40
C	CYS43
D	HIS12
D	HIS16
D	CYS40
D	CYS43
A	HIS16
A	CYS40
A	CYS43
B	HIS12
B	HIS16
B	CYS40
B	CYS43
C	HIS12

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	BINDING:

Chain	Residue	Details
A	ASP64
A	ASP116
B	ASP64
B	ASP116
C	ASP64
C	ASP116
D	ASP64
D	ASP116

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P04585

Chain	Residue	Details
A	GLN152
B	GLN152
C	GLN152
D	GLN152

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