Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5U03

Cryo-EM structure of the human CTP synthase filament

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000785	cellular_component	chromatin
A	0002376	biological_process	immune system process
A	0003883	molecular_function	CTP synthase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005694	cellular_component	chromosome
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006139	biological_process	nucleobase-containing compound metabolic process
A	0006221	biological_process	pyrimidine nucleotide biosynthetic process
A	0006241	biological_process	CTP biosynthetic process
A	0006325	biological_process	chromatin organization
A	0006974	biological_process	DNA damage response
A	0009410	biological_process	response to xenobiotic stimulus
A	0016020	cellular_component	membrane
A	0016787	molecular_function	hydrolase activity
A	0016874	molecular_function	ligase activity
A	0019856	biological_process	pyrimidine nucleobase biosynthetic process
A	0032480	biological_process	negative regulation of type I interferon production
A	0042098	biological_process	T cell proliferation
A	0042100	biological_process	B cell proliferation
A	0042802	molecular_function	identical protein binding
A	0044210	biological_process	'de novo' CTP biosynthetic process
A	0044281	biological_process	small molecule metabolic process
A	0097268	cellular_component	cytoophidium
A	0140861	biological_process	DNA repair-dependent chromatin remodeling
A	0160260	molecular_function	protein asparagine deamidase activity
A	0160264	molecular_function	histone H1N76/N77 asparagine deamidase activity
A	1902340	biological_process	negative regulation of chromosome condensation
B	0000166	molecular_function	nucleotide binding
B	0000785	cellular_component	chromatin
B	0002376	biological_process	immune system process
B	0003883	molecular_function	CTP synthase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005694	cellular_component	chromosome
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006139	biological_process	nucleobase-containing compound metabolic process
B	0006221	biological_process	pyrimidine nucleotide biosynthetic process
B	0006241	biological_process	CTP biosynthetic process
B	0006325	biological_process	chromatin organization
B	0006974	biological_process	DNA damage response
B	0009410	biological_process	response to xenobiotic stimulus
B	0016020	cellular_component	membrane
B	0016787	molecular_function	hydrolase activity
B	0016874	molecular_function	ligase activity
B	0019856	biological_process	pyrimidine nucleobase biosynthetic process
B	0032480	biological_process	negative regulation of type I interferon production
B	0042098	biological_process	T cell proliferation
B	0042100	biological_process	B cell proliferation
B	0042802	molecular_function	identical protein binding
B	0044210	biological_process	'de novo' CTP biosynthetic process
B	0044281	biological_process	small molecule metabolic process
B	0097268	cellular_component	cytoophidium
B	0140861	biological_process	DNA repair-dependent chromatin remodeling
B	0160260	molecular_function	protein asparagine deamidase activity
B	0160264	molecular_function	histone H1N76/N77 asparagine deamidase activity
B	1902340	biological_process	negative regulation of chromosome condensation
C	0000166	molecular_function	nucleotide binding
C	0000785	cellular_component	chromatin
C	0002376	biological_process	immune system process
C	0003883	molecular_function	CTP synthase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005634	cellular_component	nucleus
C	0005694	cellular_component	chromosome
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006139	biological_process	nucleobase-containing compound metabolic process
C	0006221	biological_process	pyrimidine nucleotide biosynthetic process
C	0006241	biological_process	CTP biosynthetic process
C	0006325	biological_process	chromatin organization
C	0006974	biological_process	DNA damage response
C	0009410	biological_process	response to xenobiotic stimulus
C	0016020	cellular_component	membrane
C	0016787	molecular_function	hydrolase activity
C	0016874	molecular_function	ligase activity
C	0019856	biological_process	pyrimidine nucleobase biosynthetic process
C	0032480	biological_process	negative regulation of type I interferon production
C	0042098	biological_process	T cell proliferation
C	0042100	biological_process	B cell proliferation
C	0042802	molecular_function	identical protein binding
C	0044210	biological_process	'de novo' CTP biosynthetic process
C	0044281	biological_process	small molecule metabolic process
C	0097268	cellular_component	cytoophidium
C	0140861	biological_process	DNA repair-dependent chromatin remodeling
C	0160260	molecular_function	protein asparagine deamidase activity
C	0160264	molecular_function	histone H1N76/N77 asparagine deamidase activity
C	1902340	biological_process	negative regulation of chromosome condensation
D	0000166	molecular_function	nucleotide binding
D	0000785	cellular_component	chromatin
D	0002376	biological_process	immune system process
D	0003883	molecular_function	CTP synthase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005634	cellular_component	nucleus
D	0005694	cellular_component	chromosome
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006139	biological_process	nucleobase-containing compound metabolic process
D	0006221	biological_process	pyrimidine nucleotide biosynthetic process
D	0006241	biological_process	CTP biosynthetic process
D	0006325	biological_process	chromatin organization
D	0006974	biological_process	DNA damage response
D	0009410	biological_process	response to xenobiotic stimulus
D	0016020	cellular_component	membrane
D	0016787	molecular_function	hydrolase activity
D	0016874	molecular_function	ligase activity
D	0019856	biological_process	pyrimidine nucleobase biosynthetic process
D	0032480	biological_process	negative regulation of type I interferon production
D	0042098	biological_process	T cell proliferation
D	0042100	biological_process	B cell proliferation
D	0042802	molecular_function	identical protein binding
D	0044210	biological_process	'de novo' CTP biosynthetic process
D	0044281	biological_process	small molecule metabolic process
D	0097268	cellular_component	cytoophidium
D	0140861	biological_process	DNA repair-dependent chromatin remodeling
D	0160260	molecular_function	protein asparagine deamidase activity
D	0160264	molecular_function	histone H1N76/N77 asparagine deamidase activity
D	1902340	biological_process	negative regulation of chromosome condensation

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	binding site for residue ATP A 601

Chain	Residue
A	GLY13
A	VAL247
A	ASP312
A	UTP602
A	ILE14
A	GLY15
A	LYS16
A	GLY17
A	ILE18
A	ASP70
A	GLU146
A	ARG217

site_id	AC2
Number of Residues	16
Details	binding site for residue UTP A 602

Chain	Residue
A	SER12
A	LYS38
A	ASP40
A	PRO41
A	TYR42
A	GLU146
A	GLY148
A	GLY149
A	GLU155
A	ATP601
B	LYS193
B	THR194
B	LYS195
B	GLN198
B	PHE233
C	GLN112

site_id	AC3
Number of Residues	12
Details	binding site for residue ATP B 601

Chain	Residue
B	GLY13
B	ILE14
B	GLY15
B	LYS16
B	GLY17
B	ILE18
B	ASP70
B	GLU146
B	ARG217
B	VAL247
B	ASP312
B	UTP602

site_id	AC4
Number of Residues	16
Details	binding site for residue UTP B 602

Chain	Residue
A	LYS193
A	THR194
A	LYS195
A	GLN198
A	PHE233
B	SER12
B	LYS38
B	ASP40
B	PRO41
B	TYR42
B	GLU146
B	GLY148
B	GLY149
B	GLU155
B	ATP601
D	GLN112

site_id	AC5
Number of Residues	12
Details	binding site for residue ATP C 601

Chain	Residue
C	GLY13
C	ILE14
C	GLY15
C	LYS16
C	GLY17
C	ILE18
C	ASP70
C	GLU146
C	ARG217
C	VAL247
C	ASP312
C	UTP602

site_id	AC6
Number of Residues	16
Details	binding site for residue UTP C 602

Chain	Residue
A	GLN112
C	SER12
C	LYS38
C	ASP40
C	PRO41
C	TYR42
C	GLU146
C	GLY148
C	GLY149
C	GLU155
C	ATP601
D	LYS193
D	THR194
D	LYS195
D	GLN198
D	PHE233

site_id	AC7
Number of Residues	12
Details	binding site for residue ATP D 601

Chain	Residue
D	GLY13
D	ILE14
D	GLY15
D	LYS16
D	GLY17
D	ILE18
D	ASP70
D	GLU146
D	ARG217
D	VAL247
D	ASP312
D	UTP602

site_id	AC8
Number of Residues	16
Details	binding site for residue UTP D 602

Chain	Residue
C	LYS195
C	GLN198
C	PHE233
D	SER12
D	LYS38
D	ASP40
D	PRO41
D	TYR42
D	GLU146
D	GLY148
D	GLY149
D	GLU155
D	ATP601
B	GLN112
C	LYS193
C	THR194

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1016
Details	Domain: {"description":"Glutamine amidotransferase type-1"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	12
Details	Active site: {"description":"For GATase activity","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)