5TYU

DNA Polymerase Mu Reactant Complex, Mn2+ (4 min)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003887	molecular_function	DNA-directed DNA polymerase activity
A	0005634	cellular_component	nucleus
A	0006281	biological_process	DNA repair
A	0016779	molecular_function	nucleotidyltransferase activity
A	0034061	molecular_function	DNA polymerase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	30
Details	binding site for residue TTP A 501

Chain	Residue
A	GLY319
A	TRP434
A	THR435
A	GLY436
A	LYS438
A	MN502
A	MN503
A	CA506
A	PPV507
A	HOH611
A	HOH625
A	GLY320
A	HOH664
A	HOH677
A	HOH696
A	HOH718
P	DA4
P	DT5
P	MN101
P	EDO102
P	HOH202
P	HOH212
A	ARG323
T	DA5
A	LYS325
A	GLY328
A	HIS329
A	ASP330
A	ASP332
A	GLY433

---

site_id	AC2
Number of Residues	8
Details	binding site for residue MN A 502

Chain	Residue
A	ASP330
A	ASP332
A	ASP418
A	TTP501
A	MN503
P	DA4
P	DT5
P	HOH202

---

site_id	AC3
Number of Residues	8
Details	binding site for residue MN A 503

Chain	Residue
A	ASP330
A	ASP332
A	TTP501
A	MN502
A	CA506
A	PPV507
A	HOH718
P	DT5

---

site_id	AC4
Number of Residues	2
Details	binding site for residue MN A 504

Chain	Residue
A	GLU218
A	HIS219

---

site_id	AC5
Number of Residues	6
Details	binding site for residue NA A 505

Chain	Residue
A	THR241
A	ILE243
A	VAL246
A	HOH773
P	DT3
P	HOH203

---

site_id	AC6
Number of Residues	8
Details	binding site for residue CA A 506

Chain	Residue
A	ASP330
A	ASP332
A	ASP418
A	TTP501
A	MN503
P	DA4
P	DT5
P	HOH202

---

site_id	AC7
Number of Residues	18
Details	binding site for residue PPV A 507

Chain	Residue
A	GLY319
A	GLY320
A	ARG323
A	LYS325
A	GLY328
A	HIS329
A	ASP330
A	ASP332
A	TTP501
A	MN503
A	HOH611
A	HOH625
A	HOH664
A	HOH677
A	HOH696
A	HOH718
P	DT5
P	MN101

---

site_id	AC8
Number of Residues	2
Details	binding site for residue DTT A 508

Chain	Residue
A	CYS180
A	HOH760

---

site_id	AC9
Number of Residues	7
Details	binding site for residue EDO A 509

Chain	Residue
A	ARG253
A	ARG256
A	GLU451
A	LYS452
A	GLY453
A	HOH619
A	HOH673

---

site_id	AD1
Number of Residues	4
Details	binding site for residue EDO A 510

Chain	Residue
A	HIS152
A	THR314
A	THR336
A	HOH667

---

site_id	AD2
Number of Residues	5
Details	binding site for residue EPE A 511

Chain	Residue
A	LEU149
A	LYS325
A	LEU326
A	GLN327
A	HOH710

---

site_id	AD3
Number of Residues	5
Details	binding site for residue MN P 101

Chain	Residue
A	TTP501
A	PPV507
P	DT5
P	HOH212
A	HIS329

---

site_id	AD4
Number of Residues	7
Details	binding site for residue EDO P 102

Chain	Residue
A	ARG387
A	GLY433
A	TRP434
A	ARG445
A	TTP501
P	DA4
P	DT5

---

Functional Information from PROSITE/UniProt

site_id	PS00522
Number of Residues	20
Details	DNA_POLYMERASE_X DNA polymerase family X signature. GGFrRGklqGhDVDFLIthP

Chain	Residue	Details
A	GLY319-PRO338

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	9
Details	Region: {"description":"Involved in ssDNA binding","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Site: {"description":"Responsible for the low discrimination between dNTP and rNTP"}

Chain

Residue

Details

---