5TXT

Structure of asymmetric apo/holo ALAS dimer from S. cerevisiae

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003870	molecular_function	5-aminolevulinate synthase activity
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0006782	biological_process	protoporphyrinogen IX biosynthetic process
A	0006783	biological_process	heme biosynthetic process
A	0009058	biological_process	biosynthetic process
A	0016740	molecular_function	transferase activity
A	0016746	molecular_function	acyltransferase activity
A	0030170	molecular_function	pyridoxal phosphate binding
A	0033014	biological_process	tetrapyrrole biosynthetic process
A	1902117	biological_process	positive regulation of organelle assembly
B	0003870	molecular_function	5-aminolevulinate synthase activity
B	0005739	cellular_component	mitochondrion
B	0005759	cellular_component	mitochondrial matrix
B	0006782	biological_process	protoporphyrinogen IX biosynthetic process
B	0006783	biological_process	heme biosynthetic process
B	0009058	biological_process	biosynthetic process
B	0016740	molecular_function	transferase activity
B	0016746	molecular_function	acyltransferase activity
B	0030170	molecular_function	pyridoxal phosphate binding
B	0033014	biological_process	tetrapyrrole biosynthetic process
B	1902117	biological_process	positive regulation of organelle assembly
C	0003870	molecular_function	5-aminolevulinate synthase activity
C	0005739	cellular_component	mitochondrion
C	0005759	cellular_component	mitochondrial matrix
C	0006782	biological_process	protoporphyrinogen IX biosynthetic process
C	0006783	biological_process	heme biosynthetic process
C	0009058	biological_process	biosynthetic process
C	0016740	molecular_function	transferase activity
C	0016746	molecular_function	acyltransferase activity
C	0030170	molecular_function	pyridoxal phosphate binding
C	0033014	biological_process	tetrapyrrole biosynthetic process
C	1902117	biological_process	positive regulation of organelle assembly
D	0003870	molecular_function	5-aminolevulinate synthase activity
D	0005739	cellular_component	mitochondrion
D	0005759	cellular_component	mitochondrial matrix
D	0006782	biological_process	protoporphyrinogen IX biosynthetic process
D	0006783	biological_process	heme biosynthetic process
D	0009058	biological_process	biosynthetic process
D	0016740	molecular_function	transferase activity
D	0016746	molecular_function	acyltransferase activity
D	0030170	molecular_function	pyridoxal phosphate binding
D	0033014	biological_process	tetrapyrrole biosynthetic process
D	1902117	biological_process	positive regulation of organelle assembly
E	0003870	molecular_function	5-aminolevulinate synthase activity
E	0005739	cellular_component	mitochondrion
E	0005759	cellular_component	mitochondrial matrix
E	0006782	biological_process	protoporphyrinogen IX biosynthetic process
E	0006783	biological_process	heme biosynthetic process
E	0009058	biological_process	biosynthetic process
E	0016740	molecular_function	transferase activity
E	0016746	molecular_function	acyltransferase activity
E	0030170	molecular_function	pyridoxal phosphate binding
E	0033014	biological_process	tetrapyrrole biosynthetic process
E	1902117	biological_process	positive regulation of organelle assembly
F	0003870	molecular_function	5-aminolevulinate synthase activity
F	0005739	cellular_component	mitochondrion
F	0005759	cellular_component	mitochondrial matrix
F	0006782	biological_process	protoporphyrinogen IX biosynthetic process
F	0006783	biological_process	heme biosynthetic process
F	0009058	biological_process	biosynthetic process
F	0016740	molecular_function	transferase activity
F	0016746	molecular_function	acyltransferase activity
F	0030170	molecular_function	pyridoxal phosphate binding
F	0033014	biological_process	tetrapyrrole biosynthetic process
F	1902117	biological_process	positive regulation of organelle assembly

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue PE3 B 601

Chain	Residue
B	ASN439
B	LYS440
B	PE3602
B	PE3603
B	HOH716

---

site_id	AC2
Number of Residues	4
Details	binding site for residue PE3 B 602

Chain	Residue
B	ALA311
B	THR312
B	PE3601
B	PE3603

---

site_id	AC3
Number of Residues	3
Details	binding site for residue PE3 B 603

Chain	Residue
B	PE3601
B	PE3602
B	HOH742

---

site_id	AC4
Number of Residues	2
Details	binding site for residue SO4 D 601

Chain	Residue
D	SER256
D	HIS284

---

site_id	AC5
Number of Residues	6
Details	binding site for residue PE3 C 601

Chain	Residue
C	THR312
C	PE3602
C	PE3603
C	HOH756
C	HOH757
C	HOH758

---

site_id	AC6
Number of Residues	4
Details	binding site for residue PE3 C 602

Chain	Residue
C	ASN439
C	LYS440
C	PE3601
C	PE3603

---

site_id	AC7
Number of Residues	2
Details	binding site for residue PE3 C 603

Chain	Residue
C	PE3601
C	PE3602

---

site_id	AC8
Number of Residues	1
Details	binding site for residue PE3 F 601

Chain	Residue
F	THR312

---

Functional Information from PROSITE/UniProt

site_id	PS00599
Number of Residues	10
Details	AA_TRANSFER_CLASS_2 Aminotransferases class-II pyridoxal-phosphate attachment site. TLGKSFGSVG

Chain	Residue	Details
A	THR334-GLY343
B	THR334-GLY343

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: ACT_SITE => ECO:0000250|UniProtKB:P18079

Chain	Residue	Details
B	LLP337
C	LLP337
F	LLP337

---

site_id	SWS_FT_FI2
Number of Residues	18
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P18079

Chain	Residue	Details
F	ARG91
F	SER204
F	LYS223
F	THR366
F	THR367
F	THR452
B	ARG91
B	SER204
B	LYS223
B	THR366
B	THR367
B	THR452
C	ARG91
C	SER204
C	LYS223
C	THR366
C	THR367
C	THR452

---

site_id	SWS_FT_FI3
Number of Residues	9
Details	BINDING: in other chain => ECO:0000250|UniProtKB:P18079

Chain	Residue	Details
B	SER256
B	HIS284
B	THR334
C	SER256
C	HIS284
C	THR334
F	SER256
F	HIS284
F	THR334

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	MOD_RES: N6-(pyridoxal phosphate)lysine => ECO:0000250|UniProtKB:P18079

Chain	Residue	Details
B	LLP337
C	LLP337
F	LLP337

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