5TVC

Crystal structure of a chimeric acetylcholine binding protein from Aplysia californica (Ac-AChBP) containing loop C from the human alpha 3 nicotinic acetylcholine receptor in complex with (E,2S)-N-methyl-5-(5-phenoxy-3-pyridyl)pent-4-en-2-amine (TI-5312)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0005216	molecular_function	monoatomic ion channel activity
A	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
C	0004888	molecular_function	transmembrane signaling receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
D	0004888	molecular_function	transmembrane signaling receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
E	0004888	molecular_function	transmembrane signaling receptor activity
E	0005216	molecular_function	monoatomic ion channel activity
E	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
E	0006811	biological_process	monoatomic ion transport
E	0016020	cellular_component	membrane
E	0034220	biological_process	monoatomic ion transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue SO4 A 301

Chain	Residue
A	LYS42
B	ARG97
B	HOH429
B	HOH460
B	HOH461

---

site_id	AC2
Number of Residues	2
Details	binding site for residue SO4 A 302

Chain	Residue
A	LYS173
A	ARG207

---

site_id	AC3
Number of Residues	3
Details	binding site for residue 1PE A 303

Chain	Residue
E	VAL108
A	TRP147
A	TYR195

---

site_id	AC4
Number of Residues	5
Details	binding site for residue SO4 B 301

Chain	Residue
B	LYS42
B	HOH402
C	ARG97
C	HOH417
C	HOH438

---

site_id	AC5
Number of Residues	8
Details	binding site for residue 7LB B 302

Chain	Residue
A	ARG79
A	VAL108
A	ILE118
B	TYR93
B	TRP147
B	VAL148
B	HOH414
B	HOH441

---

site_id	AC6
Number of Residues	4
Details	binding site for residue SO4 C 301

Chain	Residue
C	LYS42
C	HOH445
D	ARG97
D	HOH428

---

site_id	AC7
Number of Residues	9
Details	binding site for residue 7LB C 302

Chain	Residue
B	VAL108
B	ILE118
B	HOH447
C	TYR93
C	SER146
C	TRP147
C	VAL148
C	TYR195
C	HOH424

---

site_id	AC8
Number of Residues	5
Details	binding site for residue SO4 D 301

Chain	Residue
D	LYS42
D	HOH423
D	HOH435
E	ARG97
E	HOH406

---

site_id	AC9
Number of Residues	7
Details	binding site for residue 7LB D 302

Chain	Residue
C	VAL108
C	ILE118
D	TYR93
D	TRP147
D	VAL148
D	TYR195
D	HOH417

---

site_id	AD1
Number of Residues	4
Details	binding site for residue SO4 E 301

Chain	Residue
A	ARG97
A	HOH419
E	LYS42
E	HOH419

---

site_id	AD2
Number of Residues	10
Details	binding site for residue 7LB E 302

Chain	Residue
D	VAL108
D	MET116
E	TYR93
E	SER146
E	TRP147
E	VAL148
E	CYS191
E	GLU193
E	TYR195
E	HOH428

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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