5TV1
active arrestin-3 with inositol hexakisphosphate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000822 | molecular_function | inositol hexakisphosphate binding |
| A | 0002029 | biological_process | desensitization of G protein-coupled receptor signaling pathway |
| A | 0002031 | biological_process | G protein-coupled receptor internalization |
| A | 0002092 | biological_process | positive regulation of receptor internalization |
| A | 0005547 | molecular_function | phosphatidylinositol-3,4,5-trisphosphate binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0005905 | cellular_component | clathrin-coated pit |
| A | 0007165 | biological_process | signal transduction |
| A | 0009968 | biological_process | negative regulation of signal transduction |
| A | 0015031 | biological_process | protein transport |
| A | 0030139 | cellular_component | endocytic vesicle |
| A | 0031410 | cellular_component | cytoplasmic vesicle |
| A | 0031623 | biological_process | receptor internalization |
| A | 0031701 | molecular_function | angiotensin receptor binding |
| A | 0035091 | molecular_function | phosphatidylinositol binding |
| A | 0060090 | molecular_function | molecular adaptor activity |
| A | 0070374 | biological_process | positive regulation of ERK1 and ERK2 cascade |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue IHP A 401 |
| Chain | Residue |
| A | ARG104 |
| A | LYS108 |
| A | THR226 |
| A | LYS227 |
| A | ARG332 |
| A | HOH501 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue IHP A 402 |
| Chain | Residue |
| A | LYS251 |
| A | LYS325 |
| A | LYS327 |
| A | GOL403 |
| A | LYS161 |
| A | LYS233 |
| A | ARG237 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue GOL A 403 |
| Chain | Residue |
| A | LYS12 |
| A | LYS295 |
| A | IHP402 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue GOL A 404 |
| Chain | Residue |
| A | GLN182 |
| A | SER184 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | binding site for residue GOL A 405 |
| Chain | Residue |
| A | PRO179 |
| A | GLY180 |
Functional Information from PROSITE/UniProt
| site_id | PS00295 |
| Number of Residues | 19 |
| Details | ARRESTINS Arrestins signature. FRYGrEDlDVLGLsFrKDL |
| Chain | Residue | Details |
| A | PHE62-LEU80 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q91YI4 |
| Chain | Residue | Details |
| A | TYR48 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: Hydroxyproline; by PHD2 => ECO:0000250 |
| Chain | Residue | Details |
| A | PRO176 | |
| A | PRO181 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P29067 |
| Chain | Residue | Details |
| A | SER360 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P29067 |
| Chain | Residue | Details |
| A | ARG393 |
