5TRM
Crystal structure of human GCN5 histone acetyltransferase domain
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004402 | molecular_function | histone acetyltransferase activity |
| A | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| B | 0004402 | molecular_function | histone acetyltransferase activity |
| B | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| C | 0004402 | molecular_function | histone acetyltransferase activity |
| C | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| D | 0004402 | molecular_function | histone acetyltransferase activity |
| D | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| E | 0004402 | molecular_function | histone acetyltransferase activity |
| E | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| F | 0004402 | molecular_function | histone acetyltransferase activity |
| F | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| G | 0004402 | molecular_function | histone acetyltransferase activity |
| G | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| H | 0004402 | molecular_function | histone acetyltransferase activity |
| H | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| I | 0004402 | molecular_function | histone acetyltransferase activity |
| I | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| J | 0004402 | molecular_function | histone acetyltransferase activity |
| J | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| K | 0004402 | molecular_function | histone acetyltransferase activity |
| K | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| L | 0004402 | molecular_function | histone acetyltransferase activity |
| L | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| M | 0004402 | molecular_function | histone acetyltransferase activity |
| M | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| N | 0004402 | molecular_function | histone acetyltransferase activity |
| N | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| O | 0004402 | molecular_function | histone acetyltransferase activity |
| O | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| P | 0004402 | molecular_function | histone acetyltransferase activity |
| P | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| Q | 0004402 | molecular_function | histone acetyltransferase activity |
| Q | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| R | 0004402 | molecular_function | histone acetyltransferase activity |
| R | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| S | 0004402 | molecular_function | histone acetyltransferase activity |
| S | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| T | 0004402 | molecular_function | histone acetyltransferase activity |
| T | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| U | 0004402 | molecular_function | histone acetyltransferase activity |
| U | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| V | 0004402 | molecular_function | histone acetyltransferase activity |
| V | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| W | 0004402 | molecular_function | histone acetyltransferase activity |
| W | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| X | 0004402 | molecular_function | histone acetyltransferase activity |
| X | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | ACT_SITE: Proton donor/acceptor => ECO:0000269|PubMed:27796307, ECO:0000269|PubMed:31527837 |
| Chain | Residue | Details |
| A | GLU575 | |
| O | GLU575 | |
| N | GLU575 | |
| M | GLU575 | |
| L | GLU575 | |
| K | GLU575 | |
| J | GLU575 | |
| F | GLU575 | |
| C | GLU575 | |
| B | GLU575 | |
| D | GLU575 | |
| W | GLU575 | |
| E | GLU575 | |
| G | GLU575 | |
| H | GLU575 | |
| I | GLU575 | |
| X | GLU575 | |
| V | GLU575 | |
| U | GLU575 | |
| T | GLU575 | |
| S | GLU575 | |
| R | GLU575 | |
| Q | GLU575 | |
| P | GLU575 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 72 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:29211711, ECO:0007744|PDB:5TRL |
| Chain | Residue | Details |
| A | CYS579 | |
| U | CYS579 | |
| U | GLN586 | |
| U | TYR617 | |
| T | CYS579 | |
| T | GLN586 | |
| T | TYR617 | |
| S | CYS579 | |
| S | GLN586 | |
| S | TYR617 | |
| R | CYS579 | |
| A | GLN586 | |
| R | GLN586 | |
| R | TYR617 | |
| Q | CYS579 | |
| Q | GLN586 | |
| Q | TYR617 | |
| P | CYS579 | |
| P | GLN586 | |
| P | TYR617 | |
| O | CYS579 | |
| O | GLN586 | |
| A | TYR617 | |
| O | TYR617 | |
| N | CYS579 | |
| N | GLN586 | |
| N | TYR617 | |
| M | CYS579 | |
| M | GLN586 | |
| M | TYR617 | |
| L | CYS579 | |
| L | GLN586 | |
| L | TYR617 | |
| W | CYS579 | |
| K | CYS579 | |
| K | GLN586 | |
| K | TYR617 | |
| J | CYS579 | |
| J | GLN586 | |
| J | TYR617 | |
| F | CYS579 | |
| F | GLN586 | |
| F | TYR617 | |
| C | CYS579 | |
| W | GLN586 | |
| C | GLN586 | |
| C | TYR617 | |
| B | CYS579 | |
| B | GLN586 | |
| B | TYR617 | |
| D | CYS579 | |
| D | GLN586 | |
| D | TYR617 | |
| E | CYS579 | |
| E | GLN586 | |
| W | TYR617 | |
| E | TYR617 | |
| G | CYS579 | |
| G | GLN586 | |
| G | TYR617 | |
| H | CYS579 | |
| H | GLN586 | |
| H | TYR617 | |
| I | CYS579 | |
| I | GLN586 | |
| I | TYR617 | |
| V | CYS579 | |
| X | CYS579 | |
| X | GLN586 | |
| X | TYR617 | |
| V | GLN586 | |
| V | TYR617 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 24 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:23142079 |
| Chain | Residue | Details |
| A | LYS549 | |
| O | LYS549 | |
| N | LYS549 | |
| M | LYS549 | |
| L | LYS549 | |
| K | LYS549 | |
| J | LYS549 | |
| F | LYS549 | |
| C | LYS549 | |
| B | LYS549 | |
| D | LYS549 | |
| W | LYS549 | |
| E | LYS549 | |
| G | LYS549 | |
| H | LYS549 | |
| I | LYS549 | |
| X | LYS549 | |
| V | LYS549 | |
| U | LYS549 | |
| T | LYS549 | |
| S | LYS549 | |
| R | LYS549 | |
| Q | LYS549 | |
| P | LYS549 |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 9 |
| Details | M-CSA 524 |
| Chain | Residue | Details |
| A | PHE568 | electrostatic stabiliser |
| A | PHE573 | electrostatic stabiliser |
| A | GLU575 | proton acceptor |
| A | ILE576 | electrostatic stabiliser |
| A | VAL577 | electrostatic stabiliser |
| A | CYS579 | electrostatic stabiliser |
| A | LEU611 | electrostatic stabiliser |
| A | ILE642 | electrostatic stabiliser |
| A | TYR645 | electrostatic stabiliser |
| site_id | MCSA10 |
| Number of Residues | 9 |
| Details | M-CSA 524 |
| Chain | Residue | Details |
| J | PHE568 | electrostatic stabiliser |
| J | PHE573 | electrostatic stabiliser |
| J | GLU575 | proton acceptor |
| J | ILE576 | electrostatic stabiliser |
| J | VAL577 | electrostatic stabiliser |
| J | CYS579 | electrostatic stabiliser |
| J | LEU611 | electrostatic stabiliser |
| J | ILE642 | electrostatic stabiliser |
| J | TYR645 | electrostatic stabiliser |
| site_id | MCSA11 |
| Number of Residues | 9 |
| Details | M-CSA 524 |
| Chain | Residue | Details |
| K | PHE568 | electrostatic stabiliser |
| K | PHE573 | electrostatic stabiliser |
| K | GLU575 | proton acceptor |
| K | ILE576 | electrostatic stabiliser |
| K | VAL577 | electrostatic stabiliser |
| K | CYS579 | electrostatic stabiliser |
| K | LEU611 | electrostatic stabiliser |
| K | ILE642 | electrostatic stabiliser |
| K | TYR645 | electrostatic stabiliser |
| site_id | MCSA12 |
| Number of Residues | 9 |
| Details | M-CSA 524 |
| Chain | Residue | Details |
| L | PHE568 | electrostatic stabiliser |
| L | PHE573 | electrostatic stabiliser |
| L | GLU575 | proton acceptor |
| L | ILE576 | electrostatic stabiliser |
| L | VAL577 | electrostatic stabiliser |
| L | CYS579 | electrostatic stabiliser |
| L | LEU611 | electrostatic stabiliser |
| L | ILE642 | electrostatic stabiliser |
| L | TYR645 | electrostatic stabiliser |
| site_id | MCSA13 |
| Number of Residues | 9 |
| Details | M-CSA 524 |
| Chain | Residue | Details |
| M | PHE568 | electrostatic stabiliser |
| M | PHE573 | electrostatic stabiliser |
| M | GLU575 | proton acceptor |
| M | ILE576 | electrostatic stabiliser |
| M | VAL577 | electrostatic stabiliser |
| M | CYS579 | electrostatic stabiliser |
| M | LEU611 | electrostatic stabiliser |
| M | ILE642 | electrostatic stabiliser |
| M | TYR645 | electrostatic stabiliser |
| site_id | MCSA14 |
| Number of Residues | 9 |
| Details | M-CSA 524 |
| Chain | Residue | Details |
| N | PHE568 | electrostatic stabiliser |
| N | PHE573 | electrostatic stabiliser |
| N | GLU575 | proton acceptor |
| N | ILE576 | electrostatic stabiliser |
| N | VAL577 | electrostatic stabiliser |
| N | CYS579 | electrostatic stabiliser |
| N | LEU611 | electrostatic stabiliser |
| N | ILE642 | electrostatic stabiliser |
| N | TYR645 | electrostatic stabiliser |
| site_id | MCSA15 |
| Number of Residues | 9 |
| Details | M-CSA 524 |
| Chain | Residue | Details |
| O | PHE568 | electrostatic stabiliser |
| O | PHE573 | electrostatic stabiliser |
| O | GLU575 | proton acceptor |
| O | ILE576 | electrostatic stabiliser |
| O | VAL577 | electrostatic stabiliser |
| O | CYS579 | electrostatic stabiliser |
| O | LEU611 | electrostatic stabiliser |
| O | ILE642 | electrostatic stabiliser |
| O | TYR645 | electrostatic stabiliser |
| site_id | MCSA16 |
| Number of Residues | 9 |
| Details | M-CSA 524 |
| Chain | Residue | Details |
| P | PHE568 | electrostatic stabiliser |
| P | PHE573 | electrostatic stabiliser |
| P | GLU575 | proton acceptor |
| P | ILE576 | electrostatic stabiliser |
| P | VAL577 | electrostatic stabiliser |
| P | CYS579 | electrostatic stabiliser |
| P | LEU611 | electrostatic stabiliser |
| P | ILE642 | electrostatic stabiliser |
| P | TYR645 | electrostatic stabiliser |
| site_id | MCSA17 |
| Number of Residues | 9 |
| Details | M-CSA 524 |
| Chain | Residue | Details |
| Q | PHE568 | electrostatic stabiliser |
| Q | PHE573 | electrostatic stabiliser |
| Q | GLU575 | proton acceptor |
| Q | ILE576 | electrostatic stabiliser |
| Q | VAL577 | electrostatic stabiliser |
| Q | CYS579 | electrostatic stabiliser |
| Q | LEU611 | electrostatic stabiliser |
| Q | ILE642 | electrostatic stabiliser |
| Q | TYR645 | electrostatic stabiliser |
| site_id | MCSA18 |
| Number of Residues | 9 |
| Details | M-CSA 524 |
| Chain | Residue | Details |
| R | PHE568 | electrostatic stabiliser |
| R | PHE573 | electrostatic stabiliser |
| R | GLU575 | proton acceptor |
| R | ILE576 | electrostatic stabiliser |
| R | VAL577 | electrostatic stabiliser |
| R | CYS579 | electrostatic stabiliser |
| R | LEU611 | electrostatic stabiliser |
| R | ILE642 | electrostatic stabiliser |
| R | TYR645 | electrostatic stabiliser |
| site_id | MCSA19 |
| Number of Residues | 9 |
| Details | M-CSA 524 |
| Chain | Residue | Details |
| S | PHE568 | electrostatic stabiliser |
| S | PHE573 | electrostatic stabiliser |
| S | GLU575 | proton acceptor |
| S | ILE576 | electrostatic stabiliser |
| S | VAL577 | electrostatic stabiliser |
| S | CYS579 | electrostatic stabiliser |
| S | LEU611 | electrostatic stabiliser |
| S | ILE642 | electrostatic stabiliser |
| S | TYR645 | electrostatic stabiliser |
| site_id | MCSA2 |
| Number of Residues | 9 |
| Details | M-CSA 524 |
| Chain | Residue | Details |
| B | PHE568 | electrostatic stabiliser |
| B | PHE573 | electrostatic stabiliser |
| B | GLU575 | proton acceptor |
| B | ILE576 | electrostatic stabiliser |
| B | VAL577 | electrostatic stabiliser |
| B | CYS579 | electrostatic stabiliser |
| B | LEU611 | electrostatic stabiliser |
| B | ILE642 | electrostatic stabiliser |
| B | TYR645 | electrostatic stabiliser |
| site_id | MCSA20 |
| Number of Residues | 9 |
| Details | M-CSA 524 |
| Chain | Residue | Details |
| T | PHE568 | electrostatic stabiliser |
| T | PHE573 | electrostatic stabiliser |
| T | GLU575 | proton acceptor |
| T | ILE576 | electrostatic stabiliser |
| T | VAL577 | electrostatic stabiliser |
| T | CYS579 | electrostatic stabiliser |
| T | LEU611 | electrostatic stabiliser |
| T | ILE642 | electrostatic stabiliser |
| T | TYR645 | electrostatic stabiliser |
| site_id | MCSA21 |
| Number of Residues | 9 |
| Details | M-CSA 524 |
| Chain | Residue | Details |
| U | PHE568 | electrostatic stabiliser |
| U | PHE573 | electrostatic stabiliser |
| U | GLU575 | proton acceptor |
| U | ILE576 | electrostatic stabiliser |
| U | VAL577 | electrostatic stabiliser |
| U | CYS579 | electrostatic stabiliser |
| U | LEU611 | electrostatic stabiliser |
| U | ILE642 | electrostatic stabiliser |
| U | TYR645 | electrostatic stabiliser |
| site_id | MCSA22 |
| Number of Residues | 9 |
| Details | M-CSA 524 |
| Chain | Residue | Details |
| V | PHE568 | electrostatic stabiliser |
| V | PHE573 | electrostatic stabiliser |
| V | GLU575 | proton acceptor |
| V | ILE576 | electrostatic stabiliser |
| V | VAL577 | electrostatic stabiliser |
| V | CYS579 | electrostatic stabiliser |
| V | LEU611 | electrostatic stabiliser |
| V | ILE642 | electrostatic stabiliser |
| V | TYR645 | electrostatic stabiliser |
| site_id | MCSA23 |
| Number of Residues | 9 |
| Details | M-CSA 524 |
| Chain | Residue | Details |
| W | PHE568 | electrostatic stabiliser |
| W | PHE573 | electrostatic stabiliser |
| W | GLU575 | proton acceptor |
| W | ILE576 | electrostatic stabiliser |
| W | VAL577 | electrostatic stabiliser |
| W | CYS579 | electrostatic stabiliser |
| W | LEU611 | electrostatic stabiliser |
| W | ILE642 | electrostatic stabiliser |
| W | TYR645 | electrostatic stabiliser |
| site_id | MCSA24 |
| Number of Residues | 9 |
| Details | M-CSA 524 |
| Chain | Residue | Details |
| X | PHE568 | electrostatic stabiliser |
| X | PHE573 | electrostatic stabiliser |
| X | GLU575 | proton acceptor |
| X | ILE576 | electrostatic stabiliser |
| X | VAL577 | electrostatic stabiliser |
| X | CYS579 | electrostatic stabiliser |
| X | LEU611 | electrostatic stabiliser |
| X | ILE642 | electrostatic stabiliser |
| X | TYR645 | electrostatic stabiliser |
| site_id | MCSA3 |
| Number of Residues | 9 |
| Details | M-CSA 524 |
| Chain | Residue | Details |
| C | PHE568 | electrostatic stabiliser |
| C | PHE573 | electrostatic stabiliser |
| C | GLU575 | proton acceptor |
| C | ILE576 | electrostatic stabiliser |
| C | VAL577 | electrostatic stabiliser |
| C | CYS579 | electrostatic stabiliser |
| C | LEU611 | electrostatic stabiliser |
| C | ILE642 | electrostatic stabiliser |
| C | TYR645 | electrostatic stabiliser |
| site_id | MCSA4 |
| Number of Residues | 9 |
| Details | M-CSA 524 |
| Chain | Residue | Details |
| D | PHE568 | electrostatic stabiliser |
| D | PHE573 | electrostatic stabiliser |
| D | GLU575 | proton acceptor |
| D | ILE576 | electrostatic stabiliser |
| D | VAL577 | electrostatic stabiliser |
| D | CYS579 | electrostatic stabiliser |
| D | LEU611 | electrostatic stabiliser |
| D | ILE642 | electrostatic stabiliser |
| D | TYR645 | electrostatic stabiliser |
| site_id | MCSA5 |
| Number of Residues | 9 |
| Details | M-CSA 524 |
| Chain | Residue | Details |
| E | PHE568 | electrostatic stabiliser |
| E | PHE573 | electrostatic stabiliser |
| E | GLU575 | proton acceptor |
| E | ILE576 | electrostatic stabiliser |
| E | VAL577 | electrostatic stabiliser |
| E | CYS579 | electrostatic stabiliser |
| E | LEU611 | electrostatic stabiliser |
| E | ILE642 | electrostatic stabiliser |
| E | TYR645 | electrostatic stabiliser |
| site_id | MCSA6 |
| Number of Residues | 9 |
| Details | M-CSA 524 |
| Chain | Residue | Details |
| F | PHE568 | electrostatic stabiliser |
| F | PHE573 | electrostatic stabiliser |
| F | GLU575 | proton acceptor |
| F | ILE576 | electrostatic stabiliser |
| F | VAL577 | electrostatic stabiliser |
| F | CYS579 | electrostatic stabiliser |
| F | LEU611 | electrostatic stabiliser |
| F | ILE642 | electrostatic stabiliser |
| F | TYR645 | electrostatic stabiliser |
| site_id | MCSA7 |
| Number of Residues | 9 |
| Details | M-CSA 524 |
| Chain | Residue | Details |
| G | PHE568 | electrostatic stabiliser |
| G | PHE573 | electrostatic stabiliser |
| G | GLU575 | proton acceptor |
| G | ILE576 | electrostatic stabiliser |
| G | VAL577 | electrostatic stabiliser |
| G | CYS579 | electrostatic stabiliser |
| G | LEU611 | electrostatic stabiliser |
| G | ILE642 | electrostatic stabiliser |
| G | TYR645 | electrostatic stabiliser |
| site_id | MCSA8 |
| Number of Residues | 9 |
| Details | M-CSA 524 |
| Chain | Residue | Details |
| H | PHE568 | electrostatic stabiliser |
| H | PHE573 | electrostatic stabiliser |
| H | GLU575 | proton acceptor |
| H | ILE576 | electrostatic stabiliser |
| H | VAL577 | electrostatic stabiliser |
| H | CYS579 | electrostatic stabiliser |
| H | LEU611 | electrostatic stabiliser |
| H | ILE642 | electrostatic stabiliser |
| H | TYR645 | electrostatic stabiliser |
| site_id | MCSA9 |
| Number of Residues | 9 |
| Details | M-CSA 524 |
| Chain | Residue | Details |
| I | PHE568 | electrostatic stabiliser |
| I | PHE573 | electrostatic stabiliser |
| I | GLU575 | proton acceptor |
| I | ILE576 | electrostatic stabiliser |
| I | VAL577 | electrostatic stabiliser |
| I | CYS579 | electrostatic stabiliser |
| I | LEU611 | electrostatic stabiliser |
| I | ILE642 | electrostatic stabiliser |
| I | TYR645 | electrostatic stabiliser |
