5TRE

Zinc and the Iron Donor Frataxin Regulate Oligomerization of the Scaffold Protein to Form New Fe-S Cluster Assembly Centers

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004322	molecular_function	ferroxidase activity
A	0005739	cellular_component	mitochondrion
A	0006879	biological_process	intracellular iron ion homeostasis
A	0008199	molecular_function	ferric iron binding
A	0016226	biological_process	iron-sulfur cluster assembly
A	0018283	biological_process	iron incorporation into metallo-sulfur cluster
B	0004322	molecular_function	ferroxidase activity
B	0005739	cellular_component	mitochondrion
B	0006879	biological_process	intracellular iron ion homeostasis
B	0008199	molecular_function	ferric iron binding
B	0016226	biological_process	iron-sulfur cluster assembly
B	0018283	biological_process	iron incorporation into metallo-sulfur cluster
C	0004322	molecular_function	ferroxidase activity
C	0005739	cellular_component	mitochondrion
C	0006879	biological_process	intracellular iron ion homeostasis
C	0008199	molecular_function	ferric iron binding
C	0016226	biological_process	iron-sulfur cluster assembly
C	0018283	biological_process	iron incorporation into metallo-sulfur cluster
D	0004322	molecular_function	ferroxidase activity
D	0005739	cellular_component	mitochondrion
D	0006879	biological_process	intracellular iron ion homeostasis
D	0008199	molecular_function	ferric iron binding
D	0016226	biological_process	iron-sulfur cluster assembly
D	0018283	biological_process	iron incorporation into metallo-sulfur cluster
E	0004322	molecular_function	ferroxidase activity
E	0005739	cellular_component	mitochondrion
E	0006879	biological_process	intracellular iron ion homeostasis
E	0008199	molecular_function	ferric iron binding
E	0016226	biological_process	iron-sulfur cluster assembly
E	0018283	biological_process	iron incorporation into metallo-sulfur cluster
F	0004322	molecular_function	ferroxidase activity
F	0005739	cellular_component	mitochondrion
F	0006879	biological_process	intracellular iron ion homeostasis
F	0008199	molecular_function	ferric iron binding
F	0016226	biological_process	iron-sulfur cluster assembly
F	0018283	biological_process	iron incorporation into metallo-sulfur cluster
G	0004322	molecular_function	ferroxidase activity
G	0005739	cellular_component	mitochondrion
G	0006879	biological_process	intracellular iron ion homeostasis
G	0008199	molecular_function	ferric iron binding
G	0016226	biological_process	iron-sulfur cluster assembly
G	0018283	biological_process	iron incorporation into metallo-sulfur cluster
H	0004322	molecular_function	ferroxidase activity
H	0005739	cellular_component	mitochondrion
H	0006879	biological_process	intracellular iron ion homeostasis
H	0008199	molecular_function	ferric iron binding
H	0016226	biological_process	iron-sulfur cluster assembly
H	0018283	biological_process	iron incorporation into metallo-sulfur cluster
I	0004322	molecular_function	ferroxidase activity
I	0005739	cellular_component	mitochondrion
I	0006879	biological_process	intracellular iron ion homeostasis
I	0008199	molecular_function	ferric iron binding
I	0016226	biological_process	iron-sulfur cluster assembly
I	0018283	biological_process	iron incorporation into metallo-sulfur cluster
J	0004322	molecular_function	ferroxidase activity
J	0005739	cellular_component	mitochondrion
J	0006879	biological_process	intracellular iron ion homeostasis
J	0008199	molecular_function	ferric iron binding
J	0016226	biological_process	iron-sulfur cluster assembly
J	0018283	biological_process	iron incorporation into metallo-sulfur cluster
K	0004322	molecular_function	ferroxidase activity
K	0005739	cellular_component	mitochondrion
K	0006879	biological_process	intracellular iron ion homeostasis
K	0008199	molecular_function	ferric iron binding
K	0016226	biological_process	iron-sulfur cluster assembly
K	0018283	biological_process	iron incorporation into metallo-sulfur cluster
L	0004322	molecular_function	ferroxidase activity
L	0005739	cellular_component	mitochondrion
L	0006879	biological_process	intracellular iron ion homeostasis
L	0008199	molecular_function	ferric iron binding
L	0016226	biological_process	iron-sulfur cluster assembly
L	0018283	biological_process	iron incorporation into metallo-sulfur cluster
M	0004322	molecular_function	ferroxidase activity
M	0005739	cellular_component	mitochondrion
M	0006879	biological_process	intracellular iron ion homeostasis
M	0008199	molecular_function	ferric iron binding
M	0016226	biological_process	iron-sulfur cluster assembly
M	0018283	biological_process	iron incorporation into metallo-sulfur cluster
N	0004322	molecular_function	ferroxidase activity
N	0005739	cellular_component	mitochondrion
N	0006879	biological_process	intracellular iron ion homeostasis
N	0008199	molecular_function	ferric iron binding
N	0016226	biological_process	iron-sulfur cluster assembly
N	0018283	biological_process	iron incorporation into metallo-sulfur cluster
O	0004322	molecular_function	ferroxidase activity
O	0005739	cellular_component	mitochondrion
O	0006879	biological_process	intracellular iron ion homeostasis
O	0008199	molecular_function	ferric iron binding
O	0016226	biological_process	iron-sulfur cluster assembly
O	0018283	biological_process	iron incorporation into metallo-sulfur cluster
P	0004322	molecular_function	ferroxidase activity
P	0005739	cellular_component	mitochondrion
P	0006879	biological_process	intracellular iron ion homeostasis
P	0008199	molecular_function	ferric iron binding
P	0016226	biological_process	iron-sulfur cluster assembly
P	0018283	biological_process	iron incorporation into metallo-sulfur cluster
Q	0004322	molecular_function	ferroxidase activity
Q	0005739	cellular_component	mitochondrion
Q	0006879	biological_process	intracellular iron ion homeostasis
Q	0008199	molecular_function	ferric iron binding
Q	0016226	biological_process	iron-sulfur cluster assembly
Q	0018283	biological_process	iron incorporation into metallo-sulfur cluster
R	0004322	molecular_function	ferroxidase activity
R	0005739	cellular_component	mitochondrion
R	0006879	biological_process	intracellular iron ion homeostasis
R	0008199	molecular_function	ferric iron binding
R	0016226	biological_process	iron-sulfur cluster assembly
R	0018283	biological_process	iron incorporation into metallo-sulfur cluster
S	0004322	molecular_function	ferroxidase activity
S	0005739	cellular_component	mitochondrion
S	0006879	biological_process	intracellular iron ion homeostasis
S	0008199	molecular_function	ferric iron binding
S	0016226	biological_process	iron-sulfur cluster assembly
S	0018283	biological_process	iron incorporation into metallo-sulfur cluster
T	0004322	molecular_function	ferroxidase activity
T	0005739	cellular_component	mitochondrion
T	0006879	biological_process	intracellular iron ion homeostasis
T	0008199	molecular_function	ferric iron binding
T	0016226	biological_process	iron-sulfur cluster assembly
T	0018283	biological_process	iron incorporation into metallo-sulfur cluster
U	0004322	molecular_function	ferroxidase activity
U	0005739	cellular_component	mitochondrion
U	0006879	biological_process	intracellular iron ion homeostasis
U	0008199	molecular_function	ferric iron binding
U	0016226	biological_process	iron-sulfur cluster assembly
U	0018283	biological_process	iron incorporation into metallo-sulfur cluster
V	0004322	molecular_function	ferroxidase activity
V	0005739	cellular_component	mitochondrion
V	0006879	biological_process	intracellular iron ion homeostasis
V	0008199	molecular_function	ferric iron binding
V	0016226	biological_process	iron-sulfur cluster assembly
V	0018283	biological_process	iron incorporation into metallo-sulfur cluster
W	0004322	molecular_function	ferroxidase activity
W	0005739	cellular_component	mitochondrion
W	0006879	biological_process	intracellular iron ion homeostasis
W	0008199	molecular_function	ferric iron binding
W	0016226	biological_process	iron-sulfur cluster assembly
W	0018283	biological_process	iron incorporation into metallo-sulfur cluster
X	0004322	molecular_function	ferroxidase activity
X	0005739	cellular_component	mitochondrion
X	0006879	biological_process	intracellular iron ion homeostasis
X	0008199	molecular_function	ferric iron binding
X	0016226	biological_process	iron-sulfur cluster assembly
X	0018283	biological_process	iron incorporation into metallo-sulfur cluster
a	0005506	molecular_function	iron ion binding
a	0016226	biological_process	iron-sulfur cluster assembly
a	0051536	molecular_function	iron-sulfur cluster binding
b	0005506	molecular_function	iron ion binding
b	0016226	biological_process	iron-sulfur cluster assembly
b	0051536	molecular_function	iron-sulfur cluster binding
c	0005506	molecular_function	iron ion binding
c	0016226	biological_process	iron-sulfur cluster assembly
c	0051536	molecular_function	iron-sulfur cluster binding
d	0005506	molecular_function	iron ion binding
d	0016226	biological_process	iron-sulfur cluster assembly
d	0051536	molecular_function	iron-sulfur cluster binding
e	0005506	molecular_function	iron ion binding
e	0016226	biological_process	iron-sulfur cluster assembly
e	0051536	molecular_function	iron-sulfur cluster binding
f	0005506	molecular_function	iron ion binding
f	0016226	biological_process	iron-sulfur cluster assembly
f	0051536	molecular_function	iron-sulfur cluster binding
g	0005506	molecular_function	iron ion binding
g	0016226	biological_process	iron-sulfur cluster assembly
g	0051536	molecular_function	iron-sulfur cluster binding
h	0005506	molecular_function	iron ion binding
h	0016226	biological_process	iron-sulfur cluster assembly
h	0051536	molecular_function	iron-sulfur cluster binding
i	0005506	molecular_function	iron ion binding
i	0016226	biological_process	iron-sulfur cluster assembly
i	0051536	molecular_function	iron-sulfur cluster binding
j	0005506	molecular_function	iron ion binding
j	0016226	biological_process	iron-sulfur cluster assembly
j	0051536	molecular_function	iron-sulfur cluster binding
k	0005506	molecular_function	iron ion binding
k	0016226	biological_process	iron-sulfur cluster assembly
k	0051536	molecular_function	iron-sulfur cluster binding
l	0005506	molecular_function	iron ion binding
l	0016226	biological_process	iron-sulfur cluster assembly
l	0051536	molecular_function	iron-sulfur cluster binding
m	0005506	molecular_function	iron ion binding
m	0016226	biological_process	iron-sulfur cluster assembly
m	0051536	molecular_function	iron-sulfur cluster binding
n	0005506	molecular_function	iron ion binding
n	0016226	biological_process	iron-sulfur cluster assembly
n	0051536	molecular_function	iron-sulfur cluster binding
o	0005506	molecular_function	iron ion binding
o	0016226	biological_process	iron-sulfur cluster assembly
o	0051536	molecular_function	iron-sulfur cluster binding
p	0005506	molecular_function	iron ion binding
p	0016226	biological_process	iron-sulfur cluster assembly
p	0051536	molecular_function	iron-sulfur cluster binding
q	0005506	molecular_function	iron ion binding
q	0016226	biological_process	iron-sulfur cluster assembly
q	0051536	molecular_function	iron-sulfur cluster binding
r	0005506	molecular_function	iron ion binding
r	0016226	biological_process	iron-sulfur cluster assembly
r	0051536	molecular_function	iron-sulfur cluster binding
s	0005506	molecular_function	iron ion binding
s	0016226	biological_process	iron-sulfur cluster assembly
s	0051536	molecular_function	iron-sulfur cluster binding
t	0005506	molecular_function	iron ion binding
t	0016226	biological_process	iron-sulfur cluster assembly
t	0051536	molecular_function	iron-sulfur cluster binding
u	0005506	molecular_function	iron ion binding
u	0016226	biological_process	iron-sulfur cluster assembly
u	0051536	molecular_function	iron-sulfur cluster binding
v	0005506	molecular_function	iron ion binding
v	0016226	biological_process	iron-sulfur cluster assembly
v	0051536	molecular_function	iron-sulfur cluster binding
w	0005506	molecular_function	iron ion binding
w	0016226	biological_process	iron-sulfur cluster assembly
w	0051536	molecular_function	iron-sulfur cluster binding
x	0005506	molecular_function	iron ion binding
x	0016226	biological_process	iron-sulfur cluster assembly
x	0051536	molecular_function	iron-sulfur cluster binding

Functional Information from PROSITE/UniProt

site_id	PS01344
Number of Residues	15
Details	FRATAXIN_1 Frataxin family signature. VINKQpPnkQIWlAS

Chain	Residue	Details
A	VAL120-SER134

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	96
Details	Region: {"description":"SSQ1 binding region","evidences":[{"source":"PubMed","id":"15123690","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---