5TNQ
Crystal structure of the E153Q mutant of the CFTR inhibitory factor Cif containing the adducted (R)-Styrene oxide hydrolysis intermediate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004301 | molecular_function | epoxide hydrolase activity |
| A | 0005576 | cellular_component | extracellular region |
| A | 0043657 | cellular_component | host cell |
| B | 0004301 | molecular_function | epoxide hydrolase activity |
| B | 0005576 | cellular_component | extracellular region |
| B | 0043657 | cellular_component | host cell |
| C | 0004301 | molecular_function | epoxide hydrolase activity |
| C | 0005576 | cellular_component | extracellular region |
| C | 0043657 | cellular_component | host cell |
| D | 0004301 | molecular_function | epoxide hydrolase activity |
| D | 0005576 | cellular_component | extracellular region |
| D | 0043657 | cellular_component | host cell |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue FEH C 401 |
| Chain | Residue |
| C | ASP129 |
| C | HIS177 |
| C | PHE178 |
| C | HIS207 |
| C | TYR239 |
| C | HIS297 |
| site_id | AC2 |
| Number of Residues | 16 |
| Details | binding site for Di-peptide FEH A 401 and ASP A 129 |
| Chain | Residue |
| A | ILE130 |
| A | GLY131 |
| A | ILE132 |
| A | MET152 |
| A | GLN153 |
| A | ALA154 |
| A | HIS177 |
| A | PHE178 |
| A | TYR239 |
| A | MET272 |
| A | HIS297 |
| A | HOH512 |
| A | HOH652 |
| A | GLY62 |
| A | PHE63 |
| A | HIS128 |
| site_id | AC3 |
| Number of Residues | 15 |
| Details | binding site for Di-peptide FEH B 401 and ASP B 129 |
| Chain | Residue |
| B | GLY62 |
| B | PHE63 |
| B | HIS128 |
| B | ILE130 |
| B | GLY131 |
| B | ILE132 |
| B | MET152 |
| B | GLN153 |
| B | ALA154 |
| B | HIS177 |
| B | PHE178 |
| B | HIS207 |
| B | TYR239 |
| B | HIS297 |
| B | HOH645 |
| site_id | AC4 |
| Number of Residues | 14 |
| Details | binding site for Di-peptide FEH D 401 and ASP D 129 |
| Chain | Residue |
| D | GLY62 |
| D | PHE63 |
| D | HIS128 |
| D | ILE130 |
| D | GLY131 |
| D | ILE132 |
| D | MET152 |
| D | GLN153 |
| D | ALA154 |
| D | HIS177 |
| D | PHE178 |
| D | TYR239 |
| D | HIS297 |
| D | HOH663 |
