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5TLR

Solution NMR structure of gHwTx-IV

Functional Information from GO Data
ChainGOidnamespacecontents
A0005576cellular_componentextracellular region
A0008200molecular_functionion channel inhibitor activity
Functional Information from PROSITE/UniProt
site_idPS60021
Number of Residues30
DetailsHWTX_1 Huwentoxin-1 family signature. CLgIwkaCnpsndqCCkssklvCsrktRWC
ChainResidueDetails
ACYS2-CYS31

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues5
DetailsSITE: Binds to the extracellular loop of voltage sensor domain II of sodium channels (Nav1.2/SCN2A and Nav1.7/SCN9A) => ECO:0000305|PubMed:23760503
ChainResidueDetails
ATRP6
AARG26
ALYS27
ATRP30
ALYS32

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Isoleucine amide => ECO:0000269|PubMed:12228241
ChainResidueDetails
AILE35

223532

PDB entries from 2024-08-07

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