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5TLI

THERMOLYSIN (60% ISOPROPANOL SOAKED CRYSTALS)

Functional Information from GO Data
ChainGOidnamespacecontents
A0004222molecular_functionmetalloendopeptidase activity
A0006508biological_processproteolysis
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE ZN A 317
ChainResidue
AHIS142
AGLU143
AHIS146
AGLU166
AHOH1002

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA A 318
ChainResidue
AGLU190
AHOH1014
AASP138
AGLU177
AASP185
AGLU187

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA A 319
ChainResidue
AGLU177
AASN183
AASP185
AGLU190
AHOH1013
AHOH1030

site_idAC4
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA A 320
ChainResidue
AASP57
AASP59
AGLN61
AHOH1016
AHOH1027
AHOH1047

site_idAC5
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA A 321
ChainResidue
ATYR193
ATHR194
AILE197
AASP200
AHOH1038
AHOH1065

site_idAC6
Number of Residues3
DetailsBINDING SITE FOR RESIDUE DMS A 2001
ChainResidue
AHIS216
ASER218
ATYR251

site_idAC7
Number of Residues4
DetailsBINDING SITE FOR RESIDUE IPA A 2002
ChainResidue
AGLU143
ALEU202
AARG203
AHOH1067

site_idAC8
Number of Residues5
DetailsBINDING SITE FOR RESIDUE IPA A 2003
ChainResidue
ATYR84
ASER92
ATYR93
AVAL148
AHOH1021

Functional Information from PROSITE/UniProt
site_idPS00142
Number of Residues10
DetailsZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VVAHELTHAV
ChainResidueDetails
AVAL139-VAL148

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsBINDING:
ChainResidueDetails
AVAL289
ASER291
ATHR293

Catalytic Information from CSA
site_idMCSA1
Number of Residues
DetailsM-CSA 176
ChainResidueDetails

site_idCSA1
Number of Residues2
DetailsAnnotated By Reference To The Literature 1tlp
ChainResidueDetails
AHIS231
AGLU143

219140

PDB entries from 2024-05-01

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